Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida
Abstract To enrich the bioactive cycloartane triterpenoid glycoside named actein and find out more cytotoxic cycloartane triterpenes, a phytochemical study of Cimicifuga foetida was conducted. 113 g (0.17%) actein was purified by recrystallization while eight cycloartane-type triterpenes (1–8) were...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-06-01
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| Series: | Natural Products and Bioprospecting |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s13659-019-0214-1 |
| _version_ | 1818031465238102016 |
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| author | Jing Lu Xing-Rong Peng Da-Shan Li Qiang-Qiang Shi Ming-Hua Qiu |
| author_facet | Jing Lu Xing-Rong Peng Da-Shan Li Qiang-Qiang Shi Ming-Hua Qiu |
| author_sort | Jing Lu |
| collection | DOAJ |
| description | Abstract To enrich the bioactive cycloartane triterpenoid glycoside named actein and find out more cytotoxic cycloartane triterpenes, a phytochemical study of Cimicifuga foetida was conducted. 113 g (0.17%) actein was purified by recrystallization while eight cycloartane-type triterpenes (1–8) were isolated from the mother liquid. The chemical structures of new compounds (1–4) were elucidated by 1D and 2D NMR and HRESIMS spectroscopic analyses. Moreover, new compounds showed moderate and broad-spectrum cytotoxicity against 5 human cancer cell lines with IC50 values ranging from 4.02 to 15.80 μM. Graphic Abstract |
| first_indexed | 2024-12-10T05:51:54Z |
| format | Article |
| id | doaj.art-2093118c4cc44f52b17ae51ff33a1123 |
| institution | Directory Open Access Journal |
| issn | 2192-2195 2192-2209 |
| language | English |
| last_indexed | 2024-12-10T05:51:54Z |
| publishDate | 2019-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Natural Products and Bioprospecting |
| spelling | doaj.art-2093118c4cc44f52b17ae51ff33a11232022-12-22T02:00:01ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092019-06-019430331010.1007/s13659-019-0214-1Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetidaJing Lu0Xing-Rong Peng1Da-Shan Li2Qiang-Qiang Shi3Ming-Hua Qiu4State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS)State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS)State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS)State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS)State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS)Abstract To enrich the bioactive cycloartane triterpenoid glycoside named actein and find out more cytotoxic cycloartane triterpenes, a phytochemical study of Cimicifuga foetida was conducted. 113 g (0.17%) actein was purified by recrystallization while eight cycloartane-type triterpenes (1–8) were isolated from the mother liquid. The chemical structures of new compounds (1–4) were elucidated by 1D and 2D NMR and HRESIMS spectroscopic analyses. Moreover, new compounds showed moderate and broad-spectrum cytotoxicity against 5 human cancer cell lines with IC50 values ranging from 4.02 to 15.80 μM. Graphic Abstracthttp://link.springer.com/article/10.1007/s13659-019-0214-1Cimicifuga foetidaCycloartane triterpenoid saponinsCytotoxic activity |
| spellingShingle | Jing Lu Xing-Rong Peng Da-Shan Li Qiang-Qiang Shi Ming-Hua Qiu Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida Natural Products and Bioprospecting Cimicifuga foetida Cycloartane triterpenoid saponins Cytotoxic activity |
| title | Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida |
| title_full | Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida |
| title_fullStr | Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida |
| title_full_unstemmed | Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida |
| title_short | Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida |
| title_sort | cytotoxic cycloartane triterpenoid saponins from the rhizomes of cimicifuga foetida |
| topic | Cimicifuga foetida Cycloartane triterpenoid saponins Cytotoxic activity |
| url | http://link.springer.com/article/10.1007/s13659-019-0214-1 |
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