ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

Heterozygous mutations in the glucocerebrosidase gene (GBA) represent the strongest common genetic risk factor for Parkinson's disease (PD), the second most common neurodegenerative disorder. However, the molecular mechanisms underlying this association are still poorly understood. Here, we hav...

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Bibliographic Details
Main Authors: Hugo J.R. Fernandes, Elizabeth M. Hartfield, Helen C. Christian, Evangelia Emmanoulidou, Ying Zheng, Heather Booth, Helle Bogetofte, Charmaine Lang, Brent J. Ryan, S. Pablo Sardi, Jennifer Badger, Jane Vowles, Samuel Evetts, George K. Tofaris, Kostas Vekrellis, Kevin Talbot, Michele T. Hu, William James, Sally A. Cowley, Richard Wade-Martins
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116000308

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http://www.sciencedirect.com/science/article/pii/S2213671116000308

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