Long Noncoding RNA Mediated Regulation in Human Embryogenesis, Pluripotency, and Reproduction
Long noncoding RNAs (lncRNAs), a class of noncoding RNAs with more than 200 bp in length, are produced by pervasive transcription in mammalian genomes and regulate gene expression through various action mechanisms. Accumulating data indicate that lncRNAs mediate essential biological functions in hum...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2022-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2022/8051717 |
| _version_ | 1798024789796847616 |
|---|---|
| author | Lei Liu Fang Fang |
| author_facet | Lei Liu Fang Fang |
| author_sort | Lei Liu |
| collection | DOAJ |
| description | Long noncoding RNAs (lncRNAs), a class of noncoding RNAs with more than 200 bp in length, are produced by pervasive transcription in mammalian genomes and regulate gene expression through various action mechanisms. Accumulating data indicate that lncRNAs mediate essential biological functions in human development, including early embryogenesis, induction of pluripotency, and germ cell development. Comprehensive analysis of sequencing data highlights that lncRNAs are expressed in a stage-specific and human/primate-specific pattern during early human development. They contribute to cell fate determination through interacting with almost all classes of cellular biomolecules, including proteins, DNA, mRNAs, and microRNAs. Furthermore, the expression of a few of lncRNAs is highly associated with the pathogenesis and progression of many reproductive diseases, suggesting that they could serve as candidate biomarkers for diagnosis or novel targets for treatment. Here, we review research on lncRNAs and their roles in embryogenesis, pluripotency, and reproduction. We aim to identify the underlying molecular mechanisms essential for human development and provide novel insight into the causes and treatments of human reproductive diseases. |
| first_indexed | 2024-04-11T18:09:25Z |
| format | Article |
| id | doaj.art-20c151938c30487cae179ec09af6bc66 |
| institution | Directory Open Access Journal |
| issn | 1687-9678 |
| language | English |
| last_indexed | 2024-04-11T18:09:25Z |
| publishDate | 2022-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj.art-20c151938c30487cae179ec09af6bc662022-12-22T04:10:12ZengHindawi LimitedStem Cells International1687-96782022-01-01202210.1155/2022/8051717Long Noncoding RNA Mediated Regulation in Human Embryogenesis, Pluripotency, and ReproductionLei Liu0Fang Fang1The First Affiliated Hospital of USTCThe First Affiliated Hospital of USTCLong noncoding RNAs (lncRNAs), a class of noncoding RNAs with more than 200 bp in length, are produced by pervasive transcription in mammalian genomes and regulate gene expression through various action mechanisms. Accumulating data indicate that lncRNAs mediate essential biological functions in human development, including early embryogenesis, induction of pluripotency, and germ cell development. Comprehensive analysis of sequencing data highlights that lncRNAs are expressed in a stage-specific and human/primate-specific pattern during early human development. They contribute to cell fate determination through interacting with almost all classes of cellular biomolecules, including proteins, DNA, mRNAs, and microRNAs. Furthermore, the expression of a few of lncRNAs is highly associated with the pathogenesis and progression of many reproductive diseases, suggesting that they could serve as candidate biomarkers for diagnosis or novel targets for treatment. Here, we review research on lncRNAs and their roles in embryogenesis, pluripotency, and reproduction. We aim to identify the underlying molecular mechanisms essential for human development and provide novel insight into the causes and treatments of human reproductive diseases.http://dx.doi.org/10.1155/2022/8051717 |
| spellingShingle | Lei Liu Fang Fang Long Noncoding RNA Mediated Regulation in Human Embryogenesis, Pluripotency, and Reproduction Stem Cells International |
| title | Long Noncoding RNA Mediated Regulation in Human Embryogenesis, Pluripotency, and Reproduction |
| title_full | Long Noncoding RNA Mediated Regulation in Human Embryogenesis, Pluripotency, and Reproduction |
| title_fullStr | Long Noncoding RNA Mediated Regulation in Human Embryogenesis, Pluripotency, and Reproduction |
| title_full_unstemmed | Long Noncoding RNA Mediated Regulation in Human Embryogenesis, Pluripotency, and Reproduction |
| title_short | Long Noncoding RNA Mediated Regulation in Human Embryogenesis, Pluripotency, and Reproduction |
| title_sort | long noncoding rna mediated regulation in human embryogenesis pluripotency and reproduction |
| url | http://dx.doi.org/10.1155/2022/8051717 |
| work_keys_str_mv | AT leiliu longnoncodingrnamediatedregulationinhumanembryogenesispluripotencyandreproduction AT fangfang longnoncodingrnamediatedregulationinhumanembryogenesispluripotencyandreproduction |