Functional Characterization of Colon-Cancer-Associated Variants in <i>ADAM17</i> Affecting the Catalytic Domain

Functional Characterization of Colon-Cancer-Associated Variants in <i>ADAM17</i> Affecting the Catalytic Domain

Although extensively investigated, cancer is still one of the most devastating and lethal diseases in the modern world. Among different types, colorectal cancer (CRC) is most prevalent and mortal, making it an important subject of research. The metalloprotease ADAM17 has been implicated in the devel...

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Bibliographic Details
Main Authors: Jan Philipp Dobert, Anne-Sophie Cabron, Philipp Arnold, Egor Pavlenko, Stefan Rose-John, Friederike Zunke
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Biomedicines
Subjects:
ADAM17
colorectal cancer (CRC)
TNFα
IL-6R
AREG
shedding
Online Access:https://www.mdpi.com/2227-9059/8/11/463

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