Secondary Metabolites from Coral-Associated Fungi: Source, Chemistry and Bioactivities
Our study of the secondary metabolites of coral-associated fungi produced a valuable and extra-large chemical database. Many of them exhibit strong biological activity and can be used for promising drug lead compounds. Serving as an epitome of the most promising compounds, which take the ultra-new s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/8/10/1043 |
| _version_ | 1797472284067233792 |
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| author | Ying Chen Xiaoyan Pang Yanchun He Xiuping Lin Xuefeng Zhou Yonghong Liu Bin Yang |
| author_facet | Ying Chen Xiaoyan Pang Yanchun He Xiuping Lin Xuefeng Zhou Yonghong Liu Bin Yang |
| author_sort | Ying Chen |
| collection | DOAJ |
| description | Our study of the secondary metabolites of coral-associated fungi produced a valuable and extra-large chemical database. Many of them exhibit strong biological activity and can be used for promising drug lead compounds. Serving as an epitome of the most promising compounds, which take the ultra-new skeletons and/or remarkable bioactivities, this review presents an overview of new compounds and bioactive compounds isolated from coral-associated fungi, covering the literature from 2010 to 2021. Its scope included 423 metabolites, focusing on the bioactivity and structure diversity of these compounds. According to structure, these compounds can be roughly classified as terpenes, alkaloids, peptides, aromatics, lactones, steroids, and other compounds. Some of them described in this review possess a wide range of bioactivities, such as anticancer, antimicrobial, antifouling, and other activities. This review aims to provide some significant chemical and/or biological enlightenment for the study of marine natural products and marine drug development in the future. |
| first_indexed | 2024-03-09T19:59:41Z |
| format | Article |
| id | doaj.art-20bf2c7aab17404e94891f5b2d0940fa |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T19:59:41Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-20bf2c7aab17404e94891f5b2d0940fa2023-11-24T00:47:06ZengMDPI AGJournal of Fungi2309-608X2022-10-01810104310.3390/jof8101043Secondary Metabolites from Coral-Associated Fungi: Source, Chemistry and BioactivitiesYing Chen0Xiaoyan Pang1Yanchun He2Xiuping Lin3Xuefeng Zhou4Yonghong Liu5Bin Yang6CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaOur study of the secondary metabolites of coral-associated fungi produced a valuable and extra-large chemical database. Many of them exhibit strong biological activity and can be used for promising drug lead compounds. Serving as an epitome of the most promising compounds, which take the ultra-new skeletons and/or remarkable bioactivities, this review presents an overview of new compounds and bioactive compounds isolated from coral-associated fungi, covering the literature from 2010 to 2021. Its scope included 423 metabolites, focusing on the bioactivity and structure diversity of these compounds. According to structure, these compounds can be roughly classified as terpenes, alkaloids, peptides, aromatics, lactones, steroids, and other compounds. Some of them described in this review possess a wide range of bioactivities, such as anticancer, antimicrobial, antifouling, and other activities. This review aims to provide some significant chemical and/or biological enlightenment for the study of marine natural products and marine drug development in the future.https://www.mdpi.com/2309-608X/8/10/1043coral-derived fungusbiological activitiesnatural products |
| spellingShingle | Ying Chen Xiaoyan Pang Yanchun He Xiuping Lin Xuefeng Zhou Yonghong Liu Bin Yang Secondary Metabolites from Coral-Associated Fungi: Source, Chemistry and Bioactivities Journal of Fungi coral-derived fungus biological activities natural products |
| title | Secondary Metabolites from Coral-Associated Fungi: Source, Chemistry and Bioactivities |
| title_full | Secondary Metabolites from Coral-Associated Fungi: Source, Chemistry and Bioactivities |
| title_fullStr | Secondary Metabolites from Coral-Associated Fungi: Source, Chemistry and Bioactivities |
| title_full_unstemmed | Secondary Metabolites from Coral-Associated Fungi: Source, Chemistry and Bioactivities |
| title_short | Secondary Metabolites from Coral-Associated Fungi: Source, Chemistry and Bioactivities |
| title_sort | secondary metabolites from coral associated fungi source chemistry and bioactivities |
| topic | coral-derived fungus biological activities natural products |
| url | https://www.mdpi.com/2309-608X/8/10/1043 |
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