Genetic polymorphisms in DNA base excision repair gene <it>XRCC1 </it>and the risk of squamous cell carcinoma of the head and neck
<p>Abstract</p> <p>Background</p> <p>The genes of base excision repair (BER) pathway have been extensively studied in the association with various human cancers. We performed a case-control study to test the association between two common single nucleotide polymorphisms...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-03-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Online Access: | http://www.jeccr.com/content/28/1/37 |
| _version_ | 1811317923240738816 |
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| author | Pietruszewska Wioletta Bielecka-Kowalska Anna Morawiec-Sztandera Alina Olszewski Jurek Rusin Pawel Przybylowska Karolina Kowalski Michal Mlynarski Wojciech Szemaraj Janusz Majsterek Ireneusz |
| author_facet | Pietruszewska Wioletta Bielecka-Kowalska Anna Morawiec-Sztandera Alina Olszewski Jurek Rusin Pawel Przybylowska Karolina Kowalski Michal Mlynarski Wojciech Szemaraj Janusz Majsterek Ireneusz |
| author_sort | Pietruszewska Wioletta |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The genes of base excision repair (BER) pathway have been extensively studied in the association with various human cancers. We performed a case-control study to test the association between two common single nucleotide polymorphisms (SNPs) of <it>XRCC1 </it>gene with human head and neck squamous cell carcinoma (HNSCC).</p> <p>Methods</p> <p>The genotype analysis of Arg194Trp and Arg399Gln gene polymorphisms for 92 HNSCC patients and 124 controls of cancer free subjects, in Polish population were performed using the PCR-based restriction fragment length polymorphism (PCR-RFLP) with endonuclease <it>Msp</it>I.</p> <p>Results</p> <p>No altered risk has been found individually for these SNPs, however haplotypes analysis showed high association with head and neck cancer. The highest frequency, according to wild-type of Arg194Arg and Arg399Arg genotypes, was identified for Arg194Trp-Arg399Arg haplotype (OR, 2.96; 95% CI, 1.01–8.80).</p> <p>Conclusion</p> <p>Finally, we identified the combined Arg194Trp-Arg399Arg genotype of base excision repair gene <it>XRCC1 </it>that was associated with HNSCC and may have an impact on identification of a high-risk cancer population.</p> |
| first_indexed | 2024-04-13T12:16:50Z |
| format | Article |
| id | doaj.art-20c25b048ef241cf98b1a0505f375eb2 |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-04-13T12:16:50Z |
| publishDate | 2009-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-20c25b048ef241cf98b1a0505f375eb22022-12-22T02:47:20ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662009-03-012813710.1186/1756-9966-28-37Genetic polymorphisms in DNA base excision repair gene <it>XRCC1 </it>and the risk of squamous cell carcinoma of the head and neckPietruszewska WiolettaBielecka-Kowalska AnnaMorawiec-Sztandera AlinaOlszewski JurekRusin PawelPrzybylowska KarolinaKowalski MichalMlynarski WojciechSzemaraj JanuszMajsterek Ireneusz<p>Abstract</p> <p>Background</p> <p>The genes of base excision repair (BER) pathway have been extensively studied in the association with various human cancers. We performed a case-control study to test the association between two common single nucleotide polymorphisms (SNPs) of <it>XRCC1 </it>gene with human head and neck squamous cell carcinoma (HNSCC).</p> <p>Methods</p> <p>The genotype analysis of Arg194Trp and Arg399Gln gene polymorphisms for 92 HNSCC patients and 124 controls of cancer free subjects, in Polish population were performed using the PCR-based restriction fragment length polymorphism (PCR-RFLP) with endonuclease <it>Msp</it>I.</p> <p>Results</p> <p>No altered risk has been found individually for these SNPs, however haplotypes analysis showed high association with head and neck cancer. The highest frequency, according to wild-type of Arg194Arg and Arg399Arg genotypes, was identified for Arg194Trp-Arg399Arg haplotype (OR, 2.96; 95% CI, 1.01–8.80).</p> <p>Conclusion</p> <p>Finally, we identified the combined Arg194Trp-Arg399Arg genotype of base excision repair gene <it>XRCC1 </it>that was associated with HNSCC and may have an impact on identification of a high-risk cancer population.</p>http://www.jeccr.com/content/28/1/37 |
| spellingShingle | Pietruszewska Wioletta Bielecka-Kowalska Anna Morawiec-Sztandera Alina Olszewski Jurek Rusin Pawel Przybylowska Karolina Kowalski Michal Mlynarski Wojciech Szemaraj Janusz Majsterek Ireneusz Genetic polymorphisms in DNA base excision repair gene <it>XRCC1 </it>and the risk of squamous cell carcinoma of the head and neck Journal of Experimental & Clinical Cancer Research |
| title | Genetic polymorphisms in DNA base excision repair gene <it>XRCC1 </it>and the risk of squamous cell carcinoma of the head and neck |
| title_full | Genetic polymorphisms in DNA base excision repair gene <it>XRCC1 </it>and the risk of squamous cell carcinoma of the head and neck |
| title_fullStr | Genetic polymorphisms in DNA base excision repair gene <it>XRCC1 </it>and the risk of squamous cell carcinoma of the head and neck |
| title_full_unstemmed | Genetic polymorphisms in DNA base excision repair gene <it>XRCC1 </it>and the risk of squamous cell carcinoma of the head and neck |
| title_short | Genetic polymorphisms in DNA base excision repair gene <it>XRCC1 </it>and the risk of squamous cell carcinoma of the head and neck |
| title_sort | genetic polymorphisms in dna base excision repair gene it xrcc1 it and the risk of squamous cell carcinoma of the head and neck |
| url | http://www.jeccr.com/content/28/1/37 |
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