Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'.
Withania somnifera extracts are known for their anti-cancerous, anti-inflammatory and antioxidative properties. One of their mechanisms of actions is to modulate mitochondrial function through increasing oxidative stress. Recently 'priming' has been suggested as a potential mechanism for e...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5271386?pdf=render |
| _version_ | 1818543303653588992 |
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| author | Aine Brigette Henley Ling Yang Kun-Lin Chuang Meliz Sahuri-Arisoylu Li-Hong Wu S W Annie Bligh Jimmy David Bell |
| author_facet | Aine Brigette Henley Ling Yang Kun-Lin Chuang Meliz Sahuri-Arisoylu Li-Hong Wu S W Annie Bligh Jimmy David Bell |
| author_sort | Aine Brigette Henley |
| collection | DOAJ |
| description | Withania somnifera extracts are known for their anti-cancerous, anti-inflammatory and antioxidative properties. One of their mechanisms of actions is to modulate mitochondrial function through increasing oxidative stress. Recently 'priming' has been suggested as a potential mechanism for enhancing cancer cell death. In this study we demonstrate that 'priming', in HT-29 colon cells, with W. somnifera root extract increased the potency of the chemotherapeutic agent cisplatin. We have also showed the W. somnifera root extract enhanced mitochondrial dysfunction and that the underlying mechanism of 'priming' was selectively through increased ROS. Moreover, we showed that this effect was not seen in non-cancerous cells. |
| first_indexed | 2024-12-11T22:33:36Z |
| format | Article |
| id | doaj.art-2086f43e11c04c4aa63d419e63f9247b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T22:33:36Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2086f43e11c04c4aa63d419e63f9247b2022-12-22T00:48:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01121e017091710.1371/journal.pone.0170917Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'.Aine Brigette HenleyLing YangKun-Lin ChuangMeliz Sahuri-ArisoyluLi-Hong WuS W Annie BlighJimmy David BellWithania somnifera extracts are known for their anti-cancerous, anti-inflammatory and antioxidative properties. One of their mechanisms of actions is to modulate mitochondrial function through increasing oxidative stress. Recently 'priming' has been suggested as a potential mechanism for enhancing cancer cell death. In this study we demonstrate that 'priming', in HT-29 colon cells, with W. somnifera root extract increased the potency of the chemotherapeutic agent cisplatin. We have also showed the W. somnifera root extract enhanced mitochondrial dysfunction and that the underlying mechanism of 'priming' was selectively through increased ROS. Moreover, we showed that this effect was not seen in non-cancerous cells.http://europepmc.org/articles/PMC5271386?pdf=render |
| spellingShingle | Aine Brigette Henley Ling Yang Kun-Lin Chuang Meliz Sahuri-Arisoylu Li-Hong Wu S W Annie Bligh Jimmy David Bell Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'. PLoS ONE |
| title | Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'. |
| title_full | Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'. |
| title_fullStr | Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'. |
| title_full_unstemmed | Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'. |
| title_short | Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'. |
| title_sort | withania somnifera root extract enhances chemotherapy through priming |
| url | http://europepmc.org/articles/PMC5271386?pdf=render |
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