Paediatric medicine issues and gaps from healthcare workers point of view: survey results and a narrative review from the global accelerator for paediatric formulations project
The WHO Model List of Essential Medicines for Children (EMLc) has not been systematically revised in the last few years. We conducted a survey addressed to healthcare professionals prescribing, preparing, or administering medicines to children and a narrative review to identify problematic paediatri...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1200848/full |
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| author | Elisa Barbieri Elisa Barbieri Chiara Minotti Sara Cavagnis Carlo Giaquinto Carlo Giaquinto Bernadette Cappello Martina Penazzato Marc Lallemant Marc Lallemant |
| author_facet | Elisa Barbieri Elisa Barbieri Chiara Minotti Sara Cavagnis Carlo Giaquinto Carlo Giaquinto Bernadette Cappello Martina Penazzato Marc Lallemant Marc Lallemant |
| author_sort | Elisa Barbieri |
| collection | DOAJ |
| description | The WHO Model List of Essential Medicines for Children (EMLc) has not been systematically revised in the last few years. We conducted a survey addressed to healthcare professionals prescribing, preparing, or administering medicines to children and a narrative review to identify problematic paediatric formulations or missing medicines in all therapeutic fields to inform the review of the EMLc in 2023. A total of 285 physicians (63%), 28 nurses (6%) and 142 pharmacists (31%), mostly working in the hospital setting, reported at least one problematic medicine. 290 medicines were reported as missing (completely or the child-appropriate formulation). The top three most mentioned were ciprofloxacin together with phenobarbital and omeprazole. 387 medicines were reported as problematic (34% were oral liquid formulations, 34% tablets, 18% parenteral preparations. Mostly of the products were antibacterials (27%), cardiovascular medicines (11%) and antivirals (11%). The obtained responses show the perspective of healthcare workers working around the world, particularly in the European region (25%), in the African region (24%), and in the Region of the Americas (19%), with limited representation from Northern Africa and the Middle East. Our results need to be analysed with the outputs of other ongoing works before specific products can enter the WHO-hosted Global Accelerator for Paediatric formulations network prioritisation process. Efforts to develop appropriate formulations for children should be accelerated so that the uncertainties associated with off-label drug preparation and use are minimised, and therapeutic benefits are optimised. |
| first_indexed | 2024-03-12T23:11:15Z |
| format | Article |
| id | doaj.art-20a263b75ba44cb8913651a2f3f1eea0 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-12T23:11:15Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-20a263b75ba44cb8913651a2f3f1eea02023-07-18T01:03:16ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-07-011410.3389/fphar.2023.12008481200848Paediatric medicine issues and gaps from healthcare workers point of view: survey results and a narrative review from the global accelerator for paediatric formulations projectElisa Barbieri0Elisa Barbieri1Chiara Minotti2Sara Cavagnis3Carlo Giaquinto4Carlo Giaquinto5Bernadette Cappello6Martina Penazzato7Marc Lallemant8Marc Lallemant9Division of Pediatric Infectious Diseases, Department of Women’s and Children’s Health, University of Padova, Padova, ItalyPenta—Child Health Research, Padova, ItalyDivision of Pediatric Infectious Diseases, Department of Women’s and Children’s Health, University of Padova, Padova, ItalyPenta—Child Health Research, Padova, ItalyDivision of Pediatric Infectious Diseases, Department of Women’s and Children’s Health, University of Padova, Padova, ItalyPenta—Child Health Research, Padova, ItalyDepartment of Health Products Policy and Standards, World Health Organization, Geneva, SwitzerlandWHO Research for Health Department, World Health Organization, Geneva, SwitzerlandPenta—Child Health Research, Padova, ItalyFaculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, ThailandThe WHO Model List of Essential Medicines for Children (EMLc) has not been systematically revised in the last few years. We conducted a survey addressed to healthcare professionals prescribing, preparing, or administering medicines to children and a narrative review to identify problematic paediatric formulations or missing medicines in all therapeutic fields to inform the review of the EMLc in 2023. A total of 285 physicians (63%), 28 nurses (6%) and 142 pharmacists (31%), mostly working in the hospital setting, reported at least one problematic medicine. 290 medicines were reported as missing (completely or the child-appropriate formulation). The top three most mentioned were ciprofloxacin together with phenobarbital and omeprazole. 387 medicines were reported as problematic (34% were oral liquid formulations, 34% tablets, 18% parenteral preparations. Mostly of the products were antibacterials (27%), cardiovascular medicines (11%) and antivirals (11%). The obtained responses show the perspective of healthcare workers working around the world, particularly in the European region (25%), in the African region (24%), and in the Region of the Americas (19%), with limited representation from Northern Africa and the Middle East. Our results need to be analysed with the outputs of other ongoing works before specific products can enter the WHO-hosted Global Accelerator for Paediatric formulations network prioritisation process. Efforts to develop appropriate formulations for children should be accelerated so that the uncertainties associated with off-label drug preparation and use are minimised, and therapeutic benefits are optimised.https://www.frontiersin.org/articles/10.3389/fphar.2023.1200848/fullmedicine accessessential medicineschildrenpaediatric formulationsurvey |
| spellingShingle | Elisa Barbieri Elisa Barbieri Chiara Minotti Sara Cavagnis Carlo Giaquinto Carlo Giaquinto Bernadette Cappello Martina Penazzato Marc Lallemant Marc Lallemant Paediatric medicine issues and gaps from healthcare workers point of view: survey results and a narrative review from the global accelerator for paediatric formulations project Frontiers in Pharmacology medicine access essential medicines children paediatric formulation survey |
| title | Paediatric medicine issues and gaps from healthcare workers point of view: survey results and a narrative review from the global accelerator for paediatric formulations project |
| title_full | Paediatric medicine issues and gaps from healthcare workers point of view: survey results and a narrative review from the global accelerator for paediatric formulations project |
| title_fullStr | Paediatric medicine issues and gaps from healthcare workers point of view: survey results and a narrative review from the global accelerator for paediatric formulations project |
| title_full_unstemmed | Paediatric medicine issues and gaps from healthcare workers point of view: survey results and a narrative review from the global accelerator for paediatric formulations project |
| title_short | Paediatric medicine issues and gaps from healthcare workers point of view: survey results and a narrative review from the global accelerator for paediatric formulations project |
| title_sort | paediatric medicine issues and gaps from healthcare workers point of view survey results and a narrative review from the global accelerator for paediatric formulations project |
| topic | medicine access essential medicines children paediatric formulation survey |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1200848/full |
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