CLINICAL AND LABORATORY CHARACTERISTICS OF SARS-COV-2 INFECTION IN CHILDREN AND ADOLESCENTS

ABSTRACT Objective: To present the current evidence on clinical and laboratory characteristics of infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during childhood and adolescence. Data source: This is a narrative review conducted in the databases: Medical Literature Ana...

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Main Authors: Marlos Melo Martins, Arnaldo Prata-Barbosa, Maria Clara de Magalhães-Barbosa, Antonio José Ledo Alves da Cunha
Format: Article
Language:English
Published: Sociedade de Pediatria de São Paulo 2020-11-01
Series:Revista Paulista de Pediatria
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822021000100507&tlng=pt
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author Marlos Melo Martins
Arnaldo Prata-Barbosa
Maria Clara de Magalhães-Barbosa
Antonio José Ledo Alves da Cunha
author_facet Marlos Melo Martins
Arnaldo Prata-Barbosa
Maria Clara de Magalhães-Barbosa
Antonio José Ledo Alves da Cunha
author_sort Marlos Melo Martins
collection DOAJ
description ABSTRACT Objective: To present the current evidence on clinical and laboratory characteristics of infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during childhood and adolescence. Data source: This is a narrative review conducted in the databases: Medical Literature Analysis and Retrieval System Online (MEDLINE/PubMed), Latin American and Caribbean Health Sciences Literature in the Virtual Health Library (LILACS/VHL), Scopus, Web of Science, Cochrane Library, portal of the Coordination for the Improvement of Higher Education Personnel (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES), Scientific Electronic Library Online (SciELO), ScienceDirect, and Cumulative Index to Nursing and Allied Health Literature (CINAHL). The terms used were SARS-CoV-2, COVID-19, novel coronavirus, child, newborn, and adolescent. Data synthesis: Unlike adults, most children infected by SARS-CoV-2 have mild or asymptomatic clinical presentations. Symptomatic children mainly have low fever and cough, with some associated gastrointestinal symptoms. Severe cases are rare and occur especially in infants under one year of age. Detection of viral particles in feces seems to be more persistent in children and can be used as a tool for diagnosis and control of the quarantine period. Different from adults, children can present distinct inflammatory responses, as has happened in new cases of Kawasaki-like syndrome associated with SARS-CoV-2 infection. Conclusions: Most children have asymptomatic or mild presentations, with a prevalence of fever, cough, and gastrointestinal symptoms. New cases with different systemic inflammatory reactions in children have been reported, with clinical manifestations distinct from those typically found in adults.
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spelling doaj.art-20ba8bc0007d4cea8af51db9f89e30db2022-12-21T23:40:32ZengSociedade de Pediatria de São PauloRevista Paulista de Pediatria1984-04622020-11-013910.1590/1984-0462/2021/39/2020231CLINICAL AND LABORATORY CHARACTERISTICS OF SARS-COV-2 INFECTION IN CHILDREN AND ADOLESCENTSMarlos Melo Martinshttps://orcid.org/0000-0002-5511-4764Arnaldo Prata-Barbosahttps://orcid.org/0000-0002-4726-9782Maria Clara de Magalhães-Barbosahttps://orcid.org/0000-0003-0959-0775Antonio José Ledo Alves da Cunhahttps://orcid.org/0000-0003-3592-1849ABSTRACT Objective: To present the current evidence on clinical and laboratory characteristics of infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during childhood and adolescence. Data source: This is a narrative review conducted in the databases: Medical Literature Analysis and Retrieval System Online (MEDLINE/PubMed), Latin American and Caribbean Health Sciences Literature in the Virtual Health Library (LILACS/VHL), Scopus, Web of Science, Cochrane Library, portal of the Coordination for the Improvement of Higher Education Personnel (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES), Scientific Electronic Library Online (SciELO), ScienceDirect, and Cumulative Index to Nursing and Allied Health Literature (CINAHL). The terms used were SARS-CoV-2, COVID-19, novel coronavirus, child, newborn, and adolescent. Data synthesis: Unlike adults, most children infected by SARS-CoV-2 have mild or asymptomatic clinical presentations. Symptomatic children mainly have low fever and cough, with some associated gastrointestinal symptoms. Severe cases are rare and occur especially in infants under one year of age. Detection of viral particles in feces seems to be more persistent in children and can be used as a tool for diagnosis and control of the quarantine period. Different from adults, children can present distinct inflammatory responses, as has happened in new cases of Kawasaki-like syndrome associated with SARS-CoV-2 infection. Conclusions: Most children have asymptomatic or mild presentations, with a prevalence of fever, cough, and gastrointestinal symptoms. New cases with different systemic inflammatory reactions in children have been reported, with clinical manifestations distinct from those typically found in adults.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822021000100507&tlng=ptSARS-CoV-2COVID-19ChildInfant, newbornAdolescent
spellingShingle Marlos Melo Martins
Arnaldo Prata-Barbosa
Maria Clara de Magalhães-Barbosa
Antonio José Ledo Alves da Cunha
CLINICAL AND LABORATORY CHARACTERISTICS OF SARS-COV-2 INFECTION IN CHILDREN AND ADOLESCENTS
Revista Paulista de Pediatria
SARS-CoV-2
COVID-19
Child
Infant, newborn
Adolescent
title CLINICAL AND LABORATORY CHARACTERISTICS OF SARS-COV-2 INFECTION IN CHILDREN AND ADOLESCENTS
title_full CLINICAL AND LABORATORY CHARACTERISTICS OF SARS-COV-2 INFECTION IN CHILDREN AND ADOLESCENTS
title_fullStr CLINICAL AND LABORATORY CHARACTERISTICS OF SARS-COV-2 INFECTION IN CHILDREN AND ADOLESCENTS
title_full_unstemmed CLINICAL AND LABORATORY CHARACTERISTICS OF SARS-COV-2 INFECTION IN CHILDREN AND ADOLESCENTS
title_short CLINICAL AND LABORATORY CHARACTERISTICS OF SARS-COV-2 INFECTION IN CHILDREN AND ADOLESCENTS
title_sort clinical and laboratory characteristics of sars cov 2 infection in children and adolescents
topic SARS-CoV-2
COVID-19
Child
Infant, newborn
Adolescent
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822021000100507&tlng=pt
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