Insulin-like Growth Factor-1, Psoriasis, and Inflammation: A Ménage à Trois?
Psoriatic patients have an accumulation of metabolic syndrome (MS) and cardiovascular diseases (CVD), likely mediated by systemic inflammation, and exhibiting low circulating levels of insulin-like growth factor (IGF)-I, a marker of MS and CVD in the general population. The aim of this study is to d...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2011-09-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X1100900308 |
| _version_ | 1818333430712107008 |
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| author | S. Savastano N. Balato F. Gaudiello C. Di Somma V. Brancato A. Colao F. Ayala G. Tarantino |
| author_facet | S. Savastano N. Balato F. Gaudiello C. Di Somma V. Brancato A. Colao F. Ayala G. Tarantino |
| author_sort | S. Savastano |
| collection | DOAJ |
| description | Psoriatic patients have an accumulation of metabolic syndrome (MS) and cardiovascular diseases (CVD), likely mediated by systemic inflammation, and exhibiting low circulating levels of insulin-like growth factor (IGF)-I, a marker of MS and CVD in the general population. The aim of this study is to determine the association of IGF-I and inflammation, and to assess the cardio-metabolic risk calculating the visceral adiposity index (VAI), in a group of psoriatic patients without MS. IGF-I, fibrinogen, C-reactive protein (CRP), and interleukin (IL)-6 levels were determined in 20 patients with moderate to severe psoriasis (age range 23–77 yrs) without MS, according to criteria of the National Cholesterol Education Program's Adult Panel III (ATP III), and 20 age- and BMI-matched controls. The standard deviation score (SDS) of IGF-I levels according to age (zSDS), the homeostasis model assessment of insulin resistance (HOMA-IR), the whole-body insulin sensitivity index (ISI), and VAI were also calculated. Psoriasis Area and Severity Index (PASI) mean value was 17.8±11. HDL cholesterol and IGF-I zSDS values were lower (p<0.001) and waist circumference (p<0.001), VAI, fibrinogen, and IL-6 (p<0.005) were higher compared with controls, while HOMA-IR and ISI were not statistically different. Lower IGF-I zSDS values were associated to higher values of BMI (p=0.04), waist circumference, VAI (p<0.001), PASI (p=0.011), or IL-6 (p<0.001). At the multivariate analysis PASI was the major determinant of IGF-I zSDS (p=0.016), accounting for 37% of its variability. In a subset of psoriatic patients without MS, chronic inflammation might be an important modulator of low IGF-I status, as a further possible mechanistic link between psoriasis and associated metabolic co-morbidities. The negative correlation between age-related IGF-I values and VAI suggest the involvement of adipocyte dysfunction in low IGF-I status more than MS per se . Further studies are needed to address whether these results are valid also for other psoriatic patients. |
| first_indexed | 2024-12-13T13:51:31Z |
| format | Article |
| id | doaj.art-209de3ada95f41c2ab7f0c891b86aac0 |
| institution | Directory Open Access Journal |
| issn | 1721-727X |
| language | English |
| last_indexed | 2024-12-13T13:51:31Z |
| publishDate | 2011-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-209de3ada95f41c2ab7f0c891b86aac02022-12-21T23:43:07ZengSAGE PublishingEuropean Journal of Inflammation1721-727X2011-09-01910.1177/1721727X1100900308Insulin-like Growth Factor-1, Psoriasis, and Inflammation: A Ménage à Trois?S. Savastano0N. Balato1F. Gaudiello2C. Di Somma3V. Brancato4A. Colao5F. Ayala6G. Tarantino7 Department of Molecular and Clinical Endocrinology and Oncology, Division of Endocrinology, Federico II University Medical School of Naples Department of Systematic Pathology, Division of Clinical Dermatology, Federico II University Medical School of Naples Department of Systematic Pathology, Division of Clinical Dermatology, Federico II University Medical School of Naples IRCCS SDN Foundation, Naples Department of Molecular and Clinical Endocrinology and Oncology, Division of Endocrinology, Federico II University Medical School of Naples Department of Molecular and Clinical Endocrinology and Oncology, Division of Endocrinology, Federico II University Medical School of Naples Department of Systematic Pathology, Division of Clinical Dermatology, Federico II University Medical School of Naples Department of Clinical and Experimental Medicine, Federico II University Medical School of Naples, ItalyPsoriatic patients have an accumulation of metabolic syndrome (MS) and cardiovascular diseases (CVD), likely mediated by systemic inflammation, and exhibiting low circulating levels of insulin-like growth factor (IGF)-I, a marker of MS and CVD in the general population. The aim of this study is to determine the association of IGF-I and inflammation, and to assess the cardio-metabolic risk calculating the visceral adiposity index (VAI), in a group of psoriatic patients without MS. IGF-I, fibrinogen, C-reactive protein (CRP), and interleukin (IL)-6 levels were determined in 20 patients with moderate to severe psoriasis (age range 23–77 yrs) without MS, according to criteria of the National Cholesterol Education Program's Adult Panel III (ATP III), and 20 age- and BMI-matched controls. The standard deviation score (SDS) of IGF-I levels according to age (zSDS), the homeostasis model assessment of insulin resistance (HOMA-IR), the whole-body insulin sensitivity index (ISI), and VAI were also calculated. Psoriasis Area and Severity Index (PASI) mean value was 17.8±11. HDL cholesterol and IGF-I zSDS values were lower (p<0.001) and waist circumference (p<0.001), VAI, fibrinogen, and IL-6 (p<0.005) were higher compared with controls, while HOMA-IR and ISI were not statistically different. Lower IGF-I zSDS values were associated to higher values of BMI (p=0.04), waist circumference, VAI (p<0.001), PASI (p=0.011), or IL-6 (p<0.001). At the multivariate analysis PASI was the major determinant of IGF-I zSDS (p=0.016), accounting for 37% of its variability. In a subset of psoriatic patients without MS, chronic inflammation might be an important modulator of low IGF-I status, as a further possible mechanistic link between psoriasis and associated metabolic co-morbidities. The negative correlation between age-related IGF-I values and VAI suggest the involvement of adipocyte dysfunction in low IGF-I status more than MS per se . Further studies are needed to address whether these results are valid also for other psoriatic patients.https://doi.org/10.1177/1721727X1100900308 |
| spellingShingle | S. Savastano N. Balato F. Gaudiello C. Di Somma V. Brancato A. Colao F. Ayala G. Tarantino Insulin-like Growth Factor-1, Psoriasis, and Inflammation: A Ménage à Trois? European Journal of Inflammation |
| title | Insulin-like Growth Factor-1, Psoriasis, and Inflammation: A Ménage à
Trois? |
| title_full | Insulin-like Growth Factor-1, Psoriasis, and Inflammation: A Ménage à
Trois? |
| title_fullStr | Insulin-like Growth Factor-1, Psoriasis, and Inflammation: A Ménage à
Trois? |
| title_full_unstemmed | Insulin-like Growth Factor-1, Psoriasis, and Inflammation: A Ménage à
Trois? |
| title_short | Insulin-like Growth Factor-1, Psoriasis, and Inflammation: A Ménage à
Trois? |
| title_sort | insulin like growth factor 1 psoriasis and inflammation a menage a trois |
| url | https://doi.org/10.1177/1721727X1100900308 |
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