Targeting T cell metabolism in the tumor microenvironment: an anti-cancer therapeutic strategy
Abstract T cells play important roles in anti-tumor immunity. Emerging evidence has revealed that distinct metabolic changes impact the activation and differentiation of T cells. Tailoring immune responses by manipulating cellular metabolic pathways and the identification of new targets may provide...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-09-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13046-019-1409-3 |
| _version_ | 1818922686913445888 |
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| author | Zhongping Yin Ling Bai Wei Li Tanlun Zeng Huimin Tian Jiuwei Cui |
| author_facet | Zhongping Yin Ling Bai Wei Li Tanlun Zeng Huimin Tian Jiuwei Cui |
| author_sort | Zhongping Yin |
| collection | DOAJ |
| description | Abstract T cells play important roles in anti-tumor immunity. Emerging evidence has revealed that distinct metabolic changes impact the activation and differentiation of T cells. Tailoring immune responses by manipulating cellular metabolic pathways and the identification of new targets may provide new options for cancer immunotherapy. In this review, we focus on recent advances in the metabolic reprogramming of different subtypes of T cells and T cell functions. We summarize how metabolic pathways accurately regulate T cell development, differentiation, and function in the tumor microenvironment. Because of the similar metabolism in activated T cells and tumor cells, we also describe the effect of the tumor microenvironment on T cell metabolism reprogramming, which may provide strategies for maximal anti-cancer effects and enhancing the immunity of T cells. Thus, studies of T lymphocyte metabolism can not only facilitate the basic research of immune metabolism, but also provide potential targets for drug development and new strategies for clinical treatment of cancer. |
| first_indexed | 2024-12-20T01:57:30Z |
| format | Article |
| id | doaj.art-2095d87cc381439fb275bba967ccf70b |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-12-20T01:57:30Z |
| publishDate | 2019-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-2095d87cc381439fb275bba967ccf70b2022-12-21T19:57:27ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662019-09-0138111010.1186/s13046-019-1409-3Targeting T cell metabolism in the tumor microenvironment: an anti-cancer therapeutic strategyZhongping Yin0Ling Bai1Wei Li2Tanlun Zeng3Huimin Tian4Jiuwei Cui5Cancer Center, The First Hospital of Jilin UniversityCancer Center, The First Hospital of Jilin UniversityCancer Center, The First Hospital of Jilin UniversityCancer Center, The First Hospital of Jilin UniversityCancer Center, The First Hospital of Jilin UniversityCancer Center, The First Hospital of Jilin UniversityAbstract T cells play important roles in anti-tumor immunity. Emerging evidence has revealed that distinct metabolic changes impact the activation and differentiation of T cells. Tailoring immune responses by manipulating cellular metabolic pathways and the identification of new targets may provide new options for cancer immunotherapy. In this review, we focus on recent advances in the metabolic reprogramming of different subtypes of T cells and T cell functions. We summarize how metabolic pathways accurately regulate T cell development, differentiation, and function in the tumor microenvironment. Because of the similar metabolism in activated T cells and tumor cells, we also describe the effect of the tumor microenvironment on T cell metabolism reprogramming, which may provide strategies for maximal anti-cancer effects and enhancing the immunity of T cells. Thus, studies of T lymphocyte metabolism can not only facilitate the basic research of immune metabolism, but also provide potential targets for drug development and new strategies for clinical treatment of cancer.http://link.springer.com/article/10.1186/s13046-019-1409-3T cellImmunotherapyCancerMetabolic reprogramming |
| spellingShingle | Zhongping Yin Ling Bai Wei Li Tanlun Zeng Huimin Tian Jiuwei Cui Targeting T cell metabolism in the tumor microenvironment: an anti-cancer therapeutic strategy Journal of Experimental & Clinical Cancer Research T cell Immunotherapy Cancer Metabolic reprogramming |
| title | Targeting T cell metabolism in the tumor microenvironment: an anti-cancer therapeutic strategy |
| title_full | Targeting T cell metabolism in the tumor microenvironment: an anti-cancer therapeutic strategy |
| title_fullStr | Targeting T cell metabolism in the tumor microenvironment: an anti-cancer therapeutic strategy |
| title_full_unstemmed | Targeting T cell metabolism in the tumor microenvironment: an anti-cancer therapeutic strategy |
| title_short | Targeting T cell metabolism in the tumor microenvironment: an anti-cancer therapeutic strategy |
| title_sort | targeting t cell metabolism in the tumor microenvironment an anti cancer therapeutic strategy |
| topic | T cell Immunotherapy Cancer Metabolic reprogramming |
| url | http://link.springer.com/article/10.1186/s13046-019-1409-3 |
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