Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome

Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome

Summary: Expansion of the hexanucleotide repeat GGGGCC in the C9orf72 gene is the most common genetic factor in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Poly-Gly-Ala (poly-GA), one form of dipeptide repeat proteins (DPRs) produced from GGGGCC repeats, tends to form neur...

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Bibliographic Details
Main Authors: Xiaoqiu Shu, Chen Wei, Wen-Yo Tu, Keke Zhong, Shuyuan Qi, Ailian Wang, Lei Bai, Shan-Xin Zhang, Benyan Luo, Zhen-Zhong Xu, Kejing Zhang, Chengyong Shen
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723001444

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http://www.sciencedirect.com/science/article/pii/S2211124723001444

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