New-Onset Kidney Diseases after COVID-19 Vaccination: A Case Series
Various vaccines against COVID-19 have been developed and proven to be effective, but their side effects, especially on kidney function, are not yet known in detail. In this study, we report the clinical courses and histopathologic findings of new-onset kidney diseases after COVID-19 vaccination as...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/10/2/302 |
| _version_ | 1797476104872656896 |
|---|---|
| author | Jeong-Hoon Lim Mee-Seon Kim Yong-Jin Kim Man-Hoon Han Hee-Yeon Jung Ji-Young Choi Jang-Hee Cho Chan-Duck Kim Yong-Lim Kim Sun-Hee Park |
| author_facet | Jeong-Hoon Lim Mee-Seon Kim Yong-Jin Kim Man-Hoon Han Hee-Yeon Jung Ji-Young Choi Jang-Hee Cho Chan-Duck Kim Yong-Lim Kim Sun-Hee Park |
| author_sort | Jeong-Hoon Lim |
| collection | DOAJ |
| description | Various vaccines against COVID-19 have been developed and proven to be effective, but their side effects, especially on kidney function, are not yet known in detail. In this study, we report the clinical courses and histopathologic findings of new-onset kidney diseases after COVID-19 vaccination as confirmed via kidney biopsy. Five patients aged 42 to 77 years were included in this study, and baseline kidney function was normal in all patients. The biopsy-proven diagnosis indicated newly developed kidney diseases: (1) IgA nephropathy presenting with painless gross hematuria, (2) minimal change disease presenting with nephrotic syndrome, (3) thrombotic microangiopathy, and (4) two cases of acute tubulointerstitial nephritis presenting with acute kidney injury. Individualized treatment was applied as per disease severity and underlying pathology, and the treatment outcomes of all patients were improved. Since this is not a controlled study, the specific pathophysiologic link and causality between the incidence of kidney diseases and COVID-19 vaccination are difficult to confirm. However, clinicians need to consider the possibility that kidney diseases may be provoked by vaccines in patients who have renal symptoms. |
| first_indexed | 2024-03-09T20:53:15Z |
| format | Article |
| id | doaj.art-20b3397e90994a9db565a0bb3cc699dd |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T20:53:15Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-20b3397e90994a9db565a0bb3cc699dd2023-11-23T22:26:51ZengMDPI AGVaccines2076-393X2022-02-0110230210.3390/vaccines10020302New-Onset Kidney Diseases after COVID-19 Vaccination: A Case SeriesJeong-Hoon Lim0Mee-Seon Kim1Yong-Jin Kim2Man-Hoon Han3Hee-Yeon Jung4Ji-Young Choi5Jang-Hee Cho6Chan-Duck Kim7Yong-Lim Kim8Sun-Hee Park9Division of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, KoreaDepartment of Pathology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, KoreaDepartment of Pathology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, KoreaDepartment of Pathology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, KoreaDivision of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, KoreaDivision of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, KoreaDivision of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, KoreaDivision of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, KoreaDivision of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, KoreaDivision of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, KoreaVarious vaccines against COVID-19 have been developed and proven to be effective, but their side effects, especially on kidney function, are not yet known in detail. In this study, we report the clinical courses and histopathologic findings of new-onset kidney diseases after COVID-19 vaccination as confirmed via kidney biopsy. Five patients aged 42 to 77 years were included in this study, and baseline kidney function was normal in all patients. The biopsy-proven diagnosis indicated newly developed kidney diseases: (1) IgA nephropathy presenting with painless gross hematuria, (2) minimal change disease presenting with nephrotic syndrome, (3) thrombotic microangiopathy, and (4) two cases of acute tubulointerstitial nephritis presenting with acute kidney injury. Individualized treatment was applied as per disease severity and underlying pathology, and the treatment outcomes of all patients were improved. Since this is not a controlled study, the specific pathophysiologic link and causality between the incidence of kidney diseases and COVID-19 vaccination are difficult to confirm. However, clinicians need to consider the possibility that kidney diseases may be provoked by vaccines in patients who have renal symptoms.https://www.mdpi.com/2076-393X/10/2/302COVID-19vaccinationkidney diseasekidney biopsyIgA nephropathyminimal change disease |
| spellingShingle | Jeong-Hoon Lim Mee-Seon Kim Yong-Jin Kim Man-Hoon Han Hee-Yeon Jung Ji-Young Choi Jang-Hee Cho Chan-Duck Kim Yong-Lim Kim Sun-Hee Park New-Onset Kidney Diseases after COVID-19 Vaccination: A Case Series Vaccines COVID-19 vaccination kidney disease kidney biopsy IgA nephropathy minimal change disease |
| title | New-Onset Kidney Diseases after COVID-19 Vaccination: A Case Series |
| title_full | New-Onset Kidney Diseases after COVID-19 Vaccination: A Case Series |
| title_fullStr | New-Onset Kidney Diseases after COVID-19 Vaccination: A Case Series |
| title_full_unstemmed | New-Onset Kidney Diseases after COVID-19 Vaccination: A Case Series |
| title_short | New-Onset Kidney Diseases after COVID-19 Vaccination: A Case Series |
| title_sort | new onset kidney diseases after covid 19 vaccination a case series |
| topic | COVID-19 vaccination kidney disease kidney biopsy IgA nephropathy minimal change disease |
| url | https://www.mdpi.com/2076-393X/10/2/302 |
| work_keys_str_mv | AT jeonghoonlim newonsetkidneydiseasesaftercovid19vaccinationacaseseries AT meeseonkim newonsetkidneydiseasesaftercovid19vaccinationacaseseries AT yongjinkim newonsetkidneydiseasesaftercovid19vaccinationacaseseries AT manhoonhan newonsetkidneydiseasesaftercovid19vaccinationacaseseries AT heeyeonjung newonsetkidneydiseasesaftercovid19vaccinationacaseseries AT jiyoungchoi newonsetkidneydiseasesaftercovid19vaccinationacaseseries AT jangheecho newonsetkidneydiseasesaftercovid19vaccinationacaseseries AT chanduckkim newonsetkidneydiseasesaftercovid19vaccinationacaseseries AT yonglimkim newonsetkidneydiseasesaftercovid19vaccinationacaseseries AT sunheepark newonsetkidneydiseasesaftercovid19vaccinationacaseseries |