ГЕПАТИТ ДЕЛЬТА: ЭТИОЛОГИЯ, КЛИНИКА, ДИАГНОСТИКА, ТЕРАПИЯ (ЛЕКЦИЯ ДЛЯ ПРАКТИЧЕСКИХ ВРАЧЕЙ)
A significant part of liver disease, once considered the result of infection by hepatitis B virus (HBV), are the result of infection HBV, and hepatitis delta virus (HDV). HDV is hepatotropic, defective RNA virus that requires obligatory HBV presence for its replication and the formation of infectiou...
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| Format: | Article |
| Language: | Russian |
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SINAPS LLC
2014-10-01
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| Series: | Архивъ внутренней медицины |
| Subjects: | |
| Online Access: | https://www.medarhive.ru/jour/article/view/330 |
| _version_ | 1826558823070957568 |
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| author | Т. В. Кожанова Л. Ю. Ильченко М. И. Михайлов |
| author_facet | Т. В. Кожанова Л. Ю. Ильченко М. И. Михайлов |
| author_sort | Т. В. Кожанова |
| collection | DOAJ |
| description | A significant part of liver disease, once considered the result of infection by hepatitis B virus (HBV), are the result of infection HBV, and hepatitis delta virus (HDV). HDV is hepatotropic, defective RNA virus that requires obligatory HBV presence for its replication and the formation of infectious particles. About 10% of patients with chronic HBsAg-positive hepatitis infected by HDV. HDV results in coinfection (simultaneous infection of HBV and HDV) and superinfection (HDV infection with chronic hepatitis B). The natural course of the infection is characterized by rapid progression to liver cirrhosis and hepatocellular carcinoma. Diagnosis of HDV-infection is based on the detection of delta antigen, antibodies to the virus (anti-HDV IgM and IgG) and RNA HDV in serum. The effectiveness of antiviral therapy proved only on the treatment by interferon (IFN-2α and PEG-IFN-2α). The only way to protect against HDV infection is vaccination against hepatitis B. |
| first_indexed | 2024-04-10T03:56:55Z |
| format | Article |
| id | doaj.art-20c3cf0343334c4fb2120c2eeb131197 |
| institution | Directory Open Access Journal |
| issn | 2226-6704 2411-6564 |
| language | Russian |
| last_indexed | 2025-03-14T08:50:36Z |
| publishDate | 2014-10-01 |
| publisher | SINAPS LLC |
| record_format | Article |
| series | Архивъ внутренней медицины |
| spelling | doaj.art-20c3cf0343334c4fb2120c2eeb1311972025-03-02T12:48:55ZrusSINAPS LLCАрхивъ внутренней медицины2226-67042411-65642014-10-0105212810.20514/2226-6704-2014-0-5-21-28343ГЕПАТИТ ДЕЛЬТА: ЭТИОЛОГИЯ, КЛИНИКА, ДИАГНОСТИКА, ТЕРАПИЯ (ЛЕКЦИЯ ДЛЯ ПРАКТИЧЕСКИХ ВРАЧЕЙ)Т. В. Кожанова0Л. Ю. Ильченко1М. И. Михайлов2ФГБУ «Институт полиомиелита и вирусных энцефалитов им. М.П. Чумакова»ФГБУ «Институт полиомиелита и вирусных энцефалитов им. М.П. Чумакова»ФГБУ «Институт полиомиелита и вирусных энцефалитов им. М.П. Чумакова»A significant part of liver disease, once considered the result of infection by hepatitis B virus (HBV), are the result of infection HBV, and hepatitis delta virus (HDV). HDV is hepatotropic, defective RNA virus that requires obligatory HBV presence for its replication and the formation of infectious particles. About 10% of patients with chronic HBsAg-positive hepatitis infected by HDV. HDV results in coinfection (simultaneous infection of HBV and HDV) and superinfection (HDV infection with chronic hepatitis B). The natural course of the infection is characterized by rapid progression to liver cirrhosis and hepatocellular carcinoma. Diagnosis of HDV-infection is based on the detection of delta antigen, antibodies to the virus (anti-HDV IgM and IgG) and RNA HDV in serum. The effectiveness of antiviral therapy proved only on the treatment by interferon (IFN-2α and PEG-IFN-2α). The only way to protect against HDV infection is vaccination against hepatitis B.https://www.medarhive.ru/jour/article/view/330hepatitis deltacoinfectionsuperinfectionliver cirrhosishepatocellular carcinomaantiviral therapy |
| spellingShingle | Т. В. Кожанова Л. Ю. Ильченко М. И. Михайлов ГЕПАТИТ ДЕЛЬТА: ЭТИОЛОГИЯ, КЛИНИКА, ДИАГНОСТИКА, ТЕРАПИЯ (ЛЕКЦИЯ ДЛЯ ПРАКТИЧЕСКИХ ВРАЧЕЙ) Архивъ внутренней медицины hepatitis delta coinfection superinfection liver cirrhosis hepatocellular carcinoma antiviral therapy |
| title | ГЕПАТИТ ДЕЛЬТА: ЭТИОЛОГИЯ, КЛИНИКА, ДИАГНОСТИКА, ТЕРАПИЯ (ЛЕКЦИЯ ДЛЯ ПРАКТИЧЕСКИХ ВРАЧЕЙ) |
| title_full | ГЕПАТИТ ДЕЛЬТА: ЭТИОЛОГИЯ, КЛИНИКА, ДИАГНОСТИКА, ТЕРАПИЯ (ЛЕКЦИЯ ДЛЯ ПРАКТИЧЕСКИХ ВРАЧЕЙ) |
| title_fullStr | ГЕПАТИТ ДЕЛЬТА: ЭТИОЛОГИЯ, КЛИНИКА, ДИАГНОСТИКА, ТЕРАПИЯ (ЛЕКЦИЯ ДЛЯ ПРАКТИЧЕСКИХ ВРАЧЕЙ) |
| title_full_unstemmed | ГЕПАТИТ ДЕЛЬТА: ЭТИОЛОГИЯ, КЛИНИКА, ДИАГНОСТИКА, ТЕРАПИЯ (ЛЕКЦИЯ ДЛЯ ПРАКТИЧЕСКИХ ВРАЧЕЙ) |
| title_short | ГЕПАТИТ ДЕЛЬТА: ЭТИОЛОГИЯ, КЛИНИКА, ДИАГНОСТИКА, ТЕРАПИЯ (ЛЕКЦИЯ ДЛЯ ПРАКТИЧЕСКИХ ВРАЧЕЙ) |
| title_sort | гепатит дельта этиология клиника диагностика терапия лекция для практических врачей |
| topic | hepatitis delta coinfection superinfection liver cirrhosis hepatocellular carcinoma antiviral therapy |
| url | https://www.medarhive.ru/jour/article/view/330 |
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