Spontaneous tumor regression following COVID-19 vaccination
Vaccination against COVID-19 is critical for immuno-compromised individuals, including patients with cancer. Systemic reactogenicity, a manifestation of the innate immune response to vaccines, occurs in up to 69% of patients following vaccination with RNA-based COVID-19 vaccines. Tumor regression ca...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-03-01
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| Series: | Journal for ImmunoTherapy of Cancer |
| Online Access: | https://jitc.bmj.com/content/10/3/e004371.full |
| _version_ | 1826840844310675456 |
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| author | Hui Dai Renata Ferrarotto Myrna Godoy Diana Bell Shiaw-Yih Lin Daniel J McGrail Luana Guimaraes de Sousa Kaiyi Li Mario L Marques-Piubelli Cipriano Gonzalez Sammy Ferri-Borgogno Jared Burks |
| author_facet | Hui Dai Renata Ferrarotto Myrna Godoy Diana Bell Shiaw-Yih Lin Daniel J McGrail Luana Guimaraes de Sousa Kaiyi Li Mario L Marques-Piubelli Cipriano Gonzalez Sammy Ferri-Borgogno Jared Burks |
| author_sort | Hui Dai |
| collection | DOAJ |
| description | Vaccination against COVID-19 is critical for immuno-compromised individuals, including patients with cancer. Systemic reactogenicity, a manifestation of the innate immune response to vaccines, occurs in up to 69% of patients following vaccination with RNA-based COVID-19 vaccines. Tumor regression can occur following an intense immune-inflammatory response and novel strategies to treat cancer rely on manipulating the host immune system. Here, we report spontaneous regression of metastatic salivary gland myoepithelial carcinoma in a patient who experienced grade 3 systemic reactogenicity, following vaccination with the mRNA-1273 COVID-19 vaccine. Histological and immunophenotypic inspection of the postvaccination lung biopsy specimens showed a massive inflammatory infiltrate with scant embedded tumor clusters (<5%). Highly multiplexed imaging mass cytometry showed that the postvaccination lung metastasis samples had remarkable immune cell infiltration, including CD4+ T cells, CD8+ T cells, natural killer cells, B cells, and dendritic cells, which contrasted with very low levels of these cells in the prevaccination primary tumor and lung metastasis samples. CT scans obtained 3, 6, and 9 months after the second vaccine dose demonstrated persistent tumor shrinkage (50%, 67%, and 73% reduction, respectively), suggesting that vaccination stimulated anticancer immunity. Insight: This case suggests that the mRNA-1273 COVID-19 vaccine stimulated anticancer immunity and tumor regression. |
| first_indexed | 2024-03-12T21:41:10Z |
| format | Article |
| id | doaj.art-20a944e1411645f5a0c30f3c4c87870d |
| institution | Directory Open Access Journal |
| issn | 2051-1426 |
| language | English |
| last_indexed | 2025-02-16T12:48:58Z |
| publishDate | 2022-03-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Journal for ImmunoTherapy of Cancer |
| spelling | doaj.art-20a944e1411645f5a0c30f3c4c87870d2025-02-02T20:35:10ZengBMJ Publishing GroupJournal for ImmunoTherapy of Cancer2051-14262022-03-0110310.1136/jitc-2021-004371Spontaneous tumor regression following COVID-19 vaccinationHui Dai0Renata Ferrarotto1Myrna Godoy2Diana Bell3Shiaw-Yih Lin4Daniel J McGrail5Luana Guimaraes de Sousa6Kaiyi Li7Mario L Marques-Piubelli8Cipriano Gonzalez9Sammy Ferri-Borgogno10Jared Burks11Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA1The University of Texas MD Anderson Cancer Center, Houston, TX, USA4Department of Thoracic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USADepartment of Pathology, City of Hope National Medical Center, Duarte, California, USADepartment of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USACenter for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, Texas, USAThe University of Texas MD Anderson Cancer Center Department of Thoracic Head and Neck Medical Oncology, Houston, Texas, USAThoracic and Head and Neck, The University of Texas MD Anderson Cancer Center, Houston, Texas, USATranslational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USAThoracic and Head and Neck, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA2The University of Texas MD Anderson Cancer Center, Houston, TX, USALeukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USAVaccination against COVID-19 is critical for immuno-compromised individuals, including patients with cancer. Systemic reactogenicity, a manifestation of the innate immune response to vaccines, occurs in up to 69% of patients following vaccination with RNA-based COVID-19 vaccines. Tumor regression can occur following an intense immune-inflammatory response and novel strategies to treat cancer rely on manipulating the host immune system. Here, we report spontaneous regression of metastatic salivary gland myoepithelial carcinoma in a patient who experienced grade 3 systemic reactogenicity, following vaccination with the mRNA-1273 COVID-19 vaccine. Histological and immunophenotypic inspection of the postvaccination lung biopsy specimens showed a massive inflammatory infiltrate with scant embedded tumor clusters (<5%). Highly multiplexed imaging mass cytometry showed that the postvaccination lung metastasis samples had remarkable immune cell infiltration, including CD4+ T cells, CD8+ T cells, natural killer cells, B cells, and dendritic cells, which contrasted with very low levels of these cells in the prevaccination primary tumor and lung metastasis samples. CT scans obtained 3, 6, and 9 months after the second vaccine dose demonstrated persistent tumor shrinkage (50%, 67%, and 73% reduction, respectively), suggesting that vaccination stimulated anticancer immunity. Insight: This case suggests that the mRNA-1273 COVID-19 vaccine stimulated anticancer immunity and tumor regression.https://jitc.bmj.com/content/10/3/e004371.full |
| spellingShingle | Hui Dai Renata Ferrarotto Myrna Godoy Diana Bell Shiaw-Yih Lin Daniel J McGrail Luana Guimaraes de Sousa Kaiyi Li Mario L Marques-Piubelli Cipriano Gonzalez Sammy Ferri-Borgogno Jared Burks Spontaneous tumor regression following COVID-19 vaccination Journal for ImmunoTherapy of Cancer |
| title | Spontaneous tumor regression following COVID-19 vaccination |
| title_full | Spontaneous tumor regression following COVID-19 vaccination |
| title_fullStr | Spontaneous tumor regression following COVID-19 vaccination |
| title_full_unstemmed | Spontaneous tumor regression following COVID-19 vaccination |
| title_short | Spontaneous tumor regression following COVID-19 vaccination |
| title_sort | spontaneous tumor regression following covid 19 vaccination |
| url | https://jitc.bmj.com/content/10/3/e004371.full |
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