Cancer-derived exosomes as novel biomarkers in metastatic gastrointestinal cancer
Abstract Gastrointestinal cancer (GIC) is the most prevalent and highly metastatic malignant tumor and has a significant impact on mortality rates. Nevertheless, the swift advancement of contemporary technology has not seamlessly aligned with the evolution of detection methodologies, resulting in a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-024-01948-6 |
| _version_ | 1797219980571312128 |
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| author | Danyang Zhong Ziyuan Wang Zhichao Ye Yifan Wang Xiujun Cai |
| author_facet | Danyang Zhong Ziyuan Wang Zhichao Ye Yifan Wang Xiujun Cai |
| author_sort | Danyang Zhong |
| collection | DOAJ |
| description | Abstract Gastrointestinal cancer (GIC) is the most prevalent and highly metastatic malignant tumor and has a significant impact on mortality rates. Nevertheless, the swift advancement of contemporary technology has not seamlessly aligned with the evolution of detection methodologies, resulting in a deficit of innovative and efficient clinical assays for GIC. Given that exosomes are preferentially released by a myriad of cellular entities, predominantly originating from neoplastic cells, this confers exosomes with a composition enriched in cancer-specific constituents. Furthermore, exosomes exhibit ubiquitous presence across diverse biological fluids, endowing them with the inherent advantages of non-invasiveness, real-time monitoring, and tumor specificity. The unparalleled advantages inherent in exosomes render them as an ideal liquid biopsy biomarker for early diagnosis, prognosticating the potential development of GIC metastasis. In this review, we summarized the latest research progress and possible potential targets on cancer-derived exosomes (CDEs) in GIC with an emphasis on the mechanisms of exosome promoting cancer metastasis, highlighting the potential roles of CDEs as the biomarker and treatment in metastatic GIC. |
| first_indexed | 2024-04-24T12:42:16Z |
| format | Article |
| id | doaj.art-20b218e846d947c5a783edd9ed36db22 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-04-24T12:42:16Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-20b218e846d947c5a783edd9ed36db222024-04-07T11:10:38ZengBMCMolecular Cancer1476-45982024-04-0123112610.1186/s12943-024-01948-6Cancer-derived exosomes as novel biomarkers in metastatic gastrointestinal cancerDanyang Zhong0Ziyuan Wang1Zhichao Ye2Yifan Wang3Xiujun Cai4Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineAbstract Gastrointestinal cancer (GIC) is the most prevalent and highly metastatic malignant tumor and has a significant impact on mortality rates. Nevertheless, the swift advancement of contemporary technology has not seamlessly aligned with the evolution of detection methodologies, resulting in a deficit of innovative and efficient clinical assays for GIC. Given that exosomes are preferentially released by a myriad of cellular entities, predominantly originating from neoplastic cells, this confers exosomes with a composition enriched in cancer-specific constituents. Furthermore, exosomes exhibit ubiquitous presence across diverse biological fluids, endowing them with the inherent advantages of non-invasiveness, real-time monitoring, and tumor specificity. The unparalleled advantages inherent in exosomes render them as an ideal liquid biopsy biomarker for early diagnosis, prognosticating the potential development of GIC metastasis. In this review, we summarized the latest research progress and possible potential targets on cancer-derived exosomes (CDEs) in GIC with an emphasis on the mechanisms of exosome promoting cancer metastasis, highlighting the potential roles of CDEs as the biomarker and treatment in metastatic GIC.https://doi.org/10.1186/s12943-024-01948-6ExosomesMetastasisBiomarkerGastrointestinal cancer |
| spellingShingle | Danyang Zhong Ziyuan Wang Zhichao Ye Yifan Wang Xiujun Cai Cancer-derived exosomes as novel biomarkers in metastatic gastrointestinal cancer Molecular Cancer Exosomes Metastasis Biomarker Gastrointestinal cancer |
| title | Cancer-derived exosomes as novel biomarkers in metastatic gastrointestinal cancer |
| title_full | Cancer-derived exosomes as novel biomarkers in metastatic gastrointestinal cancer |
| title_fullStr | Cancer-derived exosomes as novel biomarkers in metastatic gastrointestinal cancer |
| title_full_unstemmed | Cancer-derived exosomes as novel biomarkers in metastatic gastrointestinal cancer |
| title_short | Cancer-derived exosomes as novel biomarkers in metastatic gastrointestinal cancer |
| title_sort | cancer derived exosomes as novel biomarkers in metastatic gastrointestinal cancer |
| topic | Exosomes Metastasis Biomarker Gastrointestinal cancer |
| url | https://doi.org/10.1186/s12943-024-01948-6 |
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