Phytochemical Profiling of <i>Lavandula coronopifolia</i> Poir. Aerial Parts Extract and Its Larvicidal, Antibacterial, and Antibiofilm Activity Against <i>Pseudomonas aeruginosa</i>
Infections associated with the emergence of multidrug resistance and mosquito-borne diseases have resulted in serious crises associated with high mortality and left behind a huge socioeconomic burden. The chemical investigation of <i>Lavandula</i><i>coronopifolia</i> aerial p...
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MDPI AG
2021-03-01
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| author | Mahmoud Emam Doaa R. Abdel-Haleem Maha M. Salem Lina Jamil M. Abdel-Hafez Rasha R. Abdel Latif Shaimaa Mahmoud Farag Mansour Sobeh Mohamed A. El Raey |
| author_facet | Mahmoud Emam Doaa R. Abdel-Haleem Maha M. Salem Lina Jamil M. Abdel-Hafez Rasha R. Abdel Latif Shaimaa Mahmoud Farag Mansour Sobeh Mohamed A. El Raey |
| author_sort | Mahmoud Emam |
| collection | DOAJ |
| description | Infections associated with the emergence of multidrug resistance and mosquito-borne diseases have resulted in serious crises associated with high mortality and left behind a huge socioeconomic burden. The chemical investigation of <i>Lavandula</i><i>coronopifolia</i> aerial parts extract using HPLC–MS/MS led to the tentative identification of 46 compounds belonging to phenolic acids, flavonoids and their glycosides, and biflavonoids. The extract displayed larvicidal activity against <i>Culex pipiens</i> larvae (LC<sub>50</sub> = 29.08 µg/mL at 72 h). It significantly inhibited cytochrome P-450 monooxygenase (CYP450), acetylcholinesterase (AChE), and carboxylesterase (CarE) enzymes with the comparable pattern to the control group, which could explain the mode of larvae toxification. The extract also inhibited the biofilm formation of <i>Pseudomonas aeruginosa</i> by 17–38% at different Minimum Inhibitory Concentrations (MICs) (0.5–0.125 mg/mL) while the activity was doubled when combined with ciprofloxacin (ratio = 1:1 <i>v</i>:<i>v</i>). In conclusion, the wild plant, <i>L.</i><i>coronopifolia,</i> can be considered a promising natural source against resistant bacteria and infectious carriers. |
| first_indexed | 2024-03-10T13:05:30Z |
| format | Article |
| id | doaj.art-20ba50a25eae46bda9d5aebe4ec04fbf |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T13:05:30Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-20ba50a25eae46bda9d5aebe4ec04fbf2023-11-21T11:07:19ZengMDPI AGMolecules1420-30492021-03-01266171010.3390/molecules26061710Phytochemical Profiling of <i>Lavandula coronopifolia</i> Poir. Aerial Parts Extract and Its Larvicidal, Antibacterial, and Antibiofilm Activity Against <i>Pseudomonas aeruginosa</i>Mahmoud Emam0Doaa R. Abdel-Haleem1Maha M. Salem2Lina Jamil M. Abdel-Hafez3Rasha R. Abdel Latif4Shaimaa Mahmoud Farag5Mansour Sobeh6Mohamed A. El Raey7College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaDepartment of entomology, Faculty of Science, Ain Shams University, Abbasia, Cairo 11566, EgyptPhytochemistry and Plant Systematics Department, National Research Centre, Dokki, Giza 12622, EgyptDepartment of Microbiology and Immunology, Faculty of Pharmacy, October 6 University, 6th October City, Giza 12585, EgyptPhytochemistry and Plant Systematics Department, National Research Centre, Dokki, Giza 12622, EgyptDepartment of entomology, Faculty of Science, Ain Shams University, Abbasia, Cairo 11566, EgyptAgroBioSciences Research Division, Mohammed VI Polytechnic University, Lot 660–Hay MoulayRachid, 43150 Ben-Guerir, MoroccoPhytochemistry and Plant Systematics Department, National Research Centre, Dokki, Giza 12622, EgyptInfections associated with the emergence of multidrug resistance and mosquito-borne diseases have resulted in serious crises associated with high mortality and left behind a huge socioeconomic burden. The chemical investigation of <i>Lavandula</i><i>coronopifolia</i> aerial parts extract using HPLC–MS/MS led to the tentative identification of 46 compounds belonging to phenolic acids, flavonoids and their glycosides, and biflavonoids. The extract displayed larvicidal activity against <i>Culex pipiens</i> larvae (LC<sub>50</sub> = 29.08 µg/mL at 72 h). It significantly inhibited cytochrome P-450 monooxygenase (CYP450), acetylcholinesterase (AChE), and carboxylesterase (CarE) enzymes with the comparable pattern to the control group, which could explain the mode of larvae toxification. The extract also inhibited the biofilm formation of <i>Pseudomonas aeruginosa</i> by 17–38% at different Minimum Inhibitory Concentrations (MICs) (0.5–0.125 mg/mL) while the activity was doubled when combined with ciprofloxacin (ratio = 1:1 <i>v</i>:<i>v</i>). In conclusion, the wild plant, <i>L.</i><i>coronopifolia,</i> can be considered a promising natural source against resistant bacteria and infectious carriers.https://www.mdpi.com/1420-3049/26/6/1710<i>Lavandula coronopifolia</i><i>Culex pipiens</i>larvicidalantibiofilm formationLC-MS/MSmolecular networking |
| spellingShingle | Mahmoud Emam Doaa R. Abdel-Haleem Maha M. Salem Lina Jamil M. Abdel-Hafez Rasha R. Abdel Latif Shaimaa Mahmoud Farag Mansour Sobeh Mohamed A. El Raey Phytochemical Profiling of <i>Lavandula coronopifolia</i> Poir. Aerial Parts Extract and Its Larvicidal, Antibacterial, and Antibiofilm Activity Against <i>Pseudomonas aeruginosa</i> Molecules <i>Lavandula coronopifolia</i> <i>Culex pipiens</i> larvicidal antibiofilm formation LC-MS/MS molecular networking |
| title | Phytochemical Profiling of <i>Lavandula coronopifolia</i> Poir. Aerial Parts Extract and Its Larvicidal, Antibacterial, and Antibiofilm Activity Against <i>Pseudomonas aeruginosa</i> |
| title_full | Phytochemical Profiling of <i>Lavandula coronopifolia</i> Poir. Aerial Parts Extract and Its Larvicidal, Antibacterial, and Antibiofilm Activity Against <i>Pseudomonas aeruginosa</i> |
| title_fullStr | Phytochemical Profiling of <i>Lavandula coronopifolia</i> Poir. Aerial Parts Extract and Its Larvicidal, Antibacterial, and Antibiofilm Activity Against <i>Pseudomonas aeruginosa</i> |
| title_full_unstemmed | Phytochemical Profiling of <i>Lavandula coronopifolia</i> Poir. Aerial Parts Extract and Its Larvicidal, Antibacterial, and Antibiofilm Activity Against <i>Pseudomonas aeruginosa</i> |
| title_short | Phytochemical Profiling of <i>Lavandula coronopifolia</i> Poir. Aerial Parts Extract and Its Larvicidal, Antibacterial, and Antibiofilm Activity Against <i>Pseudomonas aeruginosa</i> |
| title_sort | phytochemical profiling of i lavandula coronopifolia i poir aerial parts extract and its larvicidal antibacterial and antibiofilm activity against i pseudomonas aeruginosa i |
| topic | <i>Lavandula coronopifolia</i> <i>Culex pipiens</i> larvicidal antibiofilm formation LC-MS/MS molecular networking |
| url | https://www.mdpi.com/1420-3049/26/6/1710 |
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