Vitis vinifera juice ameliorates depression-like behavior in mice by modulating biogenic amine neurotransmitters
The advantageous effects of Vitis vinifera juice on depressive model mice were examined utilizing a blend of behavioral evaluations and biogenic amine neurotransmitter estimations. During the behavioral evaluations, immobility time on the forced swimming test and tail suspension test were measured i...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2015-09-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/23732 |
| _version_ | 1819135429515935744 |
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| author | Muhammad Aslam Nuzhat Sultana |
| author_facet | Muhammad Aslam Nuzhat Sultana |
| author_sort | Muhammad Aslam |
| collection | DOAJ |
| description | The advantageous effects of Vitis vinifera juice on depressive model mice were examined utilizing a blend of behavioral evaluations and biogenic amine neurotransmitter estimations. During the behavioral evaluations, immobility time on the forced swimming test and tail suspension test were measured in unstressed and immobilization-induced stressed mice. V. vinifera juice (4 mL/kg and 8 mL/kg) and fluoxetine (20 mg/kg) produced a significant decrease in immobility time of both unstressed and stressed mice when compared with their respective saline-treated control groups in both paradigms. Neurotransmitters were measured using high-performance liquid chromatography with electrochemical detector. V. vinifera juice raised the levels of both serotonin (p<0.001) and noradrenalin (p<0.001) in brain tissue. These outcomes give significant mechanistic insights into the protective effect of V. vinifera juice against depressive disorders. Our results showed that V. vinifera juice could relieve depressive manifestations in the rodent model of depression. |
| first_indexed | 2024-12-22T10:18:57Z |
| format | Article |
| id | doaj.art-20906305c9a84394b4d96b27ae86c6f7 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-22T10:18:57Z |
| publishDate | 2015-09-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-20906305c9a84394b4d96b27ae86c6f72022-12-21T18:29:40ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882015-09-0110410.3329/bjp.v10i4.23732Vitis vinifera juice ameliorates depression-like behavior in mice by modulating biogenic amine neurotransmittersMuhammad Aslam0Nuzhat Sultana1Department of Pharmacology, Faculty of Pharmacy, University of Karachi, KarachiDepartment of Pharmacology, Faculty of Pharmacy, University of Karachi, KarachiThe advantageous effects of Vitis vinifera juice on depressive model mice were examined utilizing a blend of behavioral evaluations and biogenic amine neurotransmitter estimations. During the behavioral evaluations, immobility time on the forced swimming test and tail suspension test were measured in unstressed and immobilization-induced stressed mice. V. vinifera juice (4 mL/kg and 8 mL/kg) and fluoxetine (20 mg/kg) produced a significant decrease in immobility time of both unstressed and stressed mice when compared with their respective saline-treated control groups in both paradigms. Neurotransmitters were measured using high-performance liquid chromatography with electrochemical detector. V. vinifera juice raised the levels of both serotonin (p<0.001) and noradrenalin (p<0.001) in brain tissue. These outcomes give significant mechanistic insights into the protective effect of V. vinifera juice against depressive disorders. Our results showed that V. vinifera juice could relieve depressive manifestations in the rodent model of depression.https://www.banglajol.info/index.php/BJP/article/view/23732DepressionForced swimming testTail suspension testVitis vinifera |
| spellingShingle | Muhammad Aslam Nuzhat Sultana Vitis vinifera juice ameliorates depression-like behavior in mice by modulating biogenic amine neurotransmitters Bangladesh Journal of Pharmacology Depression Forced swimming test Tail suspension test Vitis vinifera |
| title | Vitis vinifera juice ameliorates depression-like behavior in mice by modulating biogenic amine neurotransmitters |
| title_full | Vitis vinifera juice ameliorates depression-like behavior in mice by modulating biogenic amine neurotransmitters |
| title_fullStr | Vitis vinifera juice ameliorates depression-like behavior in mice by modulating biogenic amine neurotransmitters |
| title_full_unstemmed | Vitis vinifera juice ameliorates depression-like behavior in mice by modulating biogenic amine neurotransmitters |
| title_short | Vitis vinifera juice ameliorates depression-like behavior in mice by modulating biogenic amine neurotransmitters |
| title_sort | vitis vinifera juice ameliorates depression like behavior in mice by modulating biogenic amine neurotransmitters |
| topic | Depression Forced swimming test Tail suspension test Vitis vinifera |
| url | https://www.banglajol.info/index.php/BJP/article/view/23732 |
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