Identification of immune cells infiltrating in hippocampus and key genes associated with Alzheimer’s disease
Abstract Alzheimer’s disease (AD) is the most prevalent cause of dementia and is primarily associated with memory impairment and cognitive decline, but the etiology of AD has not been elucidated. In recent years, evidence has shown that immune cells play critical roles in AD pathology. In the curren...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Medical Genomics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12920-023-01458-2 |
| _version_ | 1827982386292326400 |
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| author | Chenming Liu Sutong Xu Qiulu Liu Huazhen Chai Yuping Luo Siguang Li |
| author_facet | Chenming Liu Sutong Xu Qiulu Liu Huazhen Chai Yuping Luo Siguang Li |
| author_sort | Chenming Liu |
| collection | DOAJ |
| description | Abstract Alzheimer’s disease (AD) is the most prevalent cause of dementia and is primarily associated with memory impairment and cognitive decline, but the etiology of AD has not been elucidated. In recent years, evidence has shown that immune cells play critical roles in AD pathology. In the current study, we collected the transcriptomic data of the hippocampus from gene expression omnibus database, and investigated the effect of immune cell infiltration in the hippocampus on AD, and analyzed the key genes that influence the pathogenesis of AD patients. The results revealed that the relative abundance of immune cells in the hippocampus of AD patients was altered. Of all given 28 kinds of immune cells, monocytes were the important immune cell associated with AD. We identified 4 key genes associated with both AD and monocytes, including KDELR1, SPTAN1, CDC16 and RBBP6, and they differentially expressed in 5XFAD mice and WT mice. The logistic regression and random forest models based on the 4 key genes could effectively distinguish AD from healthy samples. Our research provided a new perspective on immunotherapy for AD patients. |
| first_indexed | 2024-04-09T22:32:31Z |
| format | Article |
| id | doaj.art-2086e57b12d84c5caac32267f5694b42 |
| institution | Directory Open Access Journal |
| issn | 1755-8794 |
| language | English |
| last_indexed | 2024-04-09T22:32:31Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genomics |
| spelling | doaj.art-2086e57b12d84c5caac32267f5694b422023-03-22T12:38:08ZengBMCBMC Medical Genomics1755-87942023-03-0116111410.1186/s12920-023-01458-2Identification of immune cells infiltrating in hippocampus and key genes associated with Alzheimer’s diseaseChenming Liu0Sutong Xu1Qiulu Liu2Huazhen Chai3Yuping Luo4Siguang Li5Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, Tongji University School of MedicineKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, Tongji University School of MedicineKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, Tongji University School of MedicineKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, Tongji University School of MedicineKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, Tongji University School of MedicineKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, Tongji University School of MedicineAbstract Alzheimer’s disease (AD) is the most prevalent cause of dementia and is primarily associated with memory impairment and cognitive decline, but the etiology of AD has not been elucidated. In recent years, evidence has shown that immune cells play critical roles in AD pathology. In the current study, we collected the transcriptomic data of the hippocampus from gene expression omnibus database, and investigated the effect of immune cell infiltration in the hippocampus on AD, and analyzed the key genes that influence the pathogenesis of AD patients. The results revealed that the relative abundance of immune cells in the hippocampus of AD patients was altered. Of all given 28 kinds of immune cells, monocytes were the important immune cell associated with AD. We identified 4 key genes associated with both AD and monocytes, including KDELR1, SPTAN1, CDC16 and RBBP6, and they differentially expressed in 5XFAD mice and WT mice. The logistic regression and random forest models based on the 4 key genes could effectively distinguish AD from healthy samples. Our research provided a new perspective on immunotherapy for AD patients.https://doi.org/10.1186/s12920-023-01458-2Alzheimer’s diseasehippocampusImmune infiltrationKey genes |
| spellingShingle | Chenming Liu Sutong Xu Qiulu Liu Huazhen Chai Yuping Luo Siguang Li Identification of immune cells infiltrating in hippocampus and key genes associated with Alzheimer’s disease BMC Medical Genomics Alzheimer’s disease hippocampus Immune infiltration Key genes |
| title | Identification of immune cells infiltrating in hippocampus and key genes associated with Alzheimer’s disease |
| title_full | Identification of immune cells infiltrating in hippocampus and key genes associated with Alzheimer’s disease |
| title_fullStr | Identification of immune cells infiltrating in hippocampus and key genes associated with Alzheimer’s disease |
| title_full_unstemmed | Identification of immune cells infiltrating in hippocampus and key genes associated with Alzheimer’s disease |
| title_short | Identification of immune cells infiltrating in hippocampus and key genes associated with Alzheimer’s disease |
| title_sort | identification of immune cells infiltrating in hippocampus and key genes associated with alzheimer s disease |
| topic | Alzheimer’s disease hippocampus Immune infiltration Key genes |
| url | https://doi.org/10.1186/s12920-023-01458-2 |
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