Treatment Resulting Changes in Volumes of High-<sup>18</sup>F-FDG-Uptake Adipose Tissues over Orbit and Epicardium Correlate with Treatment Response for Non-Hodgkin’s Lymphoma
Background: A regimen of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is the standard treatment for non-Hodgkin’s lymphoma. Brown adipose tissue possesses anti-cancer potential. This study aimed to explore practical biomarkers for non-Hodgkin’s lymphoma by analyzing...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/3/2158 |
| _version_ | 1797624455291207680 |
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| author | Yu-Ming Huang Chen-Hsi Hsieh Shan-Ying Wang Chin-Ho Tsao Jehn-Chuan Lee Yu-Jen Chen |
| author_facet | Yu-Ming Huang Chen-Hsi Hsieh Shan-Ying Wang Chin-Ho Tsao Jehn-Chuan Lee Yu-Jen Chen |
| author_sort | Yu-Ming Huang |
| collection | DOAJ |
| description | Background: A regimen of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is the standard treatment for non-Hodgkin’s lymphoma. Brown adipose tissue possesses anti-cancer potential. This study aimed to explore practical biomarkers for non-Hodgkin’s lymphoma by analyzing the metabolic activity of adipose tissue. Methods: Twenty patients who received R-CHOP for non-Hodgkin’s lymphoma were reviewed. Positron emission tomography/computed tomography (PET/CT) images, lactate dehydrogenase (LDH) levels, and body mass index (BMI) before and after treatment were collected. Regions with a high standardized uptake value (SUV) in epicardial and orbital adipose tissue were selected and analyzed by a PET/CT viewer. The initial measurements and changes in the high SUV of epicardial and orbital adipose tissues, LDH levels, and BMI of treatment responders and non-responders, and complete and partial responders, were compared. Results: The volumes of high-SUV epicardial and orbital adipose tissues significantly increased in responders after R-CHOP (<i>p</i> = 0.03 and 0.002, respectively). There were significant differences between changes in the high-SUV volumes of epicardial and orbital adipose tissues (<i>p</i> = 0.03 and 0.001, respectively) and LDH levels (<i>p</i> = 0.03) between responders and non-responders. The changes in high-SUV epicardial adipose tissue volumes were greater among complete responders than partial responders (<i>p</i> = 0.04). Poorer treatment responses were observed in patients with lower high-SUV epicardial adipose tissue volumes and higher LDH levels after R-CHOP (<i>p</i> = 0.03 and 0.03, respectively). Conclusions: The preliminary results of greater changes in high-SUV epicardial and orbital adipose tissue volumes among responders indicate that brown adipose tissue could be considered a favorable prognostic biomarker. |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:42:35Z |
| publishDate | 2023-01-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-20a4d1110d124f009c947c291ea87eff2023-11-16T16:53:09ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243215810.3390/ijms24032158Treatment Resulting Changes in Volumes of High-<sup>18</sup>F-FDG-Uptake Adipose Tissues over Orbit and Epicardium Correlate with Treatment Response for Non-Hodgkin’s LymphomaYu-Ming Huang0Chen-Hsi Hsieh1Shan-Ying Wang2Chin-Ho Tsao3Jehn-Chuan Lee4Yu-Jen Chen5Department of Radiation Oncology, Taipei Hospital, Ministry of Health and Welfare, New Taipei City 242, TaiwanInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 112, TaiwanDepartment of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei 112, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei City 252, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei City 252, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei City 252, TaiwanBackground: A regimen of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is the standard treatment for non-Hodgkin’s lymphoma. Brown adipose tissue possesses anti-cancer potential. This study aimed to explore practical biomarkers for non-Hodgkin’s lymphoma by analyzing the metabolic activity of adipose tissue. Methods: Twenty patients who received R-CHOP for non-Hodgkin’s lymphoma were reviewed. Positron emission tomography/computed tomography (PET/CT) images, lactate dehydrogenase (LDH) levels, and body mass index (BMI) before and after treatment were collected. Regions with a high standardized uptake value (SUV) in epicardial and orbital adipose tissue were selected and analyzed by a PET/CT viewer. The initial measurements and changes in the high SUV of epicardial and orbital adipose tissues, LDH levels, and BMI of treatment responders and non-responders, and complete and partial responders, were compared. Results: The volumes of high-SUV epicardial and orbital adipose tissues significantly increased in responders after R-CHOP (<i>p</i> = 0.03 and 0.002, respectively). There were significant differences between changes in the high-SUV volumes of epicardial and orbital adipose tissues (<i>p</i> = 0.03 and 0.001, respectively) and LDH levels (<i>p</i> = 0.03) between responders and non-responders. The changes in high-SUV epicardial adipose tissue volumes were greater among complete responders than partial responders (<i>p</i> = 0.04). Poorer treatment responses were observed in patients with lower high-SUV epicardial adipose tissue volumes and higher LDH levels after R-CHOP (<i>p</i> = 0.03 and 0.03, respectively). Conclusions: The preliminary results of greater changes in high-SUV epicardial and orbital adipose tissue volumes among responders indicate that brown adipose tissue could be considered a favorable prognostic biomarker.https://www.mdpi.com/1422-0067/24/3/2158brown adipose tissueepicardiumorbitnon-Hodgkin’s lymphomaR-CHOPPET/CT |
| spellingShingle | Yu-Ming Huang Chen-Hsi Hsieh Shan-Ying Wang Chin-Ho Tsao Jehn-Chuan Lee Yu-Jen Chen Treatment Resulting Changes in Volumes of High-<sup>18</sup>F-FDG-Uptake Adipose Tissues over Orbit and Epicardium Correlate with Treatment Response for Non-Hodgkin’s Lymphoma International Journal of Molecular Sciences brown adipose tissue epicardium orbit non-Hodgkin’s lymphoma R-CHOP PET/CT |
| title | Treatment Resulting Changes in Volumes of High-<sup>18</sup>F-FDG-Uptake Adipose Tissues over Orbit and Epicardium Correlate with Treatment Response for Non-Hodgkin’s Lymphoma |
| title_full | Treatment Resulting Changes in Volumes of High-<sup>18</sup>F-FDG-Uptake Adipose Tissues over Orbit and Epicardium Correlate with Treatment Response for Non-Hodgkin’s Lymphoma |
| title_fullStr | Treatment Resulting Changes in Volumes of High-<sup>18</sup>F-FDG-Uptake Adipose Tissues over Orbit and Epicardium Correlate with Treatment Response for Non-Hodgkin’s Lymphoma |
| title_full_unstemmed | Treatment Resulting Changes in Volumes of High-<sup>18</sup>F-FDG-Uptake Adipose Tissues over Orbit and Epicardium Correlate with Treatment Response for Non-Hodgkin’s Lymphoma |
| title_short | Treatment Resulting Changes in Volumes of High-<sup>18</sup>F-FDG-Uptake Adipose Tissues over Orbit and Epicardium Correlate with Treatment Response for Non-Hodgkin’s Lymphoma |
| title_sort | treatment resulting changes in volumes of high sup 18 sup f fdg uptake adipose tissues over orbit and epicardium correlate with treatment response for non hodgkin s lymphoma |
| topic | brown adipose tissue epicardium orbit non-Hodgkin’s lymphoma R-CHOP PET/CT |
| url | https://www.mdpi.com/1422-0067/24/3/2158 |
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