How Does cGAS Avoid Sensing Self-DNA under Normal Physiological Conditions?

How Does cGAS Avoid Sensing Self-DNA under Normal Physiological Conditions?

cGAS is a cytosolic DNA sensor that activates innate immune responses by producing the second messenger 2′3′-cGAMP, which activates the adaptor STING. cGAS senses dsDNA in a length-dependent but sequence-independent manner, meaning it cannot discriminate self-DNA from foreign DNA. In normal physiolo...

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Bibliographic Details
Main Authors: Wangli Zheng, Nanhua Chen, François Meurens, Wanglong Zheng, Jianzhong Zhu
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
cGAS
self-DNA
mitosis
autoimmune diseases
DNases
Online Access:https://www.mdpi.com/1422-0067/24/19/14738

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