Recent progress of JAK inhibitors for hematological disorders
AbstractJAK inhibitors are important therapeutic options for hematological disorders, especially myeloproliferative neoplasms. Ruxolitinib, the first JAK inhibitor approved for clinical use, improves splenomegaly and ameliorates constitutional symptoms in both myelofibrosis and polycythemia vera pat...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-07-01
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| Series: | Immunological Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/25785826.2022.2139317 |
| _version_ | 1797767312274620416 |
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| author | Keita Kirito |
| author_facet | Keita Kirito |
| author_sort | Keita Kirito |
| collection | DOAJ |
| description | AbstractJAK inhibitors are important therapeutic options for hematological disorders, especially myeloproliferative neoplasms. Ruxolitinib, the first JAK inhibitor approved for clinical use, improves splenomegaly and ameliorates constitutional symptoms in both myelofibrosis and polycythemia vera patients. Ruxolitinib is also useful for controlling hematocrit levels in polycythemia vera patients who were inadequately controlled by conventional therapies. Furthermore, pretransplantation use of ruxolitinib may improve the outcome of allo-hematopoietic stem cell transplantation in myelofibrosis. In contrast to these clinical merits, evidence of the disease-modifying action of ruxolitinib, i.e., reduction of malignant clones or improvement of bone marrow pathological findings, is limited, and many myelofibrosis patients discontinued ruxolitinib due to adverse events or disease progression. To overcome these limitations of ruxolitinib, several new types of JAK inhibitors have been developed. Among them, fedratinib was proven to provide clinical merits even in patients who were resistant or intolerant to ruxolitinib. Pacritinib and momelotinib have shown merits for myelofibrosis patients with thrombocytopenia or anemia, respectively. In addition to treatment for myeloproliferative neoplasms, recent studies have demonstrated that JAK inhibitors are novel and attractive therapeutic options for corticosteroid-refractory acute as well as chronic graft versus host disease. |
| first_indexed | 2024-03-12T20:37:52Z |
| format | Article |
| id | doaj.art-20aea60545ba48ff8c19cfdc13e9193d |
| institution | Directory Open Access Journal |
| issn | 2578-5826 |
| language | English |
| last_indexed | 2024-03-12T20:37:52Z |
| publishDate | 2023-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Immunological Medicine |
| spelling | doaj.art-20aea60545ba48ff8c19cfdc13e9193d2023-08-01T12:02:17ZengTaylor & Francis GroupImmunological Medicine2578-58262023-07-0146313114210.1080/25785826.2022.2139317Recent progress of JAK inhibitors for hematological disordersKeita Kirito0Department of Hematology and Oncology, University of Yamanashi, Yamanashi, JapanAbstractJAK inhibitors are important therapeutic options for hematological disorders, especially myeloproliferative neoplasms. Ruxolitinib, the first JAK inhibitor approved for clinical use, improves splenomegaly and ameliorates constitutional symptoms in both myelofibrosis and polycythemia vera patients. Ruxolitinib is also useful for controlling hematocrit levels in polycythemia vera patients who were inadequately controlled by conventional therapies. Furthermore, pretransplantation use of ruxolitinib may improve the outcome of allo-hematopoietic stem cell transplantation in myelofibrosis. In contrast to these clinical merits, evidence of the disease-modifying action of ruxolitinib, i.e., reduction of malignant clones or improvement of bone marrow pathological findings, is limited, and many myelofibrosis patients discontinued ruxolitinib due to adverse events or disease progression. To overcome these limitations of ruxolitinib, several new types of JAK inhibitors have been developed. Among them, fedratinib was proven to provide clinical merits even in patients who were resistant or intolerant to ruxolitinib. Pacritinib and momelotinib have shown merits for myelofibrosis patients with thrombocytopenia or anemia, respectively. In addition to treatment for myeloproliferative neoplasms, recent studies have demonstrated that JAK inhibitors are novel and attractive therapeutic options for corticosteroid-refractory acute as well as chronic graft versus host disease.https://www.tandfonline.com/doi/10.1080/25785826.2022.2139317JAK inhibitormyeloproliferative neoplasmsmyelofibrosisruxolitinibGVHD |
| spellingShingle | Keita Kirito Recent progress of JAK inhibitors for hematological disorders Immunological Medicine JAK inhibitor myeloproliferative neoplasms myelofibrosis ruxolitinib GVHD |
| title | Recent progress of JAK inhibitors for hematological disorders |
| title_full | Recent progress of JAK inhibitors for hematological disorders |
| title_fullStr | Recent progress of JAK inhibitors for hematological disorders |
| title_full_unstemmed | Recent progress of JAK inhibitors for hematological disorders |
| title_short | Recent progress of JAK inhibitors for hematological disorders |
| title_sort | recent progress of jak inhibitors for hematological disorders |
| topic | JAK inhibitor myeloproliferative neoplasms myelofibrosis ruxolitinib GVHD |
| url | https://www.tandfonline.com/doi/10.1080/25785826.2022.2139317 |
| work_keys_str_mv | AT keitakirito recentprogressofjakinhibitorsforhematologicaldisorders |