Neuropsychiatric events in an adult patient with influenza a (H3N2) treated with oseltamivir (Tamiflu): a case report

Abstract Background Total four influenza pandemics have happened since twentieth century, and currently influenza is in the seasonal epidemic around the world, with a sharp increase in its incidence each year. As an effective treatment of influenza infection, the use of oseltamivir is climbing globa...

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Main Authors: Ruochan Chen, Zhixiong Fang, Yan Huang
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Infectious Diseases
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12879-019-3827-4
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author Ruochan Chen
Zhixiong Fang
Yan Huang
author_facet Ruochan Chen
Zhixiong Fang
Yan Huang
author_sort Ruochan Chen
collection DOAJ
description Abstract Background Total four influenza pandemics have happened since twentieth century, and currently influenza is in the seasonal epidemic around the world, with a sharp increase in its incidence each year. As an effective treatment of influenza infection, the use of oseltamivir is climbing globally. However, there have been reports of neuropsychiatric events associated with the drug, mainly in young patients and males. To our knowledge, this is the first reported case of oseltamivir-associated neuropsychiatric events occurring in an patient over 50-year-old. Case presentation Here we present the case of a 57-year-old Chinese female with H3N2 influenza infection who developed abnormal psychiatric symptoms after administration of high doses of oseltamivir. The patient recovered completely within the cessation of oseltamivir. Conclusions We hope that our case report will lead clinicians to be mindful about oseltamivir’s potential neuropsychiatric side effects, and to pay special attention to each patient’s mental state, both in children and adults.
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spelling doaj.art-20abe61384374d77aead1249c1b4a6162022-12-21T18:18:33ZengBMCBMC Infectious Diseases1471-23342019-03-011911410.1186/s12879-019-3827-4Neuropsychiatric events in an adult patient with influenza a (H3N2) treated with oseltamivir (Tamiflu): a case reportRuochan Chen0Zhixiong Fang1Yan Huang2Department of Infectious Disease, Xiangya Hospital, Central South UniversityDepartment of Infectious Disease, Xiangtan Central HospitalDepartment of Infectious Disease, Xiangya Hospital, Central South UniversityAbstract Background Total four influenza pandemics have happened since twentieth century, and currently influenza is in the seasonal epidemic around the world, with a sharp increase in its incidence each year. As an effective treatment of influenza infection, the use of oseltamivir is climbing globally. However, there have been reports of neuropsychiatric events associated with the drug, mainly in young patients and males. To our knowledge, this is the first reported case of oseltamivir-associated neuropsychiatric events occurring in an patient over 50-year-old. Case presentation Here we present the case of a 57-year-old Chinese female with H3N2 influenza infection who developed abnormal psychiatric symptoms after administration of high doses of oseltamivir. The patient recovered completely within the cessation of oseltamivir. Conclusions We hope that our case report will lead clinicians to be mindful about oseltamivir’s potential neuropsychiatric side effects, and to pay special attention to each patient’s mental state, both in children and adults.http://link.springer.com/article/10.1186/s12879-019-3827-4OseltamivirNeuropsychiatric eventsSide effectsAdult
spellingShingle Ruochan Chen
Zhixiong Fang
Yan Huang
Neuropsychiatric events in an adult patient with influenza a (H3N2) treated with oseltamivir (Tamiflu): a case report
BMC Infectious Diseases
Oseltamivir
Neuropsychiatric events
Side effects
Adult
title Neuropsychiatric events in an adult patient with influenza a (H3N2) treated with oseltamivir (Tamiflu): a case report
title_full Neuropsychiatric events in an adult patient with influenza a (H3N2) treated with oseltamivir (Tamiflu): a case report
title_fullStr Neuropsychiatric events in an adult patient with influenza a (H3N2) treated with oseltamivir (Tamiflu): a case report
title_full_unstemmed Neuropsychiatric events in an adult patient with influenza a (H3N2) treated with oseltamivir (Tamiflu): a case report
title_short Neuropsychiatric events in an adult patient with influenza a (H3N2) treated with oseltamivir (Tamiflu): a case report
title_sort neuropsychiatric events in an adult patient with influenza a h3n2 treated with oseltamivir tamiflu a case report
topic Oseltamivir
Neuropsychiatric events
Side effects
Adult
url http://link.springer.com/article/10.1186/s12879-019-3827-4
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AT zhixiongfang neuropsychiatriceventsinanadultpatientwithinfluenzaah3n2treatedwithoseltamivirtamifluacasereport
AT yanhuang neuropsychiatriceventsinanadultpatientwithinfluenzaah3n2treatedwithoseltamivirtamifluacasereport