Experimental cholesteatoma: a comparison between spontaneous and induced models
Objective: To compare the incidence and the histopathological aspect of spontaneous and two induced Mongolian gerbils’ models of cholesteatoma: External Auditory Canal (EAC) obliteration model and the Auditory Tube (AT) cauterization model. Methods: Fifty-four ears of 27 animals were divided into EA...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Brazilian Journal of Otorhinolaryngology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1808869421001749 |
| _version_ | 1828057244252504064 |
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| author | Felipe da Costa Huve Jefferson André Bauer Fábio André Selaimen Maurício Noschang Lopes da Silva Sady Selaimen da Costa |
| author_facet | Felipe da Costa Huve Jefferson André Bauer Fábio André Selaimen Maurício Noschang Lopes da Silva Sady Selaimen da Costa |
| author_sort | Felipe da Costa Huve |
| collection | DOAJ |
| description | Objective: To compare the incidence and the histopathological aspect of spontaneous and two induced Mongolian gerbils’ models of cholesteatoma: External Auditory Canal (EAC) obliteration model and the Auditory Tube (AT) cauterization model. Methods: Fifty-four ears of 27 animals were divided into EAC obliteration, AT cauterization, and control groups and histologically assessed for cholesteatoma incidence and classification at intervals of 2, 4, 8, and 16 weeks. Results: Cholesteatoma was diagnosed in 30 of the 53 ears evaluated with a significantly higher incidence in groups that received some type of intervention (p < 0.0001). It was not possible to histologically distinguish cholesteatomas of the same stage between the study groups. Conclusion: Although we observed a significant increase in cholesteatoma incidence with the two methods used when compared to the control group, all developed cholesteatomas were apparently identical from a histological point of view. |
| first_indexed | 2024-04-10T21:09:32Z |
| format | Article |
| id | doaj.art-20ac2d31edf247ca88369eddbfeb3309 |
| institution | Directory Open Access Journal |
| issn | 1808-8694 |
| language | English |
| last_indexed | 2024-04-10T21:09:32Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Otorhinolaryngology |
| spelling | doaj.art-20ac2d31edf247ca88369eddbfeb33092023-01-21T04:20:34ZengElsevierBrazilian Journal of Otorhinolaryngology1808-86942023-01-018917378Experimental cholesteatoma: a comparison between spontaneous and induced modelsFelipe da Costa Huve0Jefferson André Bauer1Fábio André Selaimen2Maurício Noschang Lopes da Silva3Sady Selaimen da Costa4Hospital de Clínicas de Porto Alegre, Departamento de Otorrinolaringologia - Cirurgia de Cabeça e Pescoço, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Corresponding author at: Hospital de Clínicas de Porto Alegre, Departamento de Otorrinolaringologia - Cirurgia de Cabeça e Pescoço, Porto Alegre, RS, Brazil.Hospital de Clínicas de Porto Alegre, Departamento de Otorrinolaringologia - Cirurgia de Cabeça e Pescoço, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BrazilHospital de Clínicas de Porto Alegre, Departamento de Otorrinolaringologia - Cirurgia de Cabeça e Pescoço, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BrazilHospital de Clínicas de Porto Alegre, Departamento de Otorrinolaringologia - Cirurgia de Cabeça e Pescoço, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BrazilHospital de Clínicas de Porto Alegre, Departamento de Otorrinolaringologia - Cirurgia de Cabeça e Pescoço, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BrazilObjective: To compare the incidence and the histopathological aspect of spontaneous and two induced Mongolian gerbils’ models of cholesteatoma: External Auditory Canal (EAC) obliteration model and the Auditory Tube (AT) cauterization model. Methods: Fifty-four ears of 27 animals were divided into EAC obliteration, AT cauterization, and control groups and histologically assessed for cholesteatoma incidence and classification at intervals of 2, 4, 8, and 16 weeks. Results: Cholesteatoma was diagnosed in 30 of the 53 ears evaluated with a significantly higher incidence in groups that received some type of intervention (p < 0.0001). It was not possible to histologically distinguish cholesteatomas of the same stage between the study groups. Conclusion: Although we observed a significant increase in cholesteatoma incidence with the two methods used when compared to the control group, all developed cholesteatomas were apparently identical from a histological point of view.http://www.sciencedirect.com/science/article/pii/S1808869421001749CholesteatomaPathogenesisMongolian gerbilsExperimental models |
| spellingShingle | Felipe da Costa Huve Jefferson André Bauer Fábio André Selaimen Maurício Noschang Lopes da Silva Sady Selaimen da Costa Experimental cholesteatoma: a comparison between spontaneous and induced models Brazilian Journal of Otorhinolaryngology Cholesteatoma Pathogenesis Mongolian gerbils Experimental models |
| title | Experimental cholesteatoma: a comparison between spontaneous and induced models |
| title_full | Experimental cholesteatoma: a comparison between spontaneous and induced models |
| title_fullStr | Experimental cholesteatoma: a comparison between spontaneous and induced models |
| title_full_unstemmed | Experimental cholesteatoma: a comparison between spontaneous and induced models |
| title_short | Experimental cholesteatoma: a comparison between spontaneous and induced models |
| title_sort | experimental cholesteatoma a comparison between spontaneous and induced models |
| topic | Cholesteatoma Pathogenesis Mongolian gerbils Experimental models |
| url | http://www.sciencedirect.com/science/article/pii/S1808869421001749 |
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