Transcriptional profiling demonstrates altered characteristics of CD8+ cytotoxic T‐cells and regulatory T‐cells in TP53‐mutated acute myeloid leukemia

Transcriptional profiling demonstrates altered characteristics of CD8+ cytotoxic T‐cells and regulatory T‐cells in TP53‐mutated acute myeloid leukemia

Abstract Background Acute myeloid leukemia (AML) patients have limited effect from T‐cell‐based therapies, such as PD‐1 and CTLA‐4 blockade. However, recent data indicate that AML patients with TP53 mutation have higher immune infiltration and other immunomodulatory therapies could thus potentially...

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Bibliographic Details
Main Authors: Milad Abolhalaj, Viktor Sincic, Henrik Lilljebjörn, Carl Sandén, Alar Aab, Karin Hägerbrand, Peter Ellmark, Carl A. K. Borrebaeck, Thoas Fioretos, Kristina Lundberg
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Cancer Medicine
Subjects:
acute myeloid leukemia
immunotherapy
RNA‐sequencing
T‐cells
TP53
Online Access:https://doi.org/10.1002/cam4.4661

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