Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT
Tobramycin is a potent antimicrobial aminoglycoside and its effective delivery by encapsulation within nanoparticle carriers could increase its activity against infections through a combination of sustained release and enhanced uptake. Effective antimicrobial therapy against a clinically relevant mo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-06-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/10/2/26 |
| _version_ | 1828109527527981056 |
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| author | Marcus Hill Richard N. Cunningham Rania M. Hathout Christopher Johnston John G. Hardy Marie E. Migaud |
| author_facet | Marcus Hill Richard N. Cunningham Rania M. Hathout Christopher Johnston John G. Hardy Marie E. Migaud |
| author_sort | Marcus Hill |
| collection | DOAJ |
| description | Tobramycin is a potent antimicrobial aminoglycoside and its effective delivery by encapsulation within nanoparticle carriers could increase its activity against infections through a combination of sustained release and enhanced uptake. Effective antimicrobial therapy against a clinically relevant model bacteria (<i>Pseudomonas aeruginosa</i>) requires sufficient levels of therapeutic drug to maintain a drug concentration above the microbial inhibitory concentration (MIC) of the bacteria. Previous studies have shown that loading of aminoglycoside drugs in poly(lactic-co-glycolic) acid (PLGA)-based delivery systems is generally poor due to weak interactions between the drug and the polymer. The formation of complexes of tobramycin with dioctylsulfosuccinate (AOT) allows the effective loading of the drug in PLGA-nanoparticles and such nanoparticles can effectively deliver the antimicrobial aminoglycoside with retention of tobramycin antibacterial function. |
| first_indexed | 2024-04-11T11:04:52Z |
| format | Article |
| id | doaj.art-20ad67632b364dfdac591ae33b93054e |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-04-11T11:04:52Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-20ad67632b364dfdac591ae33b93054e2022-12-22T04:28:24ZengMDPI AGJournal of Functional Biomaterials2079-49832019-06-011022610.3390/jfb10020026jfb10020026Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOTMarcus Hill0Richard N. Cunningham1Rania M. Hathout2Christopher Johnston3John G. Hardy4Marie E. Migaud5School of Pharmacy, Queen’s University Belfast, Belfast BT7 1NN, UKSchool of Pharmacy, Queen’s University Belfast, Belfast BT7 1NN, UKDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, EgyptSchool of Pharmacy, Queen’s University Belfast, Belfast BT7 1NN, UKDepartment of Chemistry, Lancaster University, Lancaster, Lancashire LA1 4YB, UKSchool of Pharmacy, Queen’s University Belfast, Belfast BT7 1NN, UKTobramycin is a potent antimicrobial aminoglycoside and its effective delivery by encapsulation within nanoparticle carriers could increase its activity against infections through a combination of sustained release and enhanced uptake. Effective antimicrobial therapy against a clinically relevant model bacteria (<i>Pseudomonas aeruginosa</i>) requires sufficient levels of therapeutic drug to maintain a drug concentration above the microbial inhibitory concentration (MIC) of the bacteria. Previous studies have shown that loading of aminoglycoside drugs in poly(lactic-co-glycolic) acid (PLGA)-based delivery systems is generally poor due to weak interactions between the drug and the polymer. The formation of complexes of tobramycin with dioctylsulfosuccinate (AOT) allows the effective loading of the drug in PLGA-nanoparticles and such nanoparticles can effectively deliver the antimicrobial aminoglycoside with retention of tobramycin antibacterial function.https://www.mdpi.com/2079-4983/10/2/26biomedical applicationscolloidsdrug delivery systemsnanoparticlesantimicrobial |
| spellingShingle | Marcus Hill Richard N. Cunningham Rania M. Hathout Christopher Johnston John G. Hardy Marie E. Migaud Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT Journal of Functional Biomaterials biomedical applications colloids drug delivery systems nanoparticles antimicrobial |
| title | Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT |
| title_full | Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT |
| title_fullStr | Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT |
| title_full_unstemmed | Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT |
| title_short | Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT |
| title_sort | formulation of antimicrobial tobramycin loaded plga nanoparticles via complexation with aot |
| topic | biomedical applications colloids drug delivery systems nanoparticles antimicrobial |
| url | https://www.mdpi.com/2079-4983/10/2/26 |
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