A multifunctional integrated biomimetic spore nanoplatform for successively overcoming oral biological barriers
Abstract The biological barriers have seriously restricted the efficacious responses of oral delivery system in diseases treatment. Utilizing a carrier based on the single construction means is hard to overcome these obstacles simultaneously because the complex gastrointestinal tract environment req...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-08-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-023-01995-z |
| _version_ | 1827708507665727488 |
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| author | Qingling Song Junfei Yang Xiaocui Wu Yao Li Hongjuan Zhao Qianhua Feng Zhenzhong Zhang Yun Zhang Lei Wang |
| author_facet | Qingling Song Junfei Yang Xiaocui Wu Yao Li Hongjuan Zhao Qianhua Feng Zhenzhong Zhang Yun Zhang Lei Wang |
| author_sort | Qingling Song |
| collection | DOAJ |
| description | Abstract The biological barriers have seriously restricted the efficacious responses of oral delivery system in diseases treatment. Utilizing a carrier based on the single construction means is hard to overcome these obstacles simultaneously because the complex gastrointestinal tract environment requires carrier to have different or even contradictory properties. Interestingly, spore capsid (SC) integrates many unique biological characteristics, such as high resistance, good stability etc. This fact offers a boundless source of inspiration for the construction of multi-functional oral nanoplatform based on SC without further modification. Herein, we develop a type of biomimetic spore nanoplatform (SC@DS NPs) to successively overcome oral biological barriers. Firstly, doxorubicin (DOX) and sorafenib (SOR) are self-assembled to form carrier-free nanoparticles (DS NPs). Subsequently, SC is effectively separated from probiotic spores and served as a functional vehicle for delivering DS NPs. As expect, SC@DS NPs can efficaciously pass through the rugged stomach environment after oral administration and further be transported to the intestine. Surprisingly, we find that SC@DS NPs exhibit a significant improvement in the aspects of mucus penetration and transepithelial transport, which is related to the protein species of SC. This study demonstrates that SC@DS NPs can efficiently overcome multiple biological barriers and improve the therapeutic effect. |
| first_indexed | 2024-03-10T17:06:35Z |
| format | Article |
| id | doaj.art-208aeb94ed3b4448b9deeb288f387037 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-03-10T17:06:35Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-208aeb94ed3b4448b9deeb288f3870372023-11-20T10:48:06ZengBMCJournal of Nanobiotechnology1477-31552023-08-0121111210.1186/s12951-023-01995-zA multifunctional integrated biomimetic spore nanoplatform for successively overcoming oral biological barriersQingling Song0Junfei Yang1Xiaocui Wu2Yao Li3Hongjuan Zhao4Qianhua Feng5Zhenzhong Zhang6Yun Zhang7Lei Wang8School of Pharmaceutical Sciences, Zhengzhou UniversitySchool of Pharmaceutical Sciences, Zhengzhou UniversitySchool of Pharmaceutical Sciences, Zhengzhou UniversitySchool of Pharmaceutical Sciences, Zhengzhou UniversitySchool of Pharmaceutical Sciences, Zhengzhou UniversitySchool of Pharmaceutical Sciences, Zhengzhou UniversitySchool of Pharmaceutical Sciences, Zhengzhou UniversitySchool of Pharmaceutical Sciences, Zhengzhou UniversitySchool of Pharmaceutical Sciences, Zhengzhou UniversityAbstract The biological barriers have seriously restricted the efficacious responses of oral delivery system in diseases treatment. Utilizing a carrier based on the single construction means is hard to overcome these obstacles simultaneously because the complex gastrointestinal tract environment requires carrier to have different or even contradictory properties. Interestingly, spore capsid (SC) integrates many unique biological characteristics, such as high resistance, good stability etc. This fact offers a boundless source of inspiration for the construction of multi-functional oral nanoplatform based on SC without further modification. Herein, we develop a type of biomimetic spore nanoplatform (SC@DS NPs) to successively overcome oral biological barriers. Firstly, doxorubicin (DOX) and sorafenib (SOR) are self-assembled to form carrier-free nanoparticles (DS NPs). Subsequently, SC is effectively separated from probiotic spores and served as a functional vehicle for delivering DS NPs. As expect, SC@DS NPs can efficaciously pass through the rugged stomach environment after oral administration and further be transported to the intestine. Surprisingly, we find that SC@DS NPs exhibit a significant improvement in the aspects of mucus penetration and transepithelial transport, which is related to the protein species of SC. This study demonstrates that SC@DS NPs can efficiently overcome multiple biological barriers and improve the therapeutic effect.https://doi.org/10.1186/s12951-023-01995-zBiomimetic sporeOral drug deliverySpore capsidBiological barrier |
| spellingShingle | Qingling Song Junfei Yang Xiaocui Wu Yao Li Hongjuan Zhao Qianhua Feng Zhenzhong Zhang Yun Zhang Lei Wang A multifunctional integrated biomimetic spore nanoplatform for successively overcoming oral biological barriers Journal of Nanobiotechnology Biomimetic spore Oral drug delivery Spore capsid Biological barrier |
| title | A multifunctional integrated biomimetic spore nanoplatform for successively overcoming oral biological barriers |
| title_full | A multifunctional integrated biomimetic spore nanoplatform for successively overcoming oral biological barriers |
| title_fullStr | A multifunctional integrated biomimetic spore nanoplatform for successively overcoming oral biological barriers |
| title_full_unstemmed | A multifunctional integrated biomimetic spore nanoplatform for successively overcoming oral biological barriers |
| title_short | A multifunctional integrated biomimetic spore nanoplatform for successively overcoming oral biological barriers |
| title_sort | multifunctional integrated biomimetic spore nanoplatform for successively overcoming oral biological barriers |
| topic | Biomimetic spore Oral drug delivery Spore capsid Biological barrier |
| url | https://doi.org/10.1186/s12951-023-01995-z |
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