| Summary: | Tandem repetitions in protein sequence and structure is a fascinatingsubject of research which has been a focus of study since the late 1990's.In this survey we give an overviewon the multi-faceted aspects of research on protein tandem repeats textcolor{red}{(PTR for short)}, including prediction algorithms, databases,early classification efforts, mechanisms of PTR formation and evolution, and synthetic PTR design.We also touch on the rather open issue of the relationship between PTRand flexibility (or disorder) in proteins.Detection of PTR either from protein sequence or structure data is challenging due to inherent high (biological) signal-to-noise ratio that is a key feature of this problem.As early in silico analytic tools have been key enablers for starting this field of study, we expect that current and future algorithmic and statistical breakthroughs willhave a high impact on the investigations of the biological role of PTR.
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