The Involvement of Polyamines Catabolism in the Crosstalk between Neurons and Astrocytes in Neurodegeneration

The Involvement of Polyamines Catabolism in the Crosstalk between Neurons and Astrocytes in Neurodegeneration

In mammalian cells, the content of polyamines is tightly regulated. Polyamines, including spermine, spermidine and putrescine, are involved in many cellular processes. Spermine oxidase specifically oxidizes spermine, and its deregulated activity has been reported to be linked to brain pathologies in...

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Bibliographic Details
Main Authors: Manuela Cervelli, Monica Averna, Laura Vergani, Marco Pedrazzi, Sarah Amato, Cristian Fiorucci, Marianna Nicoletta Rossi, Guido Maura, Paolo Mariottini, Chiara Cervetto, Manuela Marcoli
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomedicines
Subjects:
mouse genetic model
neuron damage
polyamine
reactive astrocytosis
spermine oxidase
Online Access:https://www.mdpi.com/2227-9059/10/7/1756

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