Effect of Foot-and-Mouth Disease Vaccine on Pregnancy Failure in Beef Cows
This study evaluates whether the foot-and-mouth disease (FMD) vaccination increases pregnancy failures in Bos taurus beef cows. A total of 3,379 cows were assigned to two experimental groups to receive (n = 1,722) or not receive (n = 1,657) a FMD vaccine (commercial preparation containing FMD virus,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2021.761304/full |
| _version_ | 1818403186341314560 |
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| author | Camila Garcia-Pintos Camila Garcia-Pintos Franklin Riet-Correa Franklin Riet-Correa Alejo Menchaca Alejo Menchaca |
| author_facet | Camila Garcia-Pintos Camila Garcia-Pintos Franklin Riet-Correa Franklin Riet-Correa Alejo Menchaca Alejo Menchaca |
| author_sort | Camila Garcia-Pintos |
| collection | DOAJ |
| description | This study evaluates whether the foot-and-mouth disease (FMD) vaccination increases pregnancy failures in Bos taurus beef cows. A total of 3,379 cows were assigned to two experimental groups to receive (n = 1,722) or not receive (n = 1,657) a FMD vaccine (commercial preparation containing FMD virus, O1 Campos and A24 Cruzeiro) at different gestational age. Pregnancy diagnosis was performed by ultrasonography at vaccination time (Day 0), and the cows were classified by days of pregnancy as follows: (a) <29 days after mating (presumed pregnant cows, n = 778), (b) between 30 and 44 days of pregnancy (n = 1,100), (c) 45 and 59 days of pregnancy (n = 553), and (d) between 60 and 90 days of pregnancy (n = 948). Pregnancy failure was determined 30 days after vaccination by a second ultrasound examination. Cows that were vaccinated within 29 days after mating had a 7.8% greater pregnancy failure rate than non-vaccinated cows (44.1%, 163/370 vs. 36.3%, 148/408, respectively; P <0.05). Cows vaccinated between 30 and 44 days of gestation had a pregnancy failure rate greater than non-vaccinated cows (4.9%, 28/576 vs. 2.5%, 13/524, respectively; P <0.05). When cows received the vaccine between days 45 and 90 of gestation no differences in pregnancy failure were observed (0.8%, 6/776 vs. 1.2%, 9/725, respectively; P = NS). Body temperature and local adverse reactions to vaccine inoculation were recorded in a subset of 152 multiparous cows. Hyperthermia (>39.5°C) was detected on Day 1 or 2 in 28.0% (21/75) of vaccinated vs. 7.8% (6/77) of non-vaccinated cows (P <0.01). Local adverse reaction to the FMD vaccine inoculation increased from 0.0% (0/75) on Day 0, to 15.7% (11/75) on Day 4, and 38.7% (29/75) on Day 10 (P <0.01). On Day 30 local reaction was detected in 10.5% (34/323) and fell to 2.2% on Day 60 (7/323) post vaccination (P <0.01). In conclusion, FMD vaccine increases pregnancy failure when it is administered before 45 days of gestation, an effect that was associated with hyperthermia and local adverse reaction. No effect on pregnancy failure was found when vaccination was performed after 45 days of gestation. |
| first_indexed | 2024-12-14T08:20:15Z |
| format | Article |
| id | doaj.art-20aebe4cfd8f4ecd90470f590e47f292 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-12-14T08:20:15Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Veterinary Science |
| spelling | doaj.art-20aebe4cfd8f4ecd90470f590e47f2922022-12-21T23:09:49ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692021-11-01810.3389/fvets.2021.761304761304Effect of Foot-and-Mouth Disease Vaccine on Pregnancy Failure in Beef CowsCamila Garcia-Pintos0Camila Garcia-Pintos1Franklin Riet-Correa2Franklin Riet-Correa3Alejo Menchaca4Alejo Menchaca5Instituto de Reproducción Animal Uruguay, Fundación IRAUy, Montevideo, UruguayPlataforma de Salud Animal, Instituto Nacional de Investigación Agropecuaria, Montevideo, UruguayPlataforma de Salud Animal, Instituto Nacional de Investigación Agropecuaria, Montevideo, UruguayPrograma de Pós-graduação em Ciência Animal nos Trópicos, Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia, Salvador, BrazilInstituto de Reproducción Animal Uruguay, Fundación IRAUy, Montevideo, UruguayPlataforma de Salud Animal, Instituto Nacional de Investigación Agropecuaria, Montevideo, UruguayThis study evaluates whether the foot-and-mouth disease (FMD) vaccination increases pregnancy failures in Bos taurus beef cows. A total of 3,379 cows were assigned to two experimental groups to receive (n = 1,722) or not receive (n = 1,657) a FMD vaccine (commercial preparation containing FMD virus, O1 Campos and A24 Cruzeiro) at different gestational age. Pregnancy diagnosis was performed by ultrasonography at vaccination time (Day 0), and the cows were classified by days of pregnancy as follows: (a) <29 days after mating (presumed pregnant cows, n = 778), (b) between 30 and 44 days of pregnancy (n = 1,100), (c) 45 and 59 days of pregnancy (n = 553), and (d) between 60 and 90 days of pregnancy (n = 948). Pregnancy failure was determined 30 days after vaccination by a second ultrasound examination. Cows that were vaccinated within 29 days after mating had a 7.8% greater pregnancy failure rate than non-vaccinated cows (44.1%, 163/370 vs. 36.3%, 148/408, respectively; P <0.05). Cows vaccinated between 30 and 44 days of gestation had a pregnancy failure rate greater than non-vaccinated cows (4.9%, 28/576 vs. 2.5%, 13/524, respectively; P <0.05). When cows received the vaccine between days 45 and 90 of gestation no differences in pregnancy failure were observed (0.8%, 6/776 vs. 1.2%, 9/725, respectively; P = NS). Body temperature and local adverse reactions to vaccine inoculation were recorded in a subset of 152 multiparous cows. Hyperthermia (>39.5°C) was detected on Day 1 or 2 in 28.0% (21/75) of vaccinated vs. 7.8% (6/77) of non-vaccinated cows (P <0.01). Local adverse reaction to the FMD vaccine inoculation increased from 0.0% (0/75) on Day 0, to 15.7% (11/75) on Day 4, and 38.7% (29/75) on Day 10 (P <0.01). On Day 30 local reaction was detected in 10.5% (34/323) and fell to 2.2% on Day 60 (7/323) post vaccination (P <0.01). In conclusion, FMD vaccine increases pregnancy failure when it is administered before 45 days of gestation, an effect that was associated with hyperthermia and local adverse reaction. No effect on pregnancy failure was found when vaccination was performed after 45 days of gestation.https://www.frontiersin.org/articles/10.3389/fvets.2021.761304/fullgestation maintenancepregnancy lossesembryo mortalityabortionFMD vaccinehyperthermia |
| spellingShingle | Camila Garcia-Pintos Camila Garcia-Pintos Franklin Riet-Correa Franklin Riet-Correa Alejo Menchaca Alejo Menchaca Effect of Foot-and-Mouth Disease Vaccine on Pregnancy Failure in Beef Cows Frontiers in Veterinary Science gestation maintenance pregnancy losses embryo mortality abortion FMD vaccine hyperthermia |
| title | Effect of Foot-and-Mouth Disease Vaccine on Pregnancy Failure in Beef Cows |
| title_full | Effect of Foot-and-Mouth Disease Vaccine on Pregnancy Failure in Beef Cows |
| title_fullStr | Effect of Foot-and-Mouth Disease Vaccine on Pregnancy Failure in Beef Cows |
| title_full_unstemmed | Effect of Foot-and-Mouth Disease Vaccine on Pregnancy Failure in Beef Cows |
| title_short | Effect of Foot-and-Mouth Disease Vaccine on Pregnancy Failure in Beef Cows |
| title_sort | effect of foot and mouth disease vaccine on pregnancy failure in beef cows |
| topic | gestation maintenance pregnancy losses embryo mortality abortion FMD vaccine hyperthermia |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2021.761304/full |
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