Is Echocardiography Mandatory for All Streptococcus gallolyticus Subsp. pasteurianus Bacteremia?
Worapong Nasomsong, Vasin Vasikasin, Jantima Traipattanakul, Dhitiwat Changpradub Division of Infectious Diseases, Department of Internal Medicine, Phramongkutklao Hospital, Bangkok, ThailandCorrespondence: Dhitiwat ChangpradubDivision of Infectious Disease, Department of Internal Medicine, Phramong...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-07-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/is-echocardiography-mandatory-for-all-streptococcus-gallolyticus-subsp-peer-reviewed-article-IDR |
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| author | Nasomsong W Vasikasin V Traipattanakul J Changpradub D |
| author_facet | Nasomsong W Vasikasin V Traipattanakul J Changpradub D |
| author_sort | Nasomsong W |
| collection | DOAJ |
| description | Worapong Nasomsong, Vasin Vasikasin, Jantima Traipattanakul, Dhitiwat Changpradub Division of Infectious Diseases, Department of Internal Medicine, Phramongkutklao Hospital, Bangkok, ThailandCorrespondence: Dhitiwat ChangpradubDivision of Infectious Disease, Department of Internal Medicine, Phramongkutklao Hospital and College of Medicine, 317 Ratchavithi Road, Ratchadhevi, Bangkok 10400, ThailandTel +6627639337Email dhitiwat@yahoo.comBackground: Streptococcus gallolyticus, formerly known as one of the Streptococcus bovis group, is frequently associated with endocarditis. Current guidelines recommended diagnostic work-up for endocarditis among patients with S. gallolyticus bacteremia. However, S. gallolyticus subsp. pasteurianus, was found to be associated with neonatal sepsis and liver diseases and is less commonly associated with endocarditis compared with S. gallolyticus subsp. gallolyticus. Our study aimed to identify the risk factors for S. gallolyticus subsp. pasteurianus endocarditis to help select the patients for echocardiography.Methods: In this retrospective cohort study, medical records from all adult patients with S. gallolyticus subsp. pasteurianus isolated from blood cultures at Phramongkutklao Hospital from 2009 to 2015 were reviewed. Patients who had mixed bacteremia or missing records were excluded from the study.Results: During the study period, S. gallolyticus subsp. pasteurianus was isolated among 106 individuals. Mean age was 66.9± 15.6 years. Most patients (61.3%) were male, with cirrhosis as the most common underlying diseases (46.2%), followed by malignancy and chronic kidney disease. Most common manifestations included primary bacteremia (44.3%), followed by spontaneous bacterial peritonitis (23.6%). Infective endocarditis was found among 9 patients. No patients with cirrhosis or single blood specimen of bacteremia had endocarditis (RR 0; p-value 0.003, and RR 1.35; p-value 0.079). The common complications associated with endocarditis were acute respiratory failure (RR 4.32; p-value 0.05), whereas acute kidney injury was a protective factor (RR 0; p-value 0.01). Among 76 patients who had records of 2-year follow-up, no new diagnosis of endocarditis or malignancy was observed.Conclusion: Among patients with S. gallolyticus subsp. pasteurianus bacteremia, echocardiography might not be needed among patients with cirrhosis and without sustained bacteremia.Keywords: Streptococcus gallolyticus subspecies pasteurianus, endocarditis, cirrhosis, bacteremia |
| first_indexed | 2024-12-11T03:21:19Z |
| format | Article |
| id | doaj.art-20b5edfe73ff4d5e8c583dea4d80794a |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-11T03:21:19Z |
| publishDate | 2020-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-20b5edfe73ff4d5e8c583dea4d80794a2022-12-22T01:22:37ZengDove Medical PressInfection and Drug Resistance1178-69732020-07-01Volume 132425243255453Is Echocardiography Mandatory for All Streptococcus gallolyticus Subsp. pasteurianus Bacteremia?Nasomsong WVasikasin VTraipattanakul JChangpradub DWorapong Nasomsong, Vasin Vasikasin, Jantima Traipattanakul, Dhitiwat Changpradub Division of Infectious Diseases, Department of Internal Medicine, Phramongkutklao Hospital, Bangkok, ThailandCorrespondence: Dhitiwat ChangpradubDivision of Infectious Disease, Department of Internal Medicine, Phramongkutklao Hospital and College of Medicine, 317 Ratchavithi Road, Ratchadhevi, Bangkok 10400, ThailandTel +6627639337Email dhitiwat@yahoo.comBackground: Streptococcus gallolyticus, formerly known as one of the Streptococcus bovis group, is frequently associated with endocarditis. Current guidelines recommended diagnostic work-up for endocarditis among patients with S. gallolyticus bacteremia. However, S. gallolyticus subsp. pasteurianus, was found to be associated with neonatal sepsis and liver diseases and is less commonly associated with endocarditis compared with S. gallolyticus subsp. gallolyticus. Our study aimed to identify the risk factors for S. gallolyticus subsp. pasteurianus endocarditis to help select the patients for echocardiography.Methods: In this retrospective cohort study, medical records from all adult patients with S. gallolyticus subsp. pasteurianus isolated from blood cultures at Phramongkutklao Hospital from 2009 to 2015 were reviewed. Patients who had mixed bacteremia or missing records were excluded from the study.Results: During the study period, S. gallolyticus subsp. pasteurianus was isolated among 106 individuals. Mean age was 66.9± 15.6 years. Most patients (61.3%) were male, with cirrhosis as the most common underlying diseases (46.2%), followed by malignancy and chronic kidney disease. Most common manifestations included primary bacteremia (44.3%), followed by spontaneous bacterial peritonitis (23.6%). Infective endocarditis was found among 9 patients. No patients with cirrhosis or single blood specimen of bacteremia had endocarditis (RR 0; p-value 0.003, and RR 1.35; p-value 0.079). The common complications associated with endocarditis were acute respiratory failure (RR 4.32; p-value 0.05), whereas acute kidney injury was a protective factor (RR 0; p-value 0.01). Among 76 patients who had records of 2-year follow-up, no new diagnosis of endocarditis or malignancy was observed.Conclusion: Among patients with S. gallolyticus subsp. pasteurianus bacteremia, echocardiography might not be needed among patients with cirrhosis and without sustained bacteremia.Keywords: Streptococcus gallolyticus subspecies pasteurianus, endocarditis, cirrhosis, bacteremiahttps://www.dovepress.com/is-echocardiography-mandatory-for-all-streptococcus-gallolyticus-subsp-peer-reviewed-article-IDRstreptococcus gallolyticus subspecies pasteurianusendocarditiscirrhosisbacteremia |
| spellingShingle | Nasomsong W Vasikasin V Traipattanakul J Changpradub D Is Echocardiography Mandatory for All Streptococcus gallolyticus Subsp. pasteurianus Bacteremia? Infection and Drug Resistance streptococcus gallolyticus subspecies pasteurianus endocarditis cirrhosis bacteremia |
| title | Is Echocardiography Mandatory for All Streptococcus gallolyticus Subsp. pasteurianus Bacteremia? |
| title_full | Is Echocardiography Mandatory for All Streptococcus gallolyticus Subsp. pasteurianus Bacteremia? |
| title_fullStr | Is Echocardiography Mandatory for All Streptococcus gallolyticus Subsp. pasteurianus Bacteremia? |
| title_full_unstemmed | Is Echocardiography Mandatory for All Streptococcus gallolyticus Subsp. pasteurianus Bacteremia? |
| title_short | Is Echocardiography Mandatory for All Streptococcus gallolyticus Subsp. pasteurianus Bacteremia? |
| title_sort | is echocardiography mandatory for all streptococcus gallolyticus subsp pasteurianus bacteremia |
| topic | streptococcus gallolyticus subspecies pasteurianus endocarditis cirrhosis bacteremia |
| url | https://www.dovepress.com/is-echocardiography-mandatory-for-all-streptococcus-gallolyticus-subsp-peer-reviewed-article-IDR |
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