The efficacy and safety of Yupingfeng Powder with variation in the treatment of allergic rhinitis: Study protocol for a randomized, double-blind, placebo-controlled trial
Background: Allergic rhinitis (AR) is an upper airways chronic inflammatory disease mediated by IgE, which affects 10%–20% of the population. The mainstay for allergic rhinitis nowadays include steroids and antihistamines, but their effects are less than ideal. Many patients therefore seek Chinese m...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1058176/full |
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| author | Pui Kuan Cheong Pui Kuan Cheong Tin Muk Ho Tin Muk Ho Kam Leung Chan Kam Leung Chan Cho Wing Lo Cho Wing Lo Sin Bond Leung Sin Bond Leung Sin Bond Leung Kam Lun Hon Ka Chun Leung Tony Hon Chung Siu Tian-He Song Tian-He Song Hongwei Zhang Hongwei Zhang Jessica Yuet Ling Ching Jessica Yuet Ling Ching Jessica Yuet Ling Ching Tak Yee Chow Chi Him Sum Chi Him Sum Chon Pin Chia Zhi-Xiu Lin Zhi-Xiu Lin |
| author_facet | Pui Kuan Cheong Pui Kuan Cheong Tin Muk Ho Tin Muk Ho Kam Leung Chan Kam Leung Chan Cho Wing Lo Cho Wing Lo Sin Bond Leung Sin Bond Leung Sin Bond Leung Kam Lun Hon Ka Chun Leung Tony Hon Chung Siu Tian-He Song Tian-He Song Hongwei Zhang Hongwei Zhang Jessica Yuet Ling Ching Jessica Yuet Ling Ching Jessica Yuet Ling Ching Tak Yee Chow Chi Him Sum Chi Him Sum Chon Pin Chia Zhi-Xiu Lin Zhi-Xiu Lin |
| author_sort | Pui Kuan Cheong |
| collection | DOAJ |
| description | Background: Allergic rhinitis (AR) is an upper airways chronic inflammatory disease mediated by IgE, which affects 10%–20% of the population. The mainstay for allergic rhinitis nowadays include steroids and antihistamines, but their effects are less than ideal. Many patients therefore seek Chinese medicine for treatment and Yupingfeng Powder is one of the most common formulae prescribed. In this study, we aim to investigate the efficacy and safety of Yupingfeng Powder with variation for the treatment of allergic rhinitis.Study design: This is a double-blind, randomized, placebo-controlled trial. A 2-week screening period will be implemented, and then eligible subjects with allergic rhinitis will receive interventions of either “Yupingfeng Powder with variation” granules or placebo granules for 8 weeks, followed by post treatment visits at weeks 12 and 16. The change in the Total Nasal Symptom Score (TNSS) will be used as the primary outcome.Discussion: This trail will evaluate the efficacy and safety of Yupingfeng Powder in treating allergic rhinitis. The study may provide the solid evidence of Yupingfeng Powder with variation can produce better clinical efficacy than the placebo granules.Trial registration:ClinicalTrials.gov, identifier NCT04976023. |
| first_indexed | 2024-04-13T04:57:45Z |
| format | Article |
| id | doaj.art-20b37071fd344cfdafd289757a2bed82 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T04:57:45Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-20b37071fd344cfdafd289757a2bed822022-12-22T03:01:26ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-12-011310.3389/fphar.2022.10581761058176The efficacy and safety of Yupingfeng Powder with variation in the treatment of allergic rhinitis: Study protocol for a randomized, double-blind, placebo-controlled trialPui Kuan Cheong0Pui Kuan Cheong1Tin Muk Ho2Tin Muk Ho3Kam Leung Chan4Kam Leung Chan5Cho Wing Lo6Cho Wing Lo7Sin Bond Leung8Sin Bond Leung9Sin Bond Leung10Kam Lun Hon11Ka Chun Leung12Tony Hon Chung Siu13Tian-He Song14Tian-He Song15Hongwei Zhang16Hongwei Zhang17Jessica Yuet Ling Ching18Jessica Yuet Ling Ching19Jessica Yuet Ling Ching20Tak Yee Chow21Chi Him Sum22Chi Him Sum23Chon Pin Chia24Zhi-Xiu Lin25Zhi-Xiu Lin26Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaS. H. Ho Centre for Digestive Health, Institute of Digestive Disease, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaHong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaHong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaHong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaS. H. Ho Centre for Digestive Health, Institute of Digestive Disease, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaHong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaDepartment of Medicine and Geriatric, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, ChinaDepartment of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaHong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaHong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaHong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaHong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaHong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaS. H. Ho Centre for Digestive Health, Institute of Digestive Disease, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaHong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaHong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaHong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaHong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaBackground: Allergic rhinitis (AR) is an upper airways chronic inflammatory disease mediated by IgE, which affects 10%–20% of the population. The mainstay for allergic rhinitis nowadays include steroids and antihistamines, but their effects are less than ideal. Many patients therefore seek Chinese medicine for treatment and Yupingfeng Powder is one of the most common formulae prescribed. In this study, we aim to investigate the efficacy and safety of Yupingfeng Powder with variation for the treatment of allergic rhinitis.Study design: This is a double-blind, randomized, placebo-controlled trial. A 2-week screening period will be implemented, and then eligible subjects with allergic rhinitis will receive interventions of either “Yupingfeng Powder with variation” granules or placebo granules for 8 weeks, followed by post treatment visits at weeks 12 and 16. The change in the Total Nasal Symptom Score (TNSS) will be used as the primary outcome.Discussion: This trail will evaluate the efficacy and safety of Yupingfeng Powder in treating allergic rhinitis. The study may provide the solid evidence of Yupingfeng Powder with variation can produce better clinical efficacy than the placebo granules.Trial registration:ClinicalTrials.gov, identifier NCT04976023.https://www.frontiersin.org/articles/10.3389/fphar.2022.1058176/fullallergic rhinitisYupingfeng Powderrandomized control trialChinese medicineIgEefficacy and safety |
| spellingShingle | Pui Kuan Cheong Pui Kuan Cheong Tin Muk Ho Tin Muk Ho Kam Leung Chan Kam Leung Chan Cho Wing Lo Cho Wing Lo Sin Bond Leung Sin Bond Leung Sin Bond Leung Kam Lun Hon Ka Chun Leung Tony Hon Chung Siu Tian-He Song Tian-He Song Hongwei Zhang Hongwei Zhang Jessica Yuet Ling Ching Jessica Yuet Ling Ching Jessica Yuet Ling Ching Tak Yee Chow Chi Him Sum Chi Him Sum Chon Pin Chia Zhi-Xiu Lin Zhi-Xiu Lin The efficacy and safety of Yupingfeng Powder with variation in the treatment of allergic rhinitis: Study protocol for a randomized, double-blind, placebo-controlled trial Frontiers in Pharmacology allergic rhinitis Yupingfeng Powder randomized control trial Chinese medicine IgE efficacy and safety |
| title | The efficacy and safety of Yupingfeng Powder with variation in the treatment of allergic rhinitis: Study protocol for a randomized, double-blind, placebo-controlled trial |
| title_full | The efficacy and safety of Yupingfeng Powder with variation in the treatment of allergic rhinitis: Study protocol for a randomized, double-blind, placebo-controlled trial |
| title_fullStr | The efficacy and safety of Yupingfeng Powder with variation in the treatment of allergic rhinitis: Study protocol for a randomized, double-blind, placebo-controlled trial |
| title_full_unstemmed | The efficacy and safety of Yupingfeng Powder with variation in the treatment of allergic rhinitis: Study protocol for a randomized, double-blind, placebo-controlled trial |
| title_short | The efficacy and safety of Yupingfeng Powder with variation in the treatment of allergic rhinitis: Study protocol for a randomized, double-blind, placebo-controlled trial |
| title_sort | efficacy and safety of yupingfeng powder with variation in the treatment of allergic rhinitis study protocol for a randomized double blind placebo controlled trial |
| topic | allergic rhinitis Yupingfeng Powder randomized control trial Chinese medicine IgE efficacy and safety |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1058176/full |
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