Pediatric cancer gone viral. Part II: potential clinical application of oncolytic herpes simplex virus-1 in children
Oncolytic engineered herpes simplex viruses (HSVs) possess many biologic and functional attributes that support their use in clinical trials in children with solid tumors. Tumor cells, in an effort to escape regulatory mechanisms that would impair their growth and progression, have removed many mech...
Main Authors: | Gregory K Friedman, Elizabeth A Beierle, George Yancey Gillespie, James M Markert, Alicia M Waters, Chun-Yu Chen, Nicholas L Denton, Kellie B Haworth, Brian Hutzen, Jennifer L Leddon, Keri A Streby, Pin-Yi Wang, Timothy P Cripe |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2015-01-01
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Series: | Molecular Therapy: Oncolytics |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2372770516300183 |
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