Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells
MiRNAs represent a mechanism that regulates gene expression in many pathological conditions. Exosomes are known to be secreted from all types of cells, and the exosomes-released molecules are crucial messengers that can regulate cellular processes. We investigated the miRNAs content of exosomes rele...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-01-01
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| Series: | Cell Adhesion & Migration |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19336918.2021.1935407 |
| _version_ | 1828944274945736704 |
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| author | Francesca Lessi Paolo Aretini Milena Rizzo Mariangela Morelli Michele Menicagli Sara Franceschi Chiara Maria Mazzanti |
| author_facet | Francesca Lessi Paolo Aretini Milena Rizzo Mariangela Morelli Michele Menicagli Sara Franceschi Chiara Maria Mazzanti |
| author_sort | Francesca Lessi |
| collection | DOAJ |
| description | MiRNAs represent a mechanism that regulates gene expression in many pathological conditions. Exosomes are known to be secreted from all types of cells, and the exosomes-released molecules are crucial messengers that can regulate cellular processes. We investigated the miRNAs content of exosomes released by cancer cells during the invasion . An invasion stimulus has been generated through scratches created on the confluent cells of cancer cell lines: glioblastoma, breast and prostate cancers. Several miRNAs were found to be significantly differentially abundant during the cell invasion , both in common among different cell lines and exclusive. Understanding the language codes among cells involved in invasion can lead to the development of therapies that can inhibit cellular communication, slowing or eventually stopping their activity. |
| first_indexed | 2024-12-14T04:30:48Z |
| format | Article |
| id | doaj.art-209d36481a1b4066acb80f61c70be561 |
| institution | Directory Open Access Journal |
| issn | 1933-6918 1933-6926 |
| language | English |
| last_indexed | 2024-12-14T04:30:48Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cell Adhesion & Migration |
| spelling | doaj.art-209d36481a1b4066acb80f61c70be5612022-12-21T23:17:05ZengTaylor & Francis GroupCell Adhesion & Migration1933-69181933-69262021-01-0115118020110.1080/19336918.2021.19354071935407Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cellsFrancesca Lessi0Paolo Aretini1Milena Rizzo2Mariangela Morelli3Michele Menicagli4Sara Franceschi5Chiara Maria Mazzanti6Fondazione Pisana per La ScienzaFondazione Pisana per La ScienzaInstitute of Clinical Physiology (IFC)Fondazione Pisana per La ScienzaFondazione Pisana per La ScienzaFondazione Pisana per La ScienzaFondazione Pisana per La ScienzaMiRNAs represent a mechanism that regulates gene expression in many pathological conditions. Exosomes are known to be secreted from all types of cells, and the exosomes-released molecules are crucial messengers that can regulate cellular processes. We investigated the miRNAs content of exosomes released by cancer cells during the invasion . An invasion stimulus has been generated through scratches created on the confluent cells of cancer cell lines: glioblastoma, breast and prostate cancers. Several miRNAs were found to be significantly differentially abundant during the cell invasion , both in common among different cell lines and exclusive. Understanding the language codes among cells involved in invasion can lead to the development of therapies that can inhibit cellular communication, slowing or eventually stopping their activity.http://dx.doi.org/10.1080/19336918.2021.1935407exosomesmirnastumor invasionbreast cancerglioblastomaprostate cancer |
| spellingShingle | Francesca Lessi Paolo Aretini Milena Rizzo Mariangela Morelli Michele Menicagli Sara Franceschi Chiara Maria Mazzanti Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells Cell Adhesion & Migration exosomes mirnas tumor invasion breast cancer glioblastoma prostate cancer |
| title | Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells |
| title_full | Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells |
| title_fullStr | Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells |
| title_full_unstemmed | Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells |
| title_short | Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells |
| title_sort | analysis of exosome derived micrornas reveals insights of intercellular communication during invasion of breast prostate and glioblastoma cancer cells |
| topic | exosomes mirnas tumor invasion breast cancer glioblastoma prostate cancer |
| url | http://dx.doi.org/10.1080/19336918.2021.1935407 |
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