Environmentally Friendly Strategies for Formulating Vegetable Oil-Based Nanoparticles for Anticancer Medicine
The development of green synthesized polymeric nanoparticles with anticancer studies has been an emerging field in academia and the pharmaceutical and chemical industries. Vegetable oils are potential substitutes for petroleum derivatives, as they present a clean and environmentally friendly alterna...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/7/1908 |
| _version_ | 1797587775470436352 |
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| author | Nathália Freire Raquel de Melo Barbosa Fátima García-Villén César Viseras Luana Perioli Rosana Fialho Elaine Albuquerque |
| author_facet | Nathália Freire Raquel de Melo Barbosa Fátima García-Villén César Viseras Luana Perioli Rosana Fialho Elaine Albuquerque |
| author_sort | Nathália Freire |
| collection | DOAJ |
| description | The development of green synthesized polymeric nanoparticles with anticancer studies has been an emerging field in academia and the pharmaceutical and chemical industries. Vegetable oils are potential substitutes for petroleum derivatives, as they present a clean and environmentally friendly alternative and are available in abundance at relatively low prices. Biomass-derived chemicals can be converted into monomers with a unique structure, generating materials with new properties for the synthesis of sustainable monomers and polymers. The production of bio-based polymeric nanoparticles is a promising application of green chemistry for biomedical uses. There is an increasing demand for biocompatible and biodegradable materials for specific applications in the biomedical area, such as cancer therapy. This is encouraging scientists to work on research toward designing polymers with enhanced properties and clean processes, containing oncology active pharmaceutical ingredients (APIs). The nanoencapsulation of these APIs in bio-based polymeric nanoparticles can control the release of the substances, increase bioavailability, reduce problems of volatility and degradation, reduce side effects, and increase treatment efficiency. This review discusses the use of green chemistry for bio-based nanoparticle production and its application in anticancer medicine. The use of castor oil for the production of renewable monomers and polymers is proposed as an ideal candidate for such applications, as well as more suitable methods for the production of bio-based nanoparticles and some oncology APIs available for anticancer application. |
| first_indexed | 2024-03-11T00:43:40Z |
| format | Article |
| id | doaj.art-208e02871c634f9e8bdf194b2b016202 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T00:43:40Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-208e02871c634f9e8bdf194b2b0162022023-11-18T20:55:31ZengMDPI AGPharmaceutics1999-49232023-07-01157190810.3390/pharmaceutics15071908Environmentally Friendly Strategies for Formulating Vegetable Oil-Based Nanoparticles for Anticancer MedicineNathália Freire0Raquel de Melo Barbosa1Fátima García-Villén2César Viseras3Luana Perioli4Rosana Fialho5Elaine Albuquerque6Graduate Program in Industrial Engineering, Polytechnic School, Federal University of Bahia, Salvador 40210-630, BrazilLaboratory of Drug Development, Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, BrazilDepartment of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Campus of Cartuja, 18071 Granada, SpainDepartment of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Campus of Cartuja, 18071 Granada, SpainDepartment of Pharmaceutic Science, University of Perugia, 06123 Perugia, ItalyGraduate Program in Industrial Engineering, Polytechnic School, Federal University of Bahia, Salvador 40210-630, BrazilGraduate Program in Industrial Engineering, Polytechnic School, Federal University of Bahia, Salvador 40210-630, BrazilThe development of green synthesized polymeric nanoparticles with anticancer studies has been an emerging field in academia and the pharmaceutical and chemical industries. Vegetable oils are potential substitutes for petroleum derivatives, as they present a clean and environmentally friendly alternative and are available in abundance at relatively low prices. Biomass-derived chemicals can be converted into monomers with a unique structure, generating materials with new properties for the synthesis of sustainable monomers and polymers. The production of bio-based polymeric nanoparticles is a promising application of green chemistry for biomedical uses. There is an increasing demand for biocompatible and biodegradable materials for specific applications in the biomedical area, such as cancer therapy. This is encouraging scientists to work on research toward designing polymers with enhanced properties and clean processes, containing oncology active pharmaceutical ingredients (APIs). The nanoencapsulation of these APIs in bio-based polymeric nanoparticles can control the release of the substances, increase bioavailability, reduce problems of volatility and degradation, reduce side effects, and increase treatment efficiency. This review discusses the use of green chemistry for bio-based nanoparticle production and its application in anticancer medicine. The use of castor oil for the production of renewable monomers and polymers is proposed as an ideal candidate for such applications, as well as more suitable methods for the production of bio-based nanoparticles and some oncology APIs available for anticancer application.https://www.mdpi.com/1999-4923/15/7/1908green chemistryvegetable oilsbio-based nanoparticlesoncology APIs |
| spellingShingle | Nathália Freire Raquel de Melo Barbosa Fátima García-Villén César Viseras Luana Perioli Rosana Fialho Elaine Albuquerque Environmentally Friendly Strategies for Formulating Vegetable Oil-Based Nanoparticles for Anticancer Medicine Pharmaceutics green chemistry vegetable oils bio-based nanoparticles oncology APIs |
| title | Environmentally Friendly Strategies for Formulating Vegetable Oil-Based Nanoparticles for Anticancer Medicine |
| title_full | Environmentally Friendly Strategies for Formulating Vegetable Oil-Based Nanoparticles for Anticancer Medicine |
| title_fullStr | Environmentally Friendly Strategies for Formulating Vegetable Oil-Based Nanoparticles for Anticancer Medicine |
| title_full_unstemmed | Environmentally Friendly Strategies for Formulating Vegetable Oil-Based Nanoparticles for Anticancer Medicine |
| title_short | Environmentally Friendly Strategies for Formulating Vegetable Oil-Based Nanoparticles for Anticancer Medicine |
| title_sort | environmentally friendly strategies for formulating vegetable oil based nanoparticles for anticancer medicine |
| topic | green chemistry vegetable oils bio-based nanoparticles oncology APIs |
| url | https://www.mdpi.com/1999-4923/15/7/1908 |
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