Hazop Analysis of a Bioprocess for Polyhydroxyalkanoate (PHA) Production from Organic Waste: Part A
The number of bioprocesses for the circular economy of organic waste has grown in recent years. Implementation of new processes and technologies should consider occupational health and safety issues from the initial design stages. Among the process hazards analysis techniques, HAZard and OPerability...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | Fermentation |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2311-5637/9/2/99 |
| _version_ | 1797621077602467840 |
|---|---|
| author | Roberto Lauri Emma Incocciati Biancamaria Pietrangeli Lionel Nguemna Tayou Francesco Valentino Marco Gottardo Mauro Majone |
| author_facet | Roberto Lauri Emma Incocciati Biancamaria Pietrangeli Lionel Nguemna Tayou Francesco Valentino Marco Gottardo Mauro Majone |
| author_sort | Roberto Lauri |
| collection | DOAJ |
| description | The number of bioprocesses for the circular economy of organic waste has grown in recent years. Implementation of new processes and technologies should consider occupational health and safety issues from the initial design stages. Among the process hazards analysis techniques, HAZard and OPerability (HAZOP) methodology is widely used for studying both the process’s hazards and their operability problems, by exploring the effects of any deviations from design conditions. In the present study, a modified version of HAZOP methodology has been applied to a three-steps process developed at pilot scale in the Treviso municipal wastewater treatment plant in order to produce polyhydroxyalkanoate (PHA) as the final high value product. This paper shows the results of HAZOP analysis applied to the first process step (acidogenic fermentation) aimed at volatile fatty acids production. The analysis has been applied to the process conditions corresponding to the maximum PHA content in the biomass. The HAZOP study results showed that this methodology allowed a comprehensive exploration of conventional chemical engineering process hazards and biological hazards. Final piping and instrumentation diagrams (P&IDs) for acidogenic fermentation have been designed, identifying all prevention measures aimed at managing the hazard and operability issues. The P&ID shows the interconnection of equipment and the instrumentation required for controlling the process. |
| first_indexed | 2024-03-11T08:50:32Z |
| format | Article |
| id | doaj.art-20af755f70ed4ed69d265eb36c62b3fb |
| institution | Directory Open Access Journal |
| issn | 2311-5637 |
| language | English |
| last_indexed | 2024-03-11T08:50:32Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Fermentation |
| spelling | doaj.art-20af755f70ed4ed69d265eb36c62b3fb2023-11-16T20:25:26ZengMDPI AGFermentation2311-56372023-01-01929910.3390/fermentation9020099Hazop Analysis of a Bioprocess for Polyhydroxyalkanoate (PHA) Production from Organic Waste: Part ARoberto Lauri0Emma Incocciati1Biancamaria Pietrangeli2Lionel Nguemna Tayou3Francesco Valentino4Marco Gottardo5Mauro Majone6Inail, Department of Technological Innovations and Safety of Plants, Products and Human Settlements, Via del Torraccio di Torrenova 7, 00133 Rome, ItalyInail, Advisory Department for Risks Assessment and Prevention, Via Roberto Ferruzzi 38/40, 00143 Rome, ItalyInail, Department of Technological Innovations and Safety of Plants, Products and Human Settlements, Via Roberto Ferruzzi 38/40, 00143 Rome, ItalyDepartment of Chemistry, “La Sapienza” University of Rome, P.le Aldo Moro 5, 00185 Rome, ItalyDepartment of Environmental Sciences, Informatics and Statistics, Cà Foscari University of Venice, Via Torino 155, 30170 Mestre-Venice, ItalyDepartment of Environmental Sciences, Informatics and Statistics, Cà Foscari University of Venice, Via Torino 155, 30170 Mestre-Venice, ItalyDepartment of Chemistry, “La Sapienza” University of Rome, P.le Aldo Moro 5, 00185 Rome, ItalyThe number of bioprocesses for the circular economy of organic waste has grown in recent years. Implementation of new processes and technologies should consider occupational health and safety issues from the initial design stages. Among the process hazards analysis techniques, HAZard and OPerability (HAZOP) methodology is widely used for studying both the process’s hazards and their operability problems, by exploring the effects of any deviations from design conditions. In the present study, a modified version of HAZOP methodology has been applied to a three-steps process developed at pilot scale in the Treviso municipal wastewater treatment plant in order to produce polyhydroxyalkanoate (PHA) as the final high value product. This paper shows the results of HAZOP analysis applied to the first process step (acidogenic fermentation) aimed at volatile fatty acids production. The analysis has been applied to the process conditions corresponding to the maximum PHA content in the biomass. The HAZOP study results showed that this methodology allowed a comprehensive exploration of conventional chemical engineering process hazards and biological hazards. Final piping and instrumentation diagrams (P&IDs) for acidogenic fermentation have been designed, identifying all prevention measures aimed at managing the hazard and operability issues. The P&ID shows the interconnection of equipment and the instrumentation required for controlling the process.https://www.mdpi.com/2311-5637/9/2/99bioprocesspolyhydroxyalkanoatesHAZOP analysisoccupational health and safetyoperabilityP&ID |
| spellingShingle | Roberto Lauri Emma Incocciati Biancamaria Pietrangeli Lionel Nguemna Tayou Francesco Valentino Marco Gottardo Mauro Majone Hazop Analysis of a Bioprocess for Polyhydroxyalkanoate (PHA) Production from Organic Waste: Part A Fermentation bioprocess polyhydroxyalkanoates HAZOP analysis occupational health and safety operability P&ID |
| title | Hazop Analysis of a Bioprocess for Polyhydroxyalkanoate (PHA) Production from Organic Waste: Part A |
| title_full | Hazop Analysis of a Bioprocess for Polyhydroxyalkanoate (PHA) Production from Organic Waste: Part A |
| title_fullStr | Hazop Analysis of a Bioprocess for Polyhydroxyalkanoate (PHA) Production from Organic Waste: Part A |
| title_full_unstemmed | Hazop Analysis of a Bioprocess for Polyhydroxyalkanoate (PHA) Production from Organic Waste: Part A |
| title_short | Hazop Analysis of a Bioprocess for Polyhydroxyalkanoate (PHA) Production from Organic Waste: Part A |
| title_sort | hazop analysis of a bioprocess for polyhydroxyalkanoate pha production from organic waste part a |
| topic | bioprocess polyhydroxyalkanoates HAZOP analysis occupational health and safety operability P&ID |
| url | https://www.mdpi.com/2311-5637/9/2/99 |
| work_keys_str_mv | AT robertolauri hazopanalysisofabioprocessforpolyhydroxyalkanoatephaproductionfromorganicwasteparta AT emmaincocciati hazopanalysisofabioprocessforpolyhydroxyalkanoatephaproductionfromorganicwasteparta AT biancamariapietrangeli hazopanalysisofabioprocessforpolyhydroxyalkanoatephaproductionfromorganicwasteparta AT lionelnguemnatayou hazopanalysisofabioprocessforpolyhydroxyalkanoatephaproductionfromorganicwasteparta AT francescovalentino hazopanalysisofabioprocessforpolyhydroxyalkanoatephaproductionfromorganicwasteparta AT marcogottardo hazopanalysisofabioprocessforpolyhydroxyalkanoatephaproductionfromorganicwasteparta AT mauromajone hazopanalysisofabioprocessforpolyhydroxyalkanoatephaproductionfromorganicwasteparta |