Evaluation of the radical scavenging activity of a series of synthetic hydroxychalcones towards the DPPH radical
Sixteen hydroxychalcones were synthesized in sufficient purity by the Claisen–Schmidt condensation between appropriate acetophenones and aromatic aldehydes. All the compounds were evaluated for their ability to scavenge the stable free 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. Important structur...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2011-04-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.shd.org.rs/JSCS/Vol76/No4/02_4776_4135.pdf |
| _version_ | 1818754004921876480 |
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| author | STOYAN P. PARUSHEV BISTRA A. STAMBOLIYSKA DANIELA I. BATOVSKA IVA T. TODOROVA |
| author_facet | STOYAN P. PARUSHEV BISTRA A. STAMBOLIYSKA DANIELA I. BATOVSKA IVA T. TODOROVA |
| author_sort | STOYAN P. PARUSHEV |
| collection | DOAJ |
| description | Sixteen hydroxychalcones were synthesized in sufficient purity by the Claisen–Schmidt condensation between appropriate acetophenones and aromatic aldehydes. All the compounds were evaluated for their ability to scavenge the stable free 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. Important structure–activity relationships were observed that strongly contribute to the knowledge for the design of DPPH radical scavenging chalcones. Relevant theoretical parameters were computed in an attempt to understand and explain the obtained experimental results. |
| first_indexed | 2024-12-18T05:16:22Z |
| format | Article |
| id | doaj.art-20a7d7800d1d4faa964b02de56cdf792 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 |
| language | English |
| last_indexed | 2024-12-18T05:16:22Z |
| publishDate | 2011-04-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-20a7d7800d1d4faa964b02de56cdf7922022-12-21T21:19:45ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51392011-04-01764491497Evaluation of the radical scavenging activity of a series of synthetic hydroxychalcones towards the DPPH radicalSTOYAN P. PARUSHEVBISTRA A. STAMBOLIYSKADANIELA I. BATOVSKAIVA T. TODOROVASixteen hydroxychalcones were synthesized in sufficient purity by the Claisen–Schmidt condensation between appropriate acetophenones and aromatic aldehydes. All the compounds were evaluated for their ability to scavenge the stable free 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. Important structure–activity relationships were observed that strongly contribute to the knowledge for the design of DPPH radical scavenging chalcones. Relevant theoretical parameters were computed in an attempt to understand and explain the obtained experimental results.http://www.shd.org.rs/JSCS/Vol76/No4/02_4776_4135.pdfhydroxychalcones4’-chlorohydroxychalconessynthesisradical-scavenging activityDPPH free radical |
| spellingShingle | STOYAN P. PARUSHEV BISTRA A. STAMBOLIYSKA DANIELA I. BATOVSKA IVA T. TODOROVA Evaluation of the radical scavenging activity of a series of synthetic hydroxychalcones towards the DPPH radical Journal of the Serbian Chemical Society hydroxychalcones 4’-chlorohydroxychalcones synthesis radical-scavenging activity DPPH free radical |
| title | Evaluation of the radical scavenging activity of a series of synthetic hydroxychalcones towards the DPPH radical |
| title_full | Evaluation of the radical scavenging activity of a series of synthetic hydroxychalcones towards the DPPH radical |
| title_fullStr | Evaluation of the radical scavenging activity of a series of synthetic hydroxychalcones towards the DPPH radical |
| title_full_unstemmed | Evaluation of the radical scavenging activity of a series of synthetic hydroxychalcones towards the DPPH radical |
| title_short | Evaluation of the radical scavenging activity of a series of synthetic hydroxychalcones towards the DPPH radical |
| title_sort | evaluation of the radical scavenging activity of a series of synthetic hydroxychalcones towards the dpph radical |
| topic | hydroxychalcones 4’-chlorohydroxychalcones synthesis radical-scavenging activity DPPH free radical |
| url | http://www.shd.org.rs/JSCS/Vol76/No4/02_4776_4135.pdf |
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