Where are we today with Helicobacter pylori infection among healthy children in Saudi Arabia?
Background/Aims: The available studies on Helicobacter pylori (H. pylori) prevalence among healthy asymptomatic population across Saudi Arabia suffers from significant limitations. We conducted this large population-based study to estimate the H. pylori seropositivity rate among apparently healthy c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | The Saudi Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2019;volume=25;issue=5;spage=309;epage=318;aulast=Al-Hussaini |
| _version_ | 1828400857959366656 |
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| author | Abdulrahman A Al-Hussaini Abdullah N Al Jurayyan Salman M Bashir Dayel Alshahrani |
| author_facet | Abdulrahman A Al-Hussaini Abdullah N Al Jurayyan Salman M Bashir Dayel Alshahrani |
| author_sort | Abdulrahman A Al-Hussaini |
| collection | DOAJ |
| description | Background/Aims: The available studies on Helicobacter pylori (H. pylori) prevalence among healthy asymptomatic population across Saudi Arabia suffers from significant limitations. We conducted this large population-based study to estimate the H. pylori seropositivity rate among apparently healthy children in Saudi Arabia, using anti-H. pylori immunoglobulin A (IgA) and IgG serology tests, and to study the influence of H. pylori infection on growth.
Materials and Methods: We conducted a cross-sectional study to screen apparently healthy school aged Saudi children (aged 6–15 years), attending primary and intermediate schools in Riyadh between 2014 and 2016, for H. pylori seropositivity by checking for the presence of anti-H. pylori IgG and IgA antibodies in serum specimens.
Results: Out of 3551 serum specimens, 1413 cases tested seropositive for H. pylori organism (40%): 430 (12.2%) were both IgG and IgA positive, 212 (6%) and 771 (21.7%) cases showed isolated positivity for IgG or IgA, respectively. Male gender, older age, lower levels of socioeconomic status (SES), and family members >10 were significantly associated with H. pylori seropositivity. The proportion of participants with short stature was significantly more in the H. pylori seropositive group than the seronegative group (OR1.249, confidence interval [1.020–1.531], P= 0.033). There was no significant association between H. pylori seropositivity and gastrointestinal symptoms.
Conclusion: The prevalence of H. pylori seropositivity among apparently healthy Saudi children (40%) is intermediate compared with that in developed and developing countries. The Saudi pediatric population shows a predominant IgA-type immunological response to H. pylori infection. |
| first_indexed | 2024-12-10T09:38:04Z |
| format | Article |
| id | doaj.art-20af4dda24c641c68da76532d877c097 |
| institution | Directory Open Access Journal |
| issn | 1319-3767 1998-4049 |
| language | English |
| last_indexed | 2024-12-10T09:38:04Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Saudi Journal of Gastroenterology |
| spelling | doaj.art-20af4dda24c641c68da76532d877c0972022-12-22T01:54:06ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492019-01-0125530931810.4103/sjg.SJG_531_18Where are we today with Helicobacter pylori infection among healthy children in Saudi Arabia?Abdulrahman A Al-HussainiAbdullah N Al JurayyanSalman M BashirDayel AlshahraniBackground/Aims: The available studies on Helicobacter pylori (H. pylori) prevalence among healthy asymptomatic population across Saudi Arabia suffers from significant limitations. We conducted this large population-based study to estimate the H. pylori seropositivity rate among apparently healthy children in Saudi Arabia, using anti-H. pylori immunoglobulin A (IgA) and IgG serology tests, and to study the influence of H. pylori infection on growth. Materials and Methods: We conducted a cross-sectional study to screen apparently healthy school aged Saudi children (aged 6–15 years), attending primary and intermediate schools in Riyadh between 2014 and 2016, for H. pylori seropositivity by checking for the presence of anti-H. pylori IgG and IgA antibodies in serum specimens. Results: Out of 3551 serum specimens, 1413 cases tested seropositive for H. pylori organism (40%): 430 (12.2%) were both IgG and IgA positive, 212 (6%) and 771 (21.7%) cases showed isolated positivity for IgG or IgA, respectively. Male gender, older age, lower levels of socioeconomic status (SES), and family members >10 were significantly associated with H. pylori seropositivity. The proportion of participants with short stature was significantly more in the H. pylori seropositive group than the seronegative group (OR1.249, confidence interval [1.020–1.531], P= 0.033). There was no significant association between H. pylori seropositivity and gastrointestinal symptoms. Conclusion: The prevalence of H. pylori seropositivity among apparently healthy Saudi children (40%) is intermediate compared with that in developed and developing countries. The Saudi pediatric population shows a predominant IgA-type immunological response to H. pylori infection.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2019;volume=25;issue=5;spage=309;epage=318;aulast=Al-HussainiEpidemiologyHelicobacter pyloriprevalenceRiyadhshort staturesocioeconomic status |
| spellingShingle | Abdulrahman A Al-Hussaini Abdullah N Al Jurayyan Salman M Bashir Dayel Alshahrani Where are we today with Helicobacter pylori infection among healthy children in Saudi Arabia? The Saudi Journal of Gastroenterology Epidemiology Helicobacter pylori prevalence Riyadh short stature socioeconomic status |
| title | Where are we today with Helicobacter pylori infection among healthy children in Saudi Arabia? |
| title_full | Where are we today with Helicobacter pylori infection among healthy children in Saudi Arabia? |
| title_fullStr | Where are we today with Helicobacter pylori infection among healthy children in Saudi Arabia? |
| title_full_unstemmed | Where are we today with Helicobacter pylori infection among healthy children in Saudi Arabia? |
| title_short | Where are we today with Helicobacter pylori infection among healthy children in Saudi Arabia? |
| title_sort | where are we today with helicobacter pylori infection among healthy children in saudi arabia |
| topic | Epidemiology Helicobacter pylori prevalence Riyadh short stature socioeconomic status |
| url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2019;volume=25;issue=5;spage=309;epage=318;aulast=Al-Hussaini |
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