Non-Invasive Monitoring of Increased Fibrotic Tissue and Hyaluronan Deposition in the Tumor Microenvironment in the Advanced Stages of Pancreatic Ductal Adenocarcinoma

Non-Invasive Monitoring of Increased Fibrotic Tissue and Hyaluronan Deposition in the Tumor Microenvironment in the Advanced Stages of Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinomas are characterized by a complex and robust tumor microenvironment (TME) consisting of fibrotic tissue, excessive levels of hyaluronan (HA), and immune cells. We utilized quantitative multi-parametric magnetic resonance imaging (mp-MRI) methods at 14 Tesla in a geneti...

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Bibliographic Details
Main Authors: Ravneet Vohra, Yak-Nam Wang, Helena Son, Stephanie Totten, Akshit Arora, Adam Maxwell, Donghoon Lee
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma (PDAC)
multi-parametric magnetic resonance imaging (mp-MRI)
apparent diffusion coefficient (ADC)
amide proton transfer (APT)
chemical exchange saturation transfer (CEST)
glycosaminoglycan (Gag)
Online Access:https://www.mdpi.com/2072-6694/14/4/999

Internet

https://www.mdpi.com/2072-6694/14/4/999

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