Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis
Drug-resistant tuberculosis (TB) is a growing global threat. Approximately 450,000 people developed multidrug-resistant TB worldwide in 2012 and an estimated 170,000 people died from the disease. This paper describes the sociodemographic, clinical-epidemiological and bacteriological aspects of TB an...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
2015-04-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000200235&lng=en&tlng=en |
| _version_ | 1827879596750536704 |
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| author | Heloisa da Silveira Paro Pedro Susilene Maria Tonelli Nardi Maria Izabel Ferreira Pereira Rosângela Siqueira Oliveira Philip Noel Suffys Harrison Magdinier Gomes Amanda Juliane Finardi Eloise Brasil de Moraes Ida Maria Foschiani Dias Baptista Ricardo Luiz Dantas Machado Lilian Castiglioni |
| author_facet | Heloisa da Silveira Paro Pedro Susilene Maria Tonelli Nardi Maria Izabel Ferreira Pereira Rosângela Siqueira Oliveira Philip Noel Suffys Harrison Magdinier Gomes Amanda Juliane Finardi Eloise Brasil de Moraes Ida Maria Foschiani Dias Baptista Ricardo Luiz Dantas Machado Lilian Castiglioni |
| author_sort | Heloisa da Silveira Paro Pedro |
| collection | DOAJ |
| description | Drug-resistant tuberculosis (TB) is a growing global threat. Approximately 450,000 people developed multidrug-resistant TB worldwide in 2012 and an estimated 170,000 people died from the disease. This paper describes the sociodemographic, clinical-epidemiological and bacteriological aspects of TB and correlates these features with the distribution of anti-TB drug resistance. Mycobacterium tuberculosis (MT) cultures and drug susceptibility testing were performed according to the BACTEC MGIT 960 method. The results demonstrated that MT strains from individuals who received treatment for TB and people who were infected with human immunodeficiency virus were more resistant to TB drugs compared to other individuals (p < 0.05). Approximately half of the individuals received supervised treatment, but most drug-resistant cases were positive for pulmonary TB and exhibited positive acid-fast bacilli smears, which are complicating factors for TB control programs. Primary healthcare is the ideal level for early disease detection, but tertiary healthcare is the most common entry point for patients into the system. These factors require special attention from healthcare managers and professionals to effectively control and monitor the spread of TB drug-resistant cases. |
| first_indexed | 2024-03-12T18:09:05Z |
| format | Article |
| id | doaj.art-20b20583baa843c0a009baf45032b5f9 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:09:05Z |
| publishDate | 2015-04-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-20b20583baa843c0a009baf45032b5f92023-08-02T09:16:37ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602015-04-01110223524810.1590/0074-02760140316S0074-02762015000200235Clinical and epidemiological profiles of individuals with drug-resistant tuberculosisHeloisa da Silveira Paro PedroSusilene Maria Tonelli NardiMaria Izabel Ferreira PereiraRosângela Siqueira OliveiraPhilip Noel SuffysHarrison Magdinier GomesAmanda Juliane FinardiEloise Brasil de MoraesIda Maria Foschiani Dias BaptistaRicardo Luiz Dantas MachadoLilian CastiglioniDrug-resistant tuberculosis (TB) is a growing global threat. Approximately 450,000 people developed multidrug-resistant TB worldwide in 2012 and an estimated 170,000 people died from the disease. This paper describes the sociodemographic, clinical-epidemiological and bacteriological aspects of TB and correlates these features with the distribution of anti-TB drug resistance. Mycobacterium tuberculosis (MT) cultures and drug susceptibility testing were performed according to the BACTEC MGIT 960 method. The results demonstrated that MT strains from individuals who received treatment for TB and people who were infected with human immunodeficiency virus were more resistant to TB drugs compared to other individuals (p < 0.05). Approximately half of the individuals received supervised treatment, but most drug-resistant cases were positive for pulmonary TB and exhibited positive acid-fast bacilli smears, which are complicating factors for TB control programs. Primary healthcare is the ideal level for early disease detection, but tertiary healthcare is the most common entry point for patients into the system. These factors require special attention from healthcare managers and professionals to effectively control and monitor the spread of TB drug-resistant cases.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000200235&lng=en&tlng=entuberculosisdiagnosisantimicrobial resistance |
| spellingShingle | Heloisa da Silveira Paro Pedro Susilene Maria Tonelli Nardi Maria Izabel Ferreira Pereira Rosângela Siqueira Oliveira Philip Noel Suffys Harrison Magdinier Gomes Amanda Juliane Finardi Eloise Brasil de Moraes Ida Maria Foschiani Dias Baptista Ricardo Luiz Dantas Machado Lilian Castiglioni Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis Memorias do Instituto Oswaldo Cruz tuberculosis diagnosis antimicrobial resistance |
| title | Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis |
| title_full | Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis |
| title_fullStr | Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis |
| title_full_unstemmed | Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis |
| title_short | Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis |
| title_sort | clinical and epidemiological profiles of individuals with drug resistant tuberculosis |
| topic | tuberculosis diagnosis antimicrobial resistance |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000200235&lng=en&tlng=en |
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