Local tuning of radiomics-based model for predicting pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Abstract Purpose This study aims to further enhance a validated radiomics-based model for predicting pathologic complete response (pCR) after chemo‑radiotherapy in locally advanced rectal cancer (LARC) for use in clinical practice. Methods A generalized linear model (GLM) to predict pCR in LARC pati...

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Main Authors: Bin Tang, Jacopo Lenkowicz, Qian Peng, Luca Boldrini, Qing Hou, Nicola Dinapoli, Vincenzo Valentini, Peng Diao, Gang Yin, Lucia Clara Orlandini
Format: Article
Language:English
Published: BMC 2022-03-01
Series:BMC Medical Imaging
Subjects:
Online Access:https://doi.org/10.1186/s12880-022-00773-x
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author Bin Tang
Jacopo Lenkowicz
Qian Peng
Luca Boldrini
Qing Hou
Nicola Dinapoli
Vincenzo Valentini
Peng Diao
Gang Yin
Lucia Clara Orlandini
author_facet Bin Tang
Jacopo Lenkowicz
Qian Peng
Luca Boldrini
Qing Hou
Nicola Dinapoli
Vincenzo Valentini
Peng Diao
Gang Yin
Lucia Clara Orlandini
author_sort Bin Tang
collection DOAJ
description Abstract Purpose This study aims to further enhance a validated radiomics-based model for predicting pathologic complete response (pCR) after chemo‑radiotherapy in locally advanced rectal cancer (LARC) for use in clinical practice. Methods A generalized linear model (GLM) to predict pCR in LARC patients previously trained in Europe and validated with an external inter-continental cohort (59 patients), was first examined with further 88 intercontinental patient datasets to assess its reproducibility; then new radiomics and clinical features, and validation methods were investigated to build a new model for enhancing the pCR prediction for patients admitted to our department. The patients were divided into training group (75%) and validation group (25%) according to their demographic. The least absolute shrinkage and selection operator (LASSO) logistic regression was used to reduce the dimensionality of the extracted features of the training group and select the optimal ones; the performance of the reference GLM and enhanced models was compared through the area under curve (AUC) of the receiver operating characteristics. Results The value of AUC of the reference model was 0.831 (95% CI, 0.701–0.961), and 0.828 (95% CI, 0.700–0.956) in the original and new validation cohorts, respectively, showing a reproducibility in the applicability of the GLM model. Eight features were found to be significant with LASSO and used to establish an enhanced model. The AUC of the enhanced model of 0.926 (95% CI, 0.859–0.993) for training, and 0.926 (95% CI, 0.767–1.00) for the validation group shows better performance than the reference model. Conclusions The GLM model shows good reproducibility in predicting pCR in LARC; the enhanced model has the potential to improve prediction accuracy and may be a candidate in clinical practice.
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spelling doaj.art-20b0d253d3b949458b620cb14427fc922022-12-21T23:32:58ZengBMCBMC Medical Imaging1471-23422022-03-012211810.1186/s12880-022-00773-xLocal tuning of radiomics-based model for predicting pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancerBin Tang0Jacopo Lenkowicz1Qian Peng2Luca Boldrini3Qing Hou4Nicola Dinapoli5Vincenzo Valentini6Peng Diao7Gang Yin8Lucia Clara Orlandini9Key Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan UniversityDipartimento Scienze Radiologiche, Fondazione Policlinico Universitario “A. Gemelli” IRCCSDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Cancer Hospital and InstituteDipartimento Scienze Radiologiche, Fondazione Policlinico Universitario “A. Gemelli” IRCCSKey Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan UniversityDipartimento Scienze Radiologiche, Fondazione Policlinico Universitario “A. Gemelli” IRCCSDipartimento Scienze Radiologiche, Fondazione Policlinico Universitario “A. Gemelli” IRCCSDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Cancer Hospital and InstituteDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Cancer Hospital and InstituteDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Cancer Hospital and InstituteAbstract Purpose This study aims to further enhance a validated radiomics-based model for predicting pathologic complete response (pCR) after chemo‑radiotherapy in locally advanced rectal cancer (LARC) for use in clinical practice. Methods A generalized linear model (GLM) to predict pCR in LARC patients previously trained in Europe and validated with an external inter-continental cohort (59 patients), was first examined with further 88 intercontinental patient datasets to assess its reproducibility; then new radiomics and clinical features, and validation methods were investigated to build a new model for enhancing the pCR prediction for patients admitted to our department. The patients were divided into training group (75%) and validation group (25%) according to their demographic. The least absolute shrinkage and selection operator (LASSO) logistic regression was used to reduce the dimensionality of the extracted features of the training group and select the optimal ones; the performance of the reference GLM and enhanced models was compared through the area under curve (AUC) of the receiver operating characteristics. Results The value of AUC of the reference model was 0.831 (95% CI, 0.701–0.961), and 0.828 (95% CI, 0.700–0.956) in the original and new validation cohorts, respectively, showing a reproducibility in the applicability of the GLM model. Eight features were found to be significant with LASSO and used to establish an enhanced model. The AUC of the enhanced model of 0.926 (95% CI, 0.859–0.993) for training, and 0.926 (95% CI, 0.767–1.00) for the validation group shows better performance than the reference model. Conclusions The GLM model shows good reproducibility in predicting pCR in LARC; the enhanced model has the potential to improve prediction accuracy and may be a candidate in clinical practice.https://doi.org/10.1186/s12880-022-00773-xRadiomicsRectumPredictive modelsPathological complete responseLASSO
spellingShingle Bin Tang
Jacopo Lenkowicz
Qian Peng
Luca Boldrini
Qing Hou
Nicola Dinapoli
Vincenzo Valentini
Peng Diao
Gang Yin
Lucia Clara Orlandini
Local tuning of radiomics-based model for predicting pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer
BMC Medical Imaging
Radiomics
Rectum
Predictive models
Pathological complete response
LASSO
title Local tuning of radiomics-based model for predicting pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer
title_full Local tuning of radiomics-based model for predicting pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer
title_fullStr Local tuning of radiomics-based model for predicting pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer
title_full_unstemmed Local tuning of radiomics-based model for predicting pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer
title_short Local tuning of radiomics-based model for predicting pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer
title_sort local tuning of radiomics based model for predicting pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer
topic Radiomics
Rectum
Predictive models
Pathological complete response
LASSO
url https://doi.org/10.1186/s12880-022-00773-x
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