Investigating the anti-tumoral effect of curcumin on the mice in which Ehrlich ascites and solid tumor is created
Objective(s): In this study, the effects of different doses of curcumin application on Ehrlich ascites tumor (EAT) created in the mice of BALB/c type were investigated.Materials and Methods: Curcumin extracts can have hindering effect on tumor volume, vascular density, EAT cells around the tissues,...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2019-04-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/article_12271_28f10bf181ebf0e93586b61b2f19f02c.pdf |
| _version_ | 1811276072763785216 |
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| author | Seher Yilmaz Harun Ülger Tolga Ertekin Arzu Yay Mehtap Nisari Şerife Alpa Niyazi Acer |
| author_facet | Seher Yilmaz Harun Ülger Tolga Ertekin Arzu Yay Mehtap Nisari Şerife Alpa Niyazi Acer |
| author_sort | Seher Yilmaz |
| collection | DOAJ |
| description | Objective(s): In this study, the effects of different doses of curcumin application on Ehrlich ascites tumor (EAT) created in the mice of BALB/c type were investigated.Materials and Methods: Curcumin extracts can have hindering effect on tumor volume, vascular density, EAT cells around the tissues, and can support apoptosis. EAT cells (1x106) received from stock animals were injected intraperitoneally (IP) and subcutaneously (SC) to the animals. Then, curcumin was administered IP. Doses of 25 mg/kg IP and 50 mg/kg were administered over 10 days to the animals in the treatment groups in which ascites tumor was induced. The same doses were administered over 15 days in the treatment groups in which solid tumor was induced.Results: Histopathological examination in ascites tumor groups revealed that number of EAT cells at surrounding tissues was smaller in the group received 50 mg/kg curcumin when compared to tumor control group (P |
| first_indexed | 2024-04-12T23:49:59Z |
| format | Article |
| id | doaj.art-20a190a52793403e8de03028f74fe1e3 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-04-12T23:49:59Z |
| publishDate | 2019-04-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-20a190a52793403e8de03028f74fe1e32022-12-22T03:11:44ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742019-04-0122441842510.22038/ijbms.2019.33623.801912271Investigating the anti-tumoral effect of curcumin on the mice in which Ehrlich ascites and solid tumor is createdSeher Yilmaz0Harun Ülger1Tolga Ertekin2Arzu Yay3Mehtap Nisari4Şerife Alpa5Niyazi Acer6Department of Anatomy, Yozgat Bozok University Faculty of Medicine, Yozgat, TurkeyDepartment of Anatomy, Erciyes University Faculty of Medicine, Kayseri, TurkeyDepartment of Anatomy, Kocatepe University Faculty of Medicine, Afyon, TurkeyDepartment of Histology, Embriology, Erciyes University Faculty of Medicine, Kayseri, TurkeyDepartment of Anatomy, Erciyes University Faculty of Medicine, Kayseri, TurkeyDepartment of Anatomy, Karatay University Faculty of Medicine, Konya,TurkeyDepartment of Anatomy, Erciyes University Faculty of Medicine, Kayseri, TurkeyObjective(s): In this study, the effects of different doses of curcumin application on Ehrlich ascites tumor (EAT) created in the mice of BALB/c type were investigated.Materials and Methods: Curcumin extracts can have hindering effect on tumor volume, vascular density, EAT cells around the tissues, and can support apoptosis. EAT cells (1x106) received from stock animals were injected intraperitoneally (IP) and subcutaneously (SC) to the animals. Then, curcumin was administered IP. Doses of 25 mg/kg IP and 50 mg/kg were administered over 10 days to the animals in the treatment groups in which ascites tumor was induced. The same doses were administered over 15 days in the treatment groups in which solid tumor was induced.Results: Histopathological examination in ascites tumor groups revealed that number of EAT cells at surrounding tissues was smaller in the group received 50 mg/kg curcumin when compared to tumor control group (Phttp://ijbms.mums.ac.ir/article_12271_28f10bf181ebf0e93586b61b2f19f02c.pdfAnimalApoptosisCellCurcuminFactor VIIIinjectionMice |
| spellingShingle | Seher Yilmaz Harun Ülger Tolga Ertekin Arzu Yay Mehtap Nisari Şerife Alpa Niyazi Acer Investigating the anti-tumoral effect of curcumin on the mice in which Ehrlich ascites and solid tumor is created Iranian Journal of Basic Medical Sciences Animal Apoptosis Cell Curcumin Factor VIII injection Mice |
| title | Investigating the anti-tumoral effect of curcumin on the mice in which Ehrlich ascites and solid tumor is created |
| title_full | Investigating the anti-tumoral effect of curcumin on the mice in which Ehrlich ascites and solid tumor is created |
| title_fullStr | Investigating the anti-tumoral effect of curcumin on the mice in which Ehrlich ascites and solid tumor is created |
| title_full_unstemmed | Investigating the anti-tumoral effect of curcumin on the mice in which Ehrlich ascites and solid tumor is created |
| title_short | Investigating the anti-tumoral effect of curcumin on the mice in which Ehrlich ascites and solid tumor is created |
| title_sort | investigating the anti tumoral effect of curcumin on the mice in which ehrlich ascites and solid tumor is created |
| topic | Animal Apoptosis Cell Curcumin Factor VIII injection Mice |
| url | http://ijbms.mums.ac.ir/article_12271_28f10bf181ebf0e93586b61b2f19f02c.pdf |
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