Neurodegenerative Interplay of Cardiovascular Autonomic Dysregulation and the Retina in Early Multiple Sclerosis
Introduction: Autonomic nervous system (ANS) symptoms are prevalent in multiple sclerosis (MS) as is neurodegeneration. Our aim was to explore the occurrence of ANS symptoms and retinal neurodegeneration in a newly diagnosed MS population with tools available in a clinical setting.Methods: Forty-thr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.00507/full |
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| author | Sigrid A. de Rodez Benavent Sigrid A. de Rodez Benavent Gro O. Nygaard Kristian B. Nilsen Kristian B. Nilsen Lars Etholm Piotr Sowa Marte Wendel-Haga Marte Wendel-Haga Hanne F. Harbo Hanne F. Harbo Liv Drolsum Liv Drolsum Bruno Laeng Emilia Kerty Emilia Kerty Elisabeth G. Celius Elisabeth G. Celius |
| author_facet | Sigrid A. de Rodez Benavent Sigrid A. de Rodez Benavent Gro O. Nygaard Kristian B. Nilsen Kristian B. Nilsen Lars Etholm Piotr Sowa Marte Wendel-Haga Marte Wendel-Haga Hanne F. Harbo Hanne F. Harbo Liv Drolsum Liv Drolsum Bruno Laeng Emilia Kerty Emilia Kerty Elisabeth G. Celius Elisabeth G. Celius |
| author_sort | Sigrid A. de Rodez Benavent |
| collection | DOAJ |
| description | Introduction: Autonomic nervous system (ANS) symptoms are prevalent in multiple sclerosis (MS) as is neurodegeneration. Our aim was to explore the occurrence of ANS symptoms and retinal neurodegeneration in a newly diagnosed MS population with tools available in a clinical setting.Methods: Forty-three MS patients and 44 healthy controls took part in the study. We employed a bedside cardiovascular ANS test battery together with classical pupillometry, optical coherence tomography (OCT) evaluation of retinal neurodegeneration in eyes without previous optic neuritis (MSNON) and patients' self-report forms on fatigue, orthostatic and ANS symptoms.Results: Half of the patients presented with ANS symptoms and a high level of fatigue. There was a significant difference in ganglion cell layer thickness (mean GCIPL) evaluated by OCT in MSNON compared to healthy control eyes. We found a negative linearity of mean GCIPL on group level with increasing disease duration. Three patients fulfilled the criteria of postural orthostatic tachycardia syndrome (POTS).Conclusion: Our results demonstrate retinal neurodegeneration in MSNON, a high frequency of fatigue and a high prevalence of ANS symptoms in newly diagnosed patients. Whether neurodegeneration precedes ANS dysfunction or vice versa is still open to debate, but as unveiled by the presence of POTS in this MS population, differences in stress-response regulation add to the understanding of variation in onset-time of ANS dysfunction in early MS. |
| first_indexed | 2024-12-11T19:49:03Z |
| format | Article |
| id | doaj.art-20a93dce6fd84226991f5cd1c115863a |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-11T19:49:03Z |
| publishDate | 2019-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-20a93dce6fd84226991f5cd1c115863a2022-12-22T00:52:48ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-05-011010.3389/fneur.2019.00507449753Neurodegenerative Interplay of Cardiovascular Autonomic Dysregulation and the Retina in Early Multiple SclerosisSigrid A. de Rodez Benavent0Sigrid A. de Rodez Benavent1Gro O. Nygaard2Kristian B. Nilsen3Kristian B. Nilsen4Lars Etholm5Piotr Sowa6Marte Wendel-Haga7Marte Wendel-Haga8Hanne F. Harbo9Hanne F. Harbo10Liv Drolsum11Liv Drolsum12Bruno Laeng13Emilia Kerty14Emilia Kerty15Elisabeth G. Celius16Elisabeth G. Celius17Department of Ophthalmology, Oslo University Hospital, Oslo, NorwayFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, NorwayDepartment of Neurology, Oslo University Hospital, Oslo, NorwaySection for Clinical Neurophysiology, Department of Neurology, Oslo University Hospital, Oslo, NorwayDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, NorwaySection for Clinical Neurophysiology, Department of Neurology, Oslo University Hospital, Oslo, NorwayDivision of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, NorwayDepartment of Neurology, Oslo University Hospital, Oslo, NorwayDepartment of Neurology, Telemark Hospital, Skien, NorwayFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, NorwayDepartment of Neurology, Oslo University Hospital, Oslo, NorwayDepartment of Ophthalmology, Oslo University Hospital, Oslo, NorwayFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, NorwayDepartment of Psychology, University of Oslo, Oslo, NorwayFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, NorwayDepartment of Neurology, Oslo University Hospital, Oslo, NorwayFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, NorwayDepartment of Neurology, Oslo University Hospital, Oslo, NorwayIntroduction: Autonomic nervous system (ANS) symptoms are prevalent in multiple sclerosis (MS) as is neurodegeneration. Our aim was to explore the occurrence of ANS symptoms and retinal neurodegeneration in a newly diagnosed MS population with tools available in a clinical setting.Methods: Forty-three MS patients and 44 healthy controls took part in the study. We employed a bedside cardiovascular ANS test battery together with classical pupillometry, optical coherence tomography (OCT) evaluation of retinal neurodegeneration in eyes without previous optic neuritis (MSNON) and patients' self-report forms on fatigue, orthostatic and ANS symptoms.Results: Half of the patients presented with ANS symptoms and a high level of fatigue. There was a significant difference in ganglion cell layer thickness (mean GCIPL) evaluated by OCT in MSNON compared to healthy control eyes. We found a negative linearity of mean GCIPL on group level with increasing disease duration. Three patients fulfilled the criteria of postural orthostatic tachycardia syndrome (POTS).Conclusion: Our results demonstrate retinal neurodegeneration in MSNON, a high frequency of fatigue and a high prevalence of ANS symptoms in newly diagnosed patients. Whether neurodegeneration precedes ANS dysfunction or vice versa is still open to debate, but as unveiled by the presence of POTS in this MS population, differences in stress-response regulation add to the understanding of variation in onset-time of ANS dysfunction in early MS.https://www.frontiersin.org/article/10.3389/fneur.2019.00507/fullmultiple sclerosisneurodegenerationautonomic nervous systemoptical coherence tomographypupillometryfatigue |
| spellingShingle | Sigrid A. de Rodez Benavent Sigrid A. de Rodez Benavent Gro O. Nygaard Kristian B. Nilsen Kristian B. Nilsen Lars Etholm Piotr Sowa Marte Wendel-Haga Marte Wendel-Haga Hanne F. Harbo Hanne F. Harbo Liv Drolsum Liv Drolsum Bruno Laeng Emilia Kerty Emilia Kerty Elisabeth G. Celius Elisabeth G. Celius Neurodegenerative Interplay of Cardiovascular Autonomic Dysregulation and the Retina in Early Multiple Sclerosis Frontiers in Neurology multiple sclerosis neurodegeneration autonomic nervous system optical coherence tomography pupillometry fatigue |
| title | Neurodegenerative Interplay of Cardiovascular Autonomic Dysregulation and the Retina in Early Multiple Sclerosis |
| title_full | Neurodegenerative Interplay of Cardiovascular Autonomic Dysregulation and the Retina in Early Multiple Sclerosis |
| title_fullStr | Neurodegenerative Interplay of Cardiovascular Autonomic Dysregulation and the Retina in Early Multiple Sclerosis |
| title_full_unstemmed | Neurodegenerative Interplay of Cardiovascular Autonomic Dysregulation and the Retina in Early Multiple Sclerosis |
| title_short | Neurodegenerative Interplay of Cardiovascular Autonomic Dysregulation and the Retina in Early Multiple Sclerosis |
| title_sort | neurodegenerative interplay of cardiovascular autonomic dysregulation and the retina in early multiple sclerosis |
| topic | multiple sclerosis neurodegeneration autonomic nervous system optical coherence tomography pupillometry fatigue |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.00507/full |
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