Does Massive Bowel Resection in Newborns Affect Further Immunity in Children?
Background: The massive resection of the small intestine leading to short bowel syndrome (SBS) deprives an organism of many immunocompetent cells concentrated in gut-associated lymphoid tissue, the largest immune organ in humans. We have aimed to access the influence of bowel resection on adaptive i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/11/1/114 |
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| author | Katarzyna Sznurkowska Anna Borkowska Agnieszka Zagierska Magdalena Malanowska Maciej Zieliński Maciej Zagierski Piotr Trzonkowski Marcin Łosin Agnieszka Szlagatys-Sidorkiewicz |
| author_facet | Katarzyna Sznurkowska Anna Borkowska Agnieszka Zagierska Magdalena Malanowska Maciej Zieliński Maciej Zagierski Piotr Trzonkowski Marcin Łosin Agnieszka Szlagatys-Sidorkiewicz |
| author_sort | Katarzyna Sznurkowska |
| collection | DOAJ |
| description | Background: The massive resection of the small intestine leading to short bowel syndrome (SBS) deprives an organism of many immunocompetent cells concentrated in gut-associated lymphoid tissue, the largest immune organ in humans. We have aimed to access the influence of bowel resection on adaptive immunity in children, based on peripheral lymphocyte subsets and serum immunoglobulins. Methods: 15 children who underwent bowel resection in the first months of their life and required further home parenteral nutrition were enrolled into the study. Based on flow cytometry, the following subsets of lymphocytes were evaluated: T, B, NK, CD4+, C8+, and activated T cells. Results: Statistically significant differences were found for the rates of lymphocytes B, T, CD8+, and NK cells. The absolute count of NK cells was lower in the SBS group than in the control group. Absolute counts of lymphocytes, lymphocytes B, T, CD4+, and percentages of lymphocytes CD4+, and activated T cells inversely correlated with age in SBS group. Conclusions: Children with SBS do not present with clinical signs of immunodeficiency as well as deficits in peripheral lymphocyte subsets and serum immunoglobulins. The tendency of the lymphocyte subpopulations to decrease over time points out the necessity for longer follow- up. |
| first_indexed | 2024-03-08T11:00:50Z |
| format | Article |
| id | doaj.art-20ad24474a204690985d1526ad44954c |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-08T11:00:50Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-20ad24474a204690985d1526ad44954c2024-01-26T15:49:25ZengMDPI AGChildren2227-90672024-01-0111111410.3390/children11010114Does Massive Bowel Resection in Newborns Affect Further Immunity in Children?Katarzyna Sznurkowska0Anna Borkowska1Agnieszka Zagierska2Magdalena Malanowska3Maciej Zieliński4Maciej Zagierski5Piotr Trzonkowski6Marcin Łosin7Agnieszka Szlagatys-Sidorkiewicz8Department of Paediatrics, Pediatric Gastroenterology, Allergology and Nutrition, Medical University of Gdańsk, Nowe Ogrody 1-6, 80-803 Gdańsk, PolandDepartment of Paediatrics, Pediatric Gastroenterology, Allergology and Nutrition, Medical University of Gdańsk, Nowe Ogrody 1-6, 80-803 Gdańsk, PolandDepartment of Paediatrics, Pediatric Gastroenterology, Allergology and Nutrition, Medical University of Gdańsk, Nowe Ogrody 1-6, 80-803 Gdańsk, PolandDepartment of Paediatrics, Hematology and Oncology, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, PolandDepartment of Medical Immunology, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, PolandDepartment of Paediatrics, Pediatric Gastroenterology, Allergology and Nutrition, Medical University of Gdańsk, Nowe Ogrody 1-6, 80-803 Gdańsk, PolandDepartment of Medical Immunology, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, PolandDepartment of Surgery and Urology for Children and Adolescents, Medical University of Gdansk, Dębinki 7, 80-211 Gdańsk, PolandDepartment of Paediatrics, Pediatric Gastroenterology, Allergology and Nutrition, Medical University of Gdańsk, Nowe Ogrody 1-6, 80-803 Gdańsk, PolandBackground: The massive resection of the small intestine leading to short bowel syndrome (SBS) deprives an organism of many immunocompetent cells concentrated in gut-associated lymphoid tissue, the largest immune organ in humans. We have aimed to access the influence of bowel resection on adaptive immunity in children, based on peripheral lymphocyte subsets and serum immunoglobulins. Methods: 15 children who underwent bowel resection in the first months of their life and required further home parenteral nutrition were enrolled into the study. Based on flow cytometry, the following subsets of lymphocytes were evaluated: T, B, NK, CD4+, C8+, and activated T cells. Results: Statistically significant differences were found for the rates of lymphocytes B, T, CD8+, and NK cells. The absolute count of NK cells was lower in the SBS group than in the control group. Absolute counts of lymphocytes, lymphocytes B, T, CD4+, and percentages of lymphocytes CD4+, and activated T cells inversely correlated with age in SBS group. Conclusions: Children with SBS do not present with clinical signs of immunodeficiency as well as deficits in peripheral lymphocyte subsets and serum immunoglobulins. The tendency of the lymphocyte subpopulations to decrease over time points out the necessity for longer follow- up.https://www.mdpi.com/2227-9067/11/1/114short bowel syndromelymphocyte subsetsimmunoglobulinschildren |
| spellingShingle | Katarzyna Sznurkowska Anna Borkowska Agnieszka Zagierska Magdalena Malanowska Maciej Zieliński Maciej Zagierski Piotr Trzonkowski Marcin Łosin Agnieszka Szlagatys-Sidorkiewicz Does Massive Bowel Resection in Newborns Affect Further Immunity in Children? Children short bowel syndrome lymphocyte subsets immunoglobulins children |
| title | Does Massive Bowel Resection in Newborns Affect Further Immunity in Children? |
| title_full | Does Massive Bowel Resection in Newborns Affect Further Immunity in Children? |
| title_fullStr | Does Massive Bowel Resection in Newborns Affect Further Immunity in Children? |
| title_full_unstemmed | Does Massive Bowel Resection in Newborns Affect Further Immunity in Children? |
| title_short | Does Massive Bowel Resection in Newborns Affect Further Immunity in Children? |
| title_sort | does massive bowel resection in newborns affect further immunity in children |
| topic | short bowel syndrome lymphocyte subsets immunoglobulins children |
| url | https://www.mdpi.com/2227-9067/11/1/114 |
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