Development of the foregut and the formation of the trachea and esophagus in rat embryos. A symphony of confusion
Introduction: During embryonic development, the trachea emerges from an area of the foregut, which is often referred to as “anterior” or “common” foregut tube or simply foregut. To explain this process of differentiation, four competing models exist to date. The outgrowth and watershed models propos...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1092753/full |
| _version_ | 1811170395394408448 |
|---|---|
| author | Marco Ginzel Nana Huber Leopold Bauer Dietrich Kluth Roman Metzger |
| author_facet | Marco Ginzel Nana Huber Leopold Bauer Dietrich Kluth Roman Metzger |
| author_sort | Marco Ginzel |
| collection | DOAJ |
| description | Introduction: During embryonic development, the trachea emerges from an area of the foregut, which is often referred to as “anterior” or “common” foregut tube or simply foregut. To explain this process of differentiation, four competing models exist to date. The outgrowth and watershed models propose a foregut that remains constant in length. In the outgrowth model, the trachea buds off and elongates from the foregut, while in the watershed model, a mesenchymal wedge splits the growing foregut into the trachea and esophagus. In contrast, the septation model proposes a cranial splitting and thus a shortening of the “common” foregut tube into the trachea and esophagus by an emerging septum. Finally, the splitting and extension model describes an interaction of cranial splitting of the foregut and simultaneous caudal tracheal and esophageal growth.Methods: Here we examine the development of the undifferentiated foregut by micro computed tomography, which allows precise measurements.Results: Our results show that this area of the foregut transforms into the larynx, a process, which is independent from tracheal and esophageal development.Discussion: These observations are only consistent with the outgrowth model. |
| first_indexed | 2024-04-10T16:56:03Z |
| format | Article |
| id | doaj.art-20b62873ebc64615b6cabe2bf1ab1266 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-10T16:56:03Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-20b62873ebc64615b6cabe2bf1ab12662023-02-07T05:36:06ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-02-011110.3389/fcell.2023.10927531092753Development of the foregut and the formation of the trachea and esophagus in rat embryos. A symphony of confusionMarco Ginzel0Nana Huber1Leopold Bauer2Dietrich Kluth3Roman Metzger4Department of Pediatric and Adolescent Surgery, Paracelsus Medical University Hospital, Salzburg, AustriaDepartment of Pediatric and Adolescent Surgery, Paracelsus Medical University Hospital, Salzburg, AustriaDepartment of Pediatric and Adolescent Surgery, Paracelsus Medical University Hospital, Salzburg, AustriaDepartment of Pediatric Surgery, University Hospital Leipzig, Leipzig, GermanyDepartment of Pediatric and Adolescent Surgery, Paracelsus Medical University Hospital, Salzburg, AustriaIntroduction: During embryonic development, the trachea emerges from an area of the foregut, which is often referred to as “anterior” or “common” foregut tube or simply foregut. To explain this process of differentiation, four competing models exist to date. The outgrowth and watershed models propose a foregut that remains constant in length. In the outgrowth model, the trachea buds off and elongates from the foregut, while in the watershed model, a mesenchymal wedge splits the growing foregut into the trachea and esophagus. In contrast, the septation model proposes a cranial splitting and thus a shortening of the “common” foregut tube into the trachea and esophagus by an emerging septum. Finally, the splitting and extension model describes an interaction of cranial splitting of the foregut and simultaneous caudal tracheal and esophageal growth.Methods: Here we examine the development of the undifferentiated foregut by micro computed tomography, which allows precise measurements.Results: Our results show that this area of the foregut transforms into the larynx, a process, which is independent from tracheal and esophageal development.Discussion: These observations are only consistent with the outgrowth model.https://www.frontiersin.org/articles/10.3389/fcell.2023.1092753/fullforegut developmentmicro computed tomographyμCTembryologytracheal developmentesophageal development |
| spellingShingle | Marco Ginzel Nana Huber Leopold Bauer Dietrich Kluth Roman Metzger Development of the foregut and the formation of the trachea and esophagus in rat embryos. A symphony of confusion Frontiers in Cell and Developmental Biology foregut development micro computed tomography μCT embryology tracheal development esophageal development |
| title | Development of the foregut and the formation of the trachea and esophagus in rat embryos. A symphony of confusion |
| title_full | Development of the foregut and the formation of the trachea and esophagus in rat embryos. A symphony of confusion |
| title_fullStr | Development of the foregut and the formation of the trachea and esophagus in rat embryos. A symphony of confusion |
| title_full_unstemmed | Development of the foregut and the formation of the trachea and esophagus in rat embryos. A symphony of confusion |
| title_short | Development of the foregut and the formation of the trachea and esophagus in rat embryos. A symphony of confusion |
| title_sort | development of the foregut and the formation of the trachea and esophagus in rat embryos a symphony of confusion |
| topic | foregut development micro computed tomography μCT embryology tracheal development esophageal development |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1092753/full |
| work_keys_str_mv | AT marcoginzel developmentoftheforegutandtheformationofthetracheaandesophagusinratembryosasymphonyofconfusion AT nanahuber developmentoftheforegutandtheformationofthetracheaandesophagusinratembryosasymphonyofconfusion AT leopoldbauer developmentoftheforegutandtheformationofthetracheaandesophagusinratembryosasymphonyofconfusion AT dietrichkluth developmentoftheforegutandtheformationofthetracheaandesophagusinratembryosasymphonyofconfusion AT romanmetzger developmentoftheforegutandtheformationofthetracheaandesophagusinratembryosasymphonyofconfusion |