Bioactive Diterpenoids Obtained from <i>Grindelia ventanensis</i> Bartola & Tortosa (Asteraceae)
<i>Grindelia ventanensis</i> (Asteraceae) is an endemic species growing wild in Argentina. In this work, we studied the dichloromethane extract of this plant for their antioxidant activity and cholinesterase inhibition. This extract was fractionated using column chromatography and HPLC....
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Chemistry Proceedings |
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| Online Access: | https://www.mdpi.com/2673-4583/12/1/71 |
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| author | Silvana Andrea Rodriguez Marilyn Velasco Elena Corbalán Córdoba Ana Paula Murray |
| author_facet | Silvana Andrea Rodriguez Marilyn Velasco Elena Corbalán Córdoba Ana Paula Murray |
| author_sort | Silvana Andrea Rodriguez |
| collection | DOAJ |
| description | <i>Grindelia ventanensis</i> (Asteraceae) is an endemic species growing wild in Argentina. In this work, we studied the dichloromethane extract of this plant for their antioxidant activity and cholinesterase inhibition. This extract was fractionated using column chromatography and HPLC. Six diterpenoids were isolated and identified using RMN and MS analyses. The 13-methyl-17-oxo-labda-7,13-diene-15-oic acid elicited the best results in both bioassays, with IC<sub>50</sub> = 11.04 µM in the AChE inhibition test and an antioxidant activity comparable to trolox, the reference antioxidant (IC<sub>50</sub> = 7.13 µM). Significant bioactivity was also observed for the rest of the isolated compounds. |
| first_indexed | 2024-03-11T02:37:34Z |
| format | Article |
| id | doaj.art-20a79ff13fbf41d6bdffe57243f2613c |
| institution | Directory Open Access Journal |
| issn | 2673-4583 |
| language | English |
| last_indexed | 2024-03-11T02:37:34Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
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| series | Chemistry Proceedings |
| spelling | doaj.art-20a79ff13fbf41d6bdffe57243f2613c2023-11-18T09:48:33ZengMDPI AGChemistry Proceedings2673-45832022-11-011217110.3390/ecsoc-26-13581Bioactive Diterpenoids Obtained from <i>Grindelia ventanensis</i> Bartola & Tortosa (Asteraceae)Silvana Andrea Rodriguez0Marilyn Velasco1Elena Corbalán Córdoba2Ana Paula Murray3INQUISUR-UNS, Instituto de Química del Sur, Departamento de Química, Universidad Nacional del Sur, Av. Alem 1253, Bahía Blanca B8000CPB, ArgentinaINQUISUR-UNS, Instituto de Química del Sur, Departamento de Química, Universidad Nacional del Sur, Av. Alem 1253, Bahía Blanca B8000CPB, ArgentinaINQUISUR-UNS, Instituto de Química del Sur, Departamento de Química, Universidad Nacional del Sur, Av. Alem 1253, Bahía Blanca B8000CPB, ArgentinaINQUISUR-UNS, Instituto de Química del Sur, Departamento de Química, Universidad Nacional del Sur, Av. Alem 1253, Bahía Blanca B8000CPB, Argentina<i>Grindelia ventanensis</i> (Asteraceae) is an endemic species growing wild in Argentina. In this work, we studied the dichloromethane extract of this plant for their antioxidant activity and cholinesterase inhibition. This extract was fractionated using column chromatography and HPLC. Six diterpenoids were isolated and identified using RMN and MS analyses. The 13-methyl-17-oxo-labda-7,13-diene-15-oic acid elicited the best results in both bioassays, with IC<sub>50</sub> = 11.04 µM in the AChE inhibition test and an antioxidant activity comparable to trolox, the reference antioxidant (IC<sub>50</sub> = 7.13 µM). Significant bioactivity was also observed for the rest of the isolated compounds.https://www.mdpi.com/2673-4583/12/1/71<i>Grindelia ventanensis</i>antioxidant activitycholinesterase inhibition |
| spellingShingle | Silvana Andrea Rodriguez Marilyn Velasco Elena Corbalán Córdoba Ana Paula Murray Bioactive Diterpenoids Obtained from <i>Grindelia ventanensis</i> Bartola & Tortosa (Asteraceae) Chemistry Proceedings <i>Grindelia ventanensis</i> antioxidant activity cholinesterase inhibition |
| title | Bioactive Diterpenoids Obtained from <i>Grindelia ventanensis</i> Bartola & Tortosa (Asteraceae) |
| title_full | Bioactive Diterpenoids Obtained from <i>Grindelia ventanensis</i> Bartola & Tortosa (Asteraceae) |
| title_fullStr | Bioactive Diterpenoids Obtained from <i>Grindelia ventanensis</i> Bartola & Tortosa (Asteraceae) |
| title_full_unstemmed | Bioactive Diterpenoids Obtained from <i>Grindelia ventanensis</i> Bartola & Tortosa (Asteraceae) |
| title_short | Bioactive Diterpenoids Obtained from <i>Grindelia ventanensis</i> Bartola & Tortosa (Asteraceae) |
| title_sort | bioactive diterpenoids obtained from i grindelia ventanensis i bartola tortosa asteraceae |
| topic | <i>Grindelia ventanensis</i> antioxidant activity cholinesterase inhibition |
| url | https://www.mdpi.com/2673-4583/12/1/71 |
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