Role of Sex Hormones on Brain Mitochondrial Function, with Special Reference to Aging and Neurodegenerative Diseases
The mitochondria have a fundamental role in both cellular energy supply and oxidative stress regulation and are target of the effects of sex steroids, particularly the neuroprotective ones. Aging is associated with a decline in the levels of different steroid hormones, and this decrease may underlin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-12-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fnagi.2017.00406/full |
| _version_ | 1811201303856021504 |
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| author | Pauline Gaignard Pauline Gaignard Philippe Liere Patrice Thérond Michael Schumacher Abdelhamid Slama Rachida Guennoun |
| author_facet | Pauline Gaignard Pauline Gaignard Philippe Liere Patrice Thérond Michael Schumacher Abdelhamid Slama Rachida Guennoun |
| author_sort | Pauline Gaignard |
| collection | DOAJ |
| description | The mitochondria have a fundamental role in both cellular energy supply and oxidative stress regulation and are target of the effects of sex steroids, particularly the neuroprotective ones. Aging is associated with a decline in the levels of different steroid hormones, and this decrease may underline some neural dysfunctions. Besides, modifications in mitochondrial functions associated with aging processes are also well documented. In this review, we will discuss studies that describe the modifications of brain mitochondrial function and of steroid levels associated with physiological aging and with neurodegenerative diseases. A special emphasis will be placed on describing and discussing our recent findings concerning the concomitant study of mitochondrial function (oxidative phosphorylation, oxidative stress) and brain steroid levels in both young (3-month-old) and aged (20-month-old) male and female mice. |
| first_indexed | 2024-04-12T02:19:42Z |
| format | Article |
| id | doaj.art-20b32fcc9e5b4ef59445b1d206eca7a0 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T02:19:42Z |
| publishDate | 2017-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-20b32fcc9e5b4ef59445b1d206eca7a02022-12-22T03:52:09ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652017-12-01910.3389/fnagi.2017.00406318013Role of Sex Hormones on Brain Mitochondrial Function, with Special Reference to Aging and Neurodegenerative DiseasesPauline Gaignard0Pauline Gaignard1Philippe Liere2Patrice Thérond3Michael Schumacher4Abdelhamid Slama5Rachida Guennoun6U1195 Inserm and University Paris-Sud and University Paris-Saclay, Le Kremlin-Bicêtre, FranceBiochemistry Laboratory, Bicêtre Hospital, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, FranceU1195 Inserm and University Paris-Sud and University Paris-Saclay, Le Kremlin-Bicêtre, FranceBiochemistry Laboratory, Bicêtre Hospital, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, FranceU1195 Inserm and University Paris-Sud and University Paris-Saclay, Le Kremlin-Bicêtre, FranceBiochemistry Laboratory, Bicêtre Hospital, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, FranceU1195 Inserm and University Paris-Sud and University Paris-Saclay, Le Kremlin-Bicêtre, FranceThe mitochondria have a fundamental role in both cellular energy supply and oxidative stress regulation and are target of the effects of sex steroids, particularly the neuroprotective ones. Aging is associated with a decline in the levels of different steroid hormones, and this decrease may underline some neural dysfunctions. Besides, modifications in mitochondrial functions associated with aging processes are also well documented. In this review, we will discuss studies that describe the modifications of brain mitochondrial function and of steroid levels associated with physiological aging and with neurodegenerative diseases. A special emphasis will be placed on describing and discussing our recent findings concerning the concomitant study of mitochondrial function (oxidative phosphorylation, oxidative stress) and brain steroid levels in both young (3-month-old) and aged (20-month-old) male and female mice.http://journal.frontiersin.org/article/10.3389/fnagi.2017.00406/fullagingprogesteroneestrogensoxidative phosphorylationoxidative stresssex differences |
| spellingShingle | Pauline Gaignard Pauline Gaignard Philippe Liere Patrice Thérond Michael Schumacher Abdelhamid Slama Rachida Guennoun Role of Sex Hormones on Brain Mitochondrial Function, with Special Reference to Aging and Neurodegenerative Diseases Frontiers in Aging Neuroscience aging progesterone estrogens oxidative phosphorylation oxidative stress sex differences |
| title | Role of Sex Hormones on Brain Mitochondrial Function, with Special Reference to Aging and Neurodegenerative Diseases |
| title_full | Role of Sex Hormones on Brain Mitochondrial Function, with Special Reference to Aging and Neurodegenerative Diseases |
| title_fullStr | Role of Sex Hormones on Brain Mitochondrial Function, with Special Reference to Aging and Neurodegenerative Diseases |
| title_full_unstemmed | Role of Sex Hormones on Brain Mitochondrial Function, with Special Reference to Aging and Neurodegenerative Diseases |
| title_short | Role of Sex Hormones on Brain Mitochondrial Function, with Special Reference to Aging and Neurodegenerative Diseases |
| title_sort | role of sex hormones on brain mitochondrial function with special reference to aging and neurodegenerative diseases |
| topic | aging progesterone estrogens oxidative phosphorylation oxidative stress sex differences |
| url | http://journal.frontiersin.org/article/10.3389/fnagi.2017.00406/full |
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