Tandem Repeats in Proteins : Prediction Algorithms and Biological Role
Tandem repetitions in protein sequence and structure is a fascinatingsubject of research which has been a focus of study since the late 1990's.In this survey we give an overviewon the multi-faceted aspects of research on protein tandem repeats textcolor{red}{(PTR for short)}, including predic...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-09-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00143/full |
| _version_ | 1818511301381455872 |
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| author | Marco ePellegrini |
| author_facet | Marco ePellegrini |
| author_sort | Marco ePellegrini |
| collection | DOAJ |
| description | Tandem repetitions in protein sequence and structure is a fascinatingsubject of research which has been a focus of study since the late 1990's.In this survey we give an overviewon the multi-faceted aspects of research on protein tandem repeats textcolor{red}{(PTR for short)}, including prediction algorithms, databases,early classification efforts, mechanisms of PTR formation and evolution, and synthetic PTR design.We also touch on the rather open issue of the relationship between PTRand flexibility (or disorder) in proteins.Detection of PTR either from protein sequence or structure data is challenging due to inherent high (biological) signal-to-noise ratio that is a key feature of this problem.As early in silico analytic tools have been key enablers for starting this field of study, we expect that current and future algorithmic and statistical breakthroughs willhave a high impact on the investigations of the biological role of PTR. |
| first_indexed | 2024-12-10T23:31:28Z |
| format | Article |
| id | doaj.art-20be29f2d6a7402eabb1ad455d1b5b45 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-10T23:31:28Z |
| publishDate | 2015-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-20be29f2d6a7402eabb1ad455d1b5b452022-12-22T01:29:22ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852015-09-01310.3389/fbioe.2015.00143155885Tandem Repeats in Proteins : Prediction Algorithms and Biological RoleMarco ePellegrini0Consiglio Nazionale delle RicercheTandem repetitions in protein sequence and structure is a fascinatingsubject of research which has been a focus of study since the late 1990's.In this survey we give an overviewon the multi-faceted aspects of research on protein tandem repeats textcolor{red}{(PTR for short)}, including prediction algorithms, databases,early classification efforts, mechanisms of PTR formation and evolution, and synthetic PTR design.We also touch on the rather open issue of the relationship between PTRand flexibility (or disorder) in proteins.Detection of PTR either from protein sequence or structure data is challenging due to inherent high (biological) signal-to-noise ratio that is a key feature of this problem.As early in silico analytic tools have been key enablers for starting this field of study, we expect that current and future algorithmic and statistical breakthroughs willhave a high impact on the investigations of the biological role of PTR.http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00143/fullProteinstandem repeatsBiological significanceProtein TR Detection AlgorithmsProtein TR properties |
| spellingShingle | Marco ePellegrini Tandem Repeats in Proteins : Prediction Algorithms and Biological Role Frontiers in Bioengineering and Biotechnology Proteins tandem repeats Biological significance Protein TR Detection Algorithms Protein TR properties |
| title | Tandem Repeats in Proteins : Prediction Algorithms and Biological Role |
| title_full | Tandem Repeats in Proteins : Prediction Algorithms and Biological Role |
| title_fullStr | Tandem Repeats in Proteins : Prediction Algorithms and Biological Role |
| title_full_unstemmed | Tandem Repeats in Proteins : Prediction Algorithms and Biological Role |
| title_short | Tandem Repeats in Proteins : Prediction Algorithms and Biological Role |
| title_sort | tandem repeats in proteins prediction algorithms and biological role |
| topic | Proteins tandem repeats Biological significance Protein TR Detection Algorithms Protein TR properties |
| url | http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00143/full |
| work_keys_str_mv | AT marcoepellegrini tandemrepeatsinproteinspredictionalgorithmsandbiologicalrole |