SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies
Sterol regulatory element-binding proteins (SREBPs) are master transcription factors that play a crucial role in regulating genes involved in the biogenesis of cholesterol, fatty acids, and triglycerides. As such, they are implicated in several serious liver diseases, including non-alcoholic fatty l...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/12/3280 |
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| author | Na Li Xiaodan Li Yifu Ding Xiao Liu Karin Diggle Tatiana Kisseleva David A. Brenner |
| author_facet | Na Li Xiaodan Li Yifu Ding Xiao Liu Karin Diggle Tatiana Kisseleva David A. Brenner |
| author_sort | Na Li |
| collection | DOAJ |
| description | Sterol regulatory element-binding proteins (SREBPs) are master transcription factors that play a crucial role in regulating genes involved in the biogenesis of cholesterol, fatty acids, and triglycerides. As such, they are implicated in several serious liver diseases, including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), fibrosis, and hepatocellular carcinoma (HCC). SREBPs are subject to regulation by multiple cofactors and critical signaling pathways, making them an important target for therapeutic interventions. In this review, we first introduce the structure and activation of SREBPs, before focusing on their function in liver disease. We examine the mechanisms by which SREBPs regulate lipogenesis, explore how alterations in these processes are associated with liver disease, and evaluate potential therapeutic strategies using small molecules, natural products, or herb extracts that target these pathways. Through this analysis, we provide new insights into the versatility and multitargets of SREBPs as factors in the modulation of different physiological stages of liver disease, highlighting their potential targets for therapeutic treatment. |
| first_indexed | 2024-03-08T20:58:24Z |
| format | Article |
| id | doaj.art-20b433858dca49e4989ff7d29063ace9 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-08T20:58:24Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-20b433858dca49e4989ff7d29063ace92023-12-22T13:55:11ZengMDPI AGBiomedicines2227-90592023-12-011112328010.3390/biomedicines11123280SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic StrategiesNa Li0Xiaodan Li1Yifu Ding2Xiao Liu3Karin Diggle4Tatiana Kisseleva5David A. Brenner6College of Medical Technology, Shanghai University of Medicine & Health Sciences, Shanghai 201318, ChinaCollege of Medical Technology, Shanghai University of Medicine & Health Sciences, Shanghai 201318, ChinaState Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Shanghai 200031, ChinaDepartment of Surgery, University of California San Diego, La Jolla, CA 92093, USADepartment of Surgery, University of California San Diego, La Jolla, CA 92093, USADepartment of Surgery, University of California San Diego, La Jolla, CA 92093, USADepartment of Surgery, University of California San Diego, La Jolla, CA 92093, USASterol regulatory element-binding proteins (SREBPs) are master transcription factors that play a crucial role in regulating genes involved in the biogenesis of cholesterol, fatty acids, and triglycerides. As such, they are implicated in several serious liver diseases, including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), fibrosis, and hepatocellular carcinoma (HCC). SREBPs are subject to regulation by multiple cofactors and critical signaling pathways, making them an important target for therapeutic interventions. In this review, we first introduce the structure and activation of SREBPs, before focusing on their function in liver disease. We examine the mechanisms by which SREBPs regulate lipogenesis, explore how alterations in these processes are associated with liver disease, and evaluate potential therapeutic strategies using small molecules, natural products, or herb extracts that target these pathways. Through this analysis, we provide new insights into the versatility and multitargets of SREBPs as factors in the modulation of different physiological stages of liver disease, highlighting their potential targets for therapeutic treatment.https://www.mdpi.com/2227-9059/11/12/3280SREBPsNAFLDNASHfibrosishepatocellular carcinoma (HCC)lipogenesis |
| spellingShingle | Na Li Xiaodan Li Yifu Ding Xiao Liu Karin Diggle Tatiana Kisseleva David A. Brenner SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies Biomedicines SREBPs NAFLD NASH fibrosis hepatocellular carcinoma (HCC) lipogenesis |
| title | SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies |
| title_full | SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies |
| title_fullStr | SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies |
| title_full_unstemmed | SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies |
| title_short | SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies |
| title_sort | srebp regulation of lipid metabolism in liver disease and therapeutic strategies |
| topic | SREBPs NAFLD NASH fibrosis hepatocellular carcinoma (HCC) lipogenesis |
| url | https://www.mdpi.com/2227-9059/11/12/3280 |
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