A novel method, digital genome scanning detects <it>KRAS </it>gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth

A novel method, digital genome scanning detects <it>KRAS </it>gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth

<p>Abstract</p> <p>Background</p> <p>Gastric cancer is the third most common malignancy affecting the general population worldwide. Aberrant activation of KRAS is a key factor in the development of many types of tumor, however, oncogenic mutations of <it>KRAS <...

Full description

Bibliographic Details
Main Authors: Yanagihara Kazuyoshi, Kashima Lisa, Idogawa Masashi, Suzuki Hiromu, Sasaki Yasushi, Maruyama Reo, Akashi Hirofumi, Aoki Fumio, Toyota Minoru, Mita Hiroaki, Fujita Masahiro, Hosokawa Masao, Kusano Masanobu, Sabau Sorin, Tatsumi Haruyuki, Imai Kohzoh, Shinomura Yasuhisa, Tokino Takashi
Format: Article
Language:English
Published: BMC 2009-06-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/9/198

Internet

http://www.biomedcentral.com/1471-2407/9/198

Similar Items